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Xiang Lab

Contact Dr. Xiang
Jing Xiang, MD, PhD
MEG Center
Department of Neurology
Cincinnati Children's Hospital Medical Center
MLC 2015
3333 Burnet Avenue, OH 45229
Email jing.xiang@cchmc.org
Phone 513-636-6303
Fax 513-636-1888
Jing Xiang

Our research program focuses on magnetoencephalography (MEG), particularly, high-frequency neuromagnetic signals originating from the human brain. MEG is a new tool for noninvasively measuring very weak magnetic signals. Newly developed high-sampling-rate MEG recording techniques allow the clinician/researcher to address questions that exceed the capabilities of traditional approaches.

Our preliminary data indicate that high-frequency neuromagnetic signals are a new window for functional analysis of the brain activity. However, high-frequency neuromagnetic signals in the child's brain have not been previously studied. Brain background activities evolve in childhood. High-frequency neuromagnetic signals may provide unique information about brain maturation and development.

Thus, our study focuses on high-frequency signals in the pediatric and adolescent brain with a specific clinical focus on the surgical treatment of medication resistant epilepsy. We also aim to develop new techniques to non-invasively localize seizure onset regions and ultimately avoid lengthy, costly, and risky invasive intracranial electroencephalographic (EEG) recordings to find the abnormal epileptic regions requiring surgical removal.

Areas of research include:

  • Volumetric localization and visualization of high-frequency neuromagnetic signals
  • Quantitative investigation of neuromagnetic activation in normal children and children with epilepsy
  • Localizing sensorimotor, auditory, visual and language cortices in children with MEG.
Research Images

Publications

  • Xiao Z, Xiang J, Holowka S, et al (2006). Volumetric localization of epileptic activities in tuberous sclerosis using synthetic aperture magnetometry. Pediatric Radiology, 36(1):16-21.
  • Oishi M, Otsubo H, Iida K, Suyama Y, Ochi A, Weiss SK, Xiang J, Gaetz W, Cheyne D, Chuang SH, Rutka JT, Snead OC (2006). Preoperative simulation of intracerebral epileptiform discharges: synthetic aperture magnetometry virtual sensor analysis of interictal magnetoencephalography data. J Neurosurg. Jul;105(1 Suppl):41-9.
  • Xiang J, Sam J.Daniel, Ryouhei Ishii, et al (2005) Auditory Detection of Motion Velocity in Humans: a magnetoencephalographic Study. Brain Topography 17(3):139-149.
  • Xiang J, Holowka S, Qiao H, et al (2004) Automatic Localization of Epileptic Zones Using Magnetoencephalography. Neurology and Clinical Neurophysiology 98:1-5.
  • Xiang J, Holowka S, Qiao Q, et al (2004) Volumetric Estimation of Functional Brain Regions in Small Children using Spatially Filtered Magnetoencephalography: Differentiating Thumb from Middle Finger. Neurology and Clinical Neurophysiology 110:1-5.
  • Xiang J, Holowka S, Ishii R, et al (2004) Dynamic Neuromagnetic Responses to Auditory Motion: A Novel Index for Evaluation of Attention. Neurology and Clinical Neurophysiology 106:1-4.
  • Xiang J, Holowka S, Chuang S (2004) Spatiotemporal Analysis of Neuromagnetic Activation Associated with Mirror Reading. Neurology and Clinical Neurophysiology 90:1-4.
  • Holowka SA, Otsubo H, Iida K, Pang E, Sharma R, Hunjan A, Xiang J, Snead III OC, Chuang NA, Chuang SH, Rutka JT. (2004) Three dimensionally reconstructed magnetic source imaging and neuronavigation in pediatric epilepsy. Neurosurgery, 55(5) 1244-1248