Ophthalmology

Richard A. Lang, PhD

Title

Emma and Irving Goldman Scholar

Appointment

Professor

Email

richard.lang@cchmc.org

Credentials

BSc: 1984 (with honors), University of Melbourne, Australia. Co-major in genentics and biochemistry.

PhD: 1988, University of Melbourne, Australia, at the Ludwig Institute for Cancer Research under Drs. AR Dunn and TJ Gonda.

Postdoctoral Fellow: 1989-92, The G.W. Hooper Research Foundation, University of California, San Francisco under Dr. JM Bishop. Studied the role of the macrophage in developmentally programmed tissue remodeling.

Position History

1993-96
Assistant Professor, Skirball Institute for Biomolecular Medicine, Cell Biology (primary appointment) and Pathology Departments, Skirball Institute for Biomolecular Medicine, New York University School of Medicine.

1997-2001
Associate Professor, Skirball Institute for Biomolecular Medicine, Cell Biology (primary appointment) and Pathology Departments, Skirball Institute for Biomolecular Medicine, New York University School of Medicine.

2001-present
Professor, Emma and Irving Goldman Scholar, Divisions of Developmental Biology and Ophthalmology, Cincinnati Children's Research Foundation.

Awards and Honors

1984 The Roy and Iris Simmons Prize for academic achievement
1985 Commonwealth Postgraduate Research Award
1989 C. J. Martin National Health and Medical Research Council Postdoctoral Fellowship
1991 Leukemia Society of America Special (Senior) Postdoctoral Fellowship
1993 American Cancer Society Institutional Research Grant
1993 Elsa U. Pardee Foundation research grant
1994 Searle Scholar
1999 NYU School of Medicine multiple research grant incentive award
2000 NYU School of Medicine multiple research grant incentive award
2001 NYU School of Medicine multiple research grant incentive award

Research

Visit the Lang Lab Site.

Research Grants and Contracts

Current

RO1 EY14102: "Molecular regulation of lacrimal gland branching" 5 years until 8-3-06.

RO3 EY14826: "A cell-based therapy for cataracts" 3 years until 10-30-06.

RO1 EY15766: "Wnts in programmed vessel regression". 5 years until 5-30-09.

RO1 EY16241: "Cadherin function in lens morphogenesis". Percentile 1.1, awaiting award.

Past

American Cancer Society Institutional Grant. "An in vitro assay for macrophage-dependent tissue remodeling".

Elsa U. Pardee Foundation. "The role of the macrophage in anti-tumor immunity: An in vivo system".

Searle Scholars Program. "The role of the macrophage in anti-tumor immunity: An in vivo system".

RO1 EY12370: "Molecular basis of vertebrate lens induction" Co-PI with Ali Hemmati-Brivanlou of Rockefeller University. Held for 5 years from 12-1-98 to11-30-03.

RO1 EY10559: "Developing vision: The mechanism of tissue remodeling" Held for 10 years from 6-1-94 to 5-31-05.

RO1 EY11234: "Developing vision: Growth factors in lens morphogenesis" Held for 9 years from 1-26-96 to12-31-04.

Predoctoral Fellowships to Lab Members

NIH Minority Supplement awarded to Patricia Dimanlig. "The mechanism of lens induction and development" $35,000/yr for 2.5 year period.

Postdoctoral Fellowships to Lab Members
KO8 awarded to Irene Nunes. "The function of GRIFIN in lens development"

Japanese Government Fellowship Awarded to Masataka Ito from the Japanese Medical Defense College. "The mechanism of programmed capillary regression"

NIH NRSA Awarded to Curtis Altmann. "Vertebrate lens induction"

Publications, Most Recent

Richard Lang's publications as listed by PubMed

J Treisman and RA Lang (2002). Development and Evolution of the Eye; A meeting report from Fondation des Treilles.Mechanisms of Development, 112, 3-8.

M Kato, MS Patel, R Levasseur, *I Lobov, B Chang, DA Glass, II, C Hartmann, L Li, TH Huang, C Brayton, RA Lang, G Karsenty, L Chan. (2002). Abnormal osteoblast proliferation, low bone mass and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor.J. Cell Biology, 157, 303-314. *Lang lab member equal first author.

S Faber, M Robinson, H Makarenkova, and RA Lang (2002). BMP signaling is required for primary lens fiber cell differentiation.Development, 129, 3727-3737.

IB Lobov, P Brooks and RA Lang (2002). Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo.PNAS, 99, 10943-11546.

S Jung, D Unutmaz, P Wong, K De los Santos, T Sparwasser, S Wu, S Vuthoori, K Ko, EG Pamer, DR Littman, RA Lang. (2002). Requirement of CD11c+ Dendritic Cells for In Vivo CD8 T Cell Cross Priming.Immunity, 17, 211.

RA Lang and J McAvoy. Growth factors in lens development (2004). Chapter for "Development of the ocular lens" Editors Michael Robinson and Frank Lovicu.

C Dean, M Ito, HP Makarenkova, and RA Lang. (2004). Bmp7 modulates mesenchymal function and promotes branching during morphogenesis of the lacrimal gland.Development, 131, 4155-4165.

RA Lang. Pathways regulating lens induction in the mouse. (2004). Int. J. Dev. Biol., 48, 783-91.

N Gotoh, M Ito, I Lax, S Yamamoto, I Yoshino, M Shibuya, N Song, Y Wang, J Schlessinger and RA Lang (2004). Frs2? plays a role in lens and retina inductive signaling.PNAS, 101, 17144-17149.

JS Duffield, Stuart J Forbes, CM Costandinou, S Clay, M Partolina, S Vuthoori, S Wu, RA Lang, and John P Iredale (2005). Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.J. Clinical Investigation, 115, 56-65.

JF Cailhier, M Partolina, S Vuthoori, S Wu, K Ko, S Watson, J Savill, J Hughes and RA Lang (2005). Conditional macrophage ablation demonstrates the resident macrophages initiate acute peritoneal inflammation.J. Immunol. 174, 2336-2342.

Donald A Glass, II, P Bialek, JD Ahn, M Starbuck, MS Patel, H Clevers, MM Taketo, AP McMahon, RA Lang, and G Karsenty (2005). Canonical Wnt Signaling in Osteoblasts is an Essential Regulator of Osteoclast Differentiation.Dev. Cell, In press.

IB Lobov, S Rao, TJ Carroll, J Vallance, M Ito, JK Ondr, S Kurup, D Glass, M Patel, W Shu, EE Morrisey, A McMahon, G Karsenty and RA Lang. Wnt7b mediates macrophage-induced programmed cell death during vascular patterning.Nature, In press.

AN Smith, LA Miller, N Song, MM Taketo and RA Lang. The duality of ß-catenin function: A requirement for lens morphogenesis and suppression of lens cell fate.Developmental Biology, In press.

Teaching

Join members of the Visual Systems Research Group for the The Great Lakes and Abrahamson Pediatric Eye Institute Vision Research Conference, November 11-12, 2005. Learn more about this conference here.

Invited Seminars Since 1992

1992 - 1994
Memorial Sloan Kettering Cancer Center, New York
Fred Hutchinson Cancer Research Center, Seattle.
Columbia University College of Physicians and Surgeons, New York, Dept. of Biochemistry
New York University Medical Center, Department of Cell Biology
University Washington, Seattle, Department of Immunology
Rockefeller University, New York
DNAX, Palo Alto, California
Searle Scholars meeting, Chicago (1993 and 1994)
UMDNJ, Dept. Biochemistry and Genetics, New Jersey
Alton Jones Cell Science Center Apoptosis Conference, Lake Placid, New York

1995-1998
Rockefeller University, New York
Searle Scholars meeting, Chicago
Gordon Research Conference on Cell Death (1995 and 1997)
SUNY Brooklyn
New York area Cell Death Society, Rockefeller University
Picower Institute at North Shore University Hospital
Cold Spring Harbour Conference on Programmed Cell Death
Fred Hutchinson Cancer Research Center, Seattle
University of Washington, Seattle, Dept Immunology
UMDNJ, Dept. Biochemistry and Genetics, New Jersey

1999
Belgian Society for Cell Biology, Gent
Phagocytes Gordon Conference
Genentech, Inc.
Glaucoma Foundation "Think Tank"
Baylor College of Medicine
Albert Einstein College of Medicine

2000
EMBO conference on the homeodomain, Ascona, Italy
Rheumatology Department, Tisch Hospital, NYU
Woods Hole course lecturer: "Fundamental Issues in Vision Research: Molecular and Cell Biological Approches" lecture on Pax6
ICER (International Congress of Eye Research) conference, Santa Fe
Banbury Center meeting on cell death and phagocytic recognition
Developmental Biology Division, Cincinnati Childrens' Hospital

2001
New York University Biology Department
Conference on Eye Development and Evolution, Provence, France

2002
University of Texas, MD Anderson
University of Cincinnati, 7th Annual Ophthalmology Research Symposium
University of Pennsylvania
Visual Systems Gordon Conference
Woods Hole course lecturer: "Fundamental Issues in Vision Research: Molecular and Cell Biological Approaches" lecture on Pax6
University of Alabama at Birmingham, Department of Cell Biology
University of Dayton

2003
Pasteur Institute
University of Edinburgh
Great Lakes Vision Research Conference, Chair, Lens Regeneration session

2004
North American Vascular Biology Organization
Keystone Meeting on Cell Death in Development
Genentech, Inc.
Association for Research in Vision and Ophthalmology. Minisymposium on signaling pathways in lens development.
Genetic control of eye development and evolutionary implications, Madrid
Max Planck Institute for Molecular Genetics, Berlin
Chair and speaker, Determination session, Gordon Research Conference on Visual Systems Development
Riken Institute Vascular Biology Symposium, Japan
University of Tokyo, Institute of Medical Science.
International Congress for Eye Research, Sydney, Australia
Walter and Eliza Hall Institute, Melbourne, Australia

2005
University of Cincinnati, 8th Annual Ophthalmology Research Symposium
Miami University, Research Seminar Series
First Annual Conference of the ARVO/Pfizer Ophthalmics Research Institute on Angiogenesis, Neovascularization and Vasoproliferation.
Organizer, Combined Children's Hospital Research Foundation and Great Lakes Vision
Research Conferences, Cincinnati.

2006
Cornell University, Department of Cell and Developmental Biology