Overview
The Division of Pathology & Laboratory Medicine at Cincinnati Children's Hospital Medical Center provides full anatomic pathology and clinical lab diagnostic service to patients at Cincinnati Children's Hospital Medical Center as well as regional and national diagnostic consultation service.
The anatomic pathology clinical service utilizes traditional tools of anatomic pathology including light microscopy, histochemistry, immunohistochemistry and electron microscopy (EM) as well as providing molecular technology including in situ hybridization and PCR analysis.
The clinical lab utilizes state-of-the-art facilities, technology and technical expertise to provide a diagnostic testing service including microbiology, virology, serology, chemistry, special chemistry and hematology as well as a full service blood transfusion program in cooperation with the Hoxworth Regional Blood Center.
In addition to the base lab, which performs just under 2,000,000 diagnostic tests, the recently established clinical lab operation at the Bethesda Oak facility provides core support for the lab services at the Cincinnati Center for Clinical Research. This lab was established to perform lab studies in support of human clinical trials in accordance with FDA and GLP quality standards. This lab operation has continued to grow and has become the reference testing lab for nationally based clinical research organizations such as Community Medicine and PediaMed.
The division has an accredited fellowship training program in pediatric pathology as well as being an integral component of the University of Cincinnati Pathology Department residency training program by providing pediatric pathology learning experience for the pathology residents who rotate through Cincinnati Children's.
The Division has an active research program both at the clinical and basic science level. Ongoing clinical collaborative studies involve most clinical subdivisions at Cincinnati Children's including a wide range of clinical disorders such as eosinophilic GI disorders, motility disorders, metabolic liver diseases, inflammatory bowel disease, interstitial lung disease, and muscle disorders. The basic research in the molecular path lab focuses on a better understanding of the molecular and biologic mechanisms that contribute to the pathogenesis of developmental anomalies in childhood diseases through a morphologic understanding of the processes that regulate and promote normal development during embryogenesis.
The division also provides core morphology lab support for numerous NIH funded projects throughout Cincinnati Children's as well as investigators at UC. During the past year the core morphology lab accessioned more than 1,000 new projects, generated more than 22,000 histologic slides, 1,700 immunohistochemical stains and 400 hours of EM support for a wide-range of basic research projects.
The mass spectroscopy center under the direction of Dr. Ken Setchell joined the division this past year, adding sophisticated mass spectral analysis to the testing platform for the division's diagnostic service as we expand the research program and research support for Cincinnati Children's.
