Neurology

Ton J. deGrauw, MD, PhD

Title

Director

Appointment

Professor of Pediatrics and Neurology

Email

ton.degrauw@cchmc.org

Phone

513-636-4222

Fax

513-636-3980

Bio

Ton J. deGrauw, MD, PhD, director of the Neurology Program and the Training Program in Child Neurology at Children's Hospital Medical Center of Cincinnati, is creating a department that offers a variety of high-quality treatments for children with different neurological disorders. For that purpose, Dr. deGrauw has established different specialty programs, and he will continue to begin additional programs if opportunities occur.

Dr. deGrauw's personal interest is in the area of neurodevelopmental deficits as well as neurodegenerative and neurometabolic disorders. His metabolic interest is specifically focused on disorders of energy metabolism.

Dr. deGrauw is also interested in the neurological aspects of language development.

Dr. deGrauw encourages communication with other people (colleagues, parents) to investigate the possibility of establishing new neurology programs at Cincinnati Children's Hospital Medical Center.

Credentials

MD: Katholieke Universiteit (K.U.), Nijmegen, Netherlands, 1979.

Residency: Pediatrics, St. Radboud Hospital , Netherlands, 1979-82.

Fellowship: Neurology, University Hospital, Cincinnati, Ohio, 1982-83; Pediatrics and Neurology, Children's Hospital Medical Center, Cincinnati, Ohio, 1983-85; Research Associate in Neonatal Neurology, Children's Hospital Medical Center, Cincinnati, Ohio, 1985-86.

Certification: Pediatrics, 1985; Neurology, 1995.

Awards and Honors

Best Doctors in America, 2008
Awarded "2005 Best Doctors"
American Academy Cerebral Palsy and Developmental Medicine, Continuing Education.
Co-organizer of the 6th International Guanidino compound meeting, held at Cincinnati Children's Hospital Medical Center.

Research Grants and Contracts

Local Principal Investigator, Childhood Epilepsy: Factors Affecting Adaptation.; Dr. Joan Austin, Indiana University, principal investigator; sponsor: NIH; duration: five years; effort: 12 percent.

Co-investigator, Pediatric Study Centers (PSCs) for a MRI Study of Normal Development.; Dr. William Ball, principal investigator; National Institutes of Health (NIH)-NINDS-98-13; duration: five years; effort: five percent.

Local Principal Investigator, Childhood Epilepsy: Factors Affecting Adaptation.; Dr. Joan Austin, Indiana University, principal investigator; sponsor: NIH; duration: five years; effort: 12 percent.

Publications, Most Recent

Tang PH, Miles MV, deGrauw A, Hershey A, and Pesce, A: HPLC analysis of reduced and oxidized coenzyme Q10 in human plasma. Clinical Chemistry 47:2, 256-265, 2001.

Cecil KM, Salomons GS, Ball WS, Wong B, Chuck G, Verhoeven NM, Jakobs C and deGrauw TJ. Irreversible brain creatine deficiency with elevated serum and urine creatine: A creatine transporter defect. Ann Neurol 49:401-404, 2001.

Salomons G, VanDorren SJM, Verhoeven NM, Cecil K, Ball WS, deGrauw TJ and Jakobs C: X-linked creatine-transporter gene (SLC6A8) defect: A new creatine-deficiency syndrome. Am J Hum Genet 68:1497-1500, 2001.

Tang PH, Miles MV, Steele P, deGrauw TJ, Chuck G, Schroer L and Pesce A: Anticoagulant effects on plasma coenzyme Q10 estimated by HPLC with coulometric detection. Clinica Chimica Acta 318: 127-131, 2002.

DeGrauw TJ, Salomons GS, Cecil KM, Ball WS, Jakobs C: The clinical syndrome of creatine transporter deficiency. Molecular and Cellular Biochemistry. In press.

Professional Organization Memberships

American Academy Cerebral Palsy and Developmental Medicine, Continuing Education, 1998 to present
American Medical Association
American Academy of Neurology
Child Neurology Society (USA)
Dutch Pediatric Neurology Association
American Association for the Advancement of Science
United Leukodystrophy Foundation
American Academy for Cerebral Palsy and Developmental Medicine, Professors of Child Neurology

Abstracts

Cecil KM, deGrauw A, Ball WS and Hug G: Elevated brain lactate in glycogen storage disease type 1 as demonstrated with proton MR spectroscopy. 85th Scientific Assembly and Annual Meeting of the Radiological Society of North America. Radiology 213P, 357, 1999.

Cecil KM, Ball WS, deGrauw TD: Evaluating mitochondrial dysfunction with proton MR spectroscopy methods: Results of a lactate challenge. 38th Annual Meeting of the American Society of Neuroradiology, Atlanta, GA, April, 2000.

Miles MV, Tang P, deGrauw TJ, Steele P, Pesce A, Bean J, Hershey AD and Jones J: Age-related differences of Coenzyme Q10 in the plasma of healthy individuals. Mitochondrial Cytopathies 2000, United Mitochondrial Disorders Foundation, Cleveland, June, 2000.

Tang P, Miles MV, deGrauw TJ, Steele P, Pesce A, Bean J,Hershey AD and Jones J: Reliable measurement of reduced and oxidized Coenzyme Q10 in human plasma. Mitochondrial Cytopathies 2000, United Mitochondrial Disorders Foundation, Cleveland, June, 2000.

Tang PH, Miles MV, deGrauw T, Steele PE, Hershey A, Schroer L, Chuck G, Jones J, Pesce A: Simple and rapid HPLC method with coulometric detection of coenzyme Q10 in human plasma and CSF. Proceedings of the 219th ACS National Meeting.

Cecil KM, deGrauw AJ, and Ball WA: A new X-linked creatine deficiency syndrome indicated by proton MRS: A creatine transporter defect. Annual Meeting of the American Society of Neuroradiology, Boston, MA, April 23, 2001, 17.

Tang PH, Miles MV, Steele P, deGrauw A, Pesce A: Effect of anticoagulant on stability of coenzyme Q10: heparin vs. EDTA. Clinical Chemistry, Vol 47, NO 6, supplement. AACC/CSCC Annual Meeting and Clinical Laboratory Exposition, Chicago, IL, July 29, 2001.

Salomons GS, vanDooren SJ, Bunea D, Verhoeven NM, Cecil KM, Ball WS, deGrauw TJ and Jakobs C: X-linked creatine transporter defect: The first two families. Sixth International Conference on Guanidino Compounds in Biology and Medicine, Cincinnati, OH, September 1, 2001, 42.

DeGrauw TJ, Cecil KM, Salomons GS, Silvy JM, van Dooren SJ, Verhoeven NM, Ball WS and Jakobs C: Sixth International Conference on Guanidino Compounds in Biology and Medicine, Cincinnati, OH, September 1, 2001, 42.

Salomons GS, van Dorren SJ, Verhoeven NM, Cecil KM, Ball WS, deGrauw TJ, and Jakobs C: X-linked creatine transporter defect: The second family. Journal of Inherited Metabolic Disease, Vol 24, supplement 1, SSIEM 39th Annual Symposium, September, 2001.

Miles MV, Tang P, Miles L, Steele P, Horn P, Bean J and deGrauw T: Bioequivalence of three coenzyme Q10 formulations in healthy adults. J Clin Pharmacol 41:1014-1033, ACCP 30th Annual Meeting, Vienna, VA, September 23, 2001.

Cecil KM, Ball WS and deGrauw TJ: Proton MR spectroscopy reveals absent brain creatine: A defect in the creatine transporter. Radiological Society of North America, Chicago, IL, November 28, 2001, 1068.

Miles MV, Tang PH, Miles L, Steele P, Bean J, and deGrauw T: Antiepileptic drug treatment lowers coenzyme Q10 levels in children. 55th annual Meeting of American Epilepsy Society, Philadelphia, PA, November 30, 2001

Tang PH, Miles MV, deGrauw T, and Steele PE: Measurement of the ratio between the reduced forms and total of coenzyme Q9 and coenzyme Q10 in mice tissues. Ohio River Valley 2002 Conference and Exhibition, Indianapolis, IN, March 13, 2002.

Tang PH, Miles MV, Steele P and deGrauw T: Ratios of reduced forms in total coenzyme Q9 and coenzyme Q10 in mice tissue. AACC Meeting, July, 2002. Clinical Chemistry, vol 48, No 6, July, 2002.