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Pathology

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Kathryn A. Wikenheiser-Brokamp, MD, PhD.

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Kathryn A. Wikenheiser-Brokamp, MD, PhD

Title

Assistant Professor, in the Departments of Neonatology and Pulmonary Biology and Pathology

Appointment

Assistant Professor, Pathology, University of Cincinnati College of Medicine

Email

kathryn.wikenheiser-brokamp@cchmc.org

Phone

513-803-0239

Fax

513-636-7868

Credentials

BS: Mathematics/Natural Science, Secondary Education Minor, University of Mary, Bismarck, ND, 1988.

PhD: Developmental Biology, Developmental Biology and Medical Science Scholars Programs, University of Cincinnati, Cincinnati, OH, 1994.

MD: Medical Science Scholars Program, University of Cincinnati, Cincinnati, OH, 1996.

Residency: Anatomic Pathology, Department of Pathology and Immunology, Washington University-Barnes/Jewish Hospital, St. Louis, MO, 1996-2002.

Clinical Training/Postdoctoral Research: Department of Pathology and Immunology, Washington University, St. Louis, MO, 1999-2002.

Licensure: State of Ohio, 2003.

Certification: Anatomic Pathology, The American Board of Pathology, 1999.

Position History

Biology Teacher, Century High School, Bismarck, ND, 1988.

Research Associate, Divisions of Oncology and Pulmonary & Critical Care Medicine, Washington University, St. Louis, MO, 2002-2003.

Assistant Professor, Department of Pathology & Laboratory Medicine, University of Cincinnati, Cincinnati, OH, 2003-2007.

Assistant Professor, Pathology & Laboratory Medicine and Neonatology, Perinatal & Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2007-present.

Awards and Honors

  • Summa cum laude, University of Mary, Bismarck, ND, 1988.
  • Mathematics/Natural Science Outstanding Student Award, University of Mary, Bismarck, ND, 1988.
  • Education Outstanding Student Award, University of Mary, Bismarck, ND, 1988.
  • Krucker Scholarship, Medical Science Scholars Program, University of Cincinnati, Cincinnati, OH, 1991.
  • Dean's Distinguished Dissertation Fellowship, University of Cincinnati, Cincinnati, OH, 1994.
  • Alpha Omega Alpha, Beta Chapter of Ohio, University of Cincinnati, Cincinnati, OH, 1995.
  • David B. Confer Memorial Award, Department of Pathology, University of Cincinnati, Cincinnati, OH, 1996.
  • Samuel A. Trufant Award, Department of Neurology, University of Cincinnati, Cincinnati, OH, 1996.
  • Janet M. Glasgow Memorial Award, American Medical Women's Association, Inc., 1996.
  • Harold Schafer Alumni Leadership Award, University of Mary, Bismarck, ND, 2002.

Research

Pediatric and adult lung diseases, including cancer, are characterized by aberrant epithelial cell growth and differentiation. Our research is focused toward determining the molecular mechanisms underlying Rb/p16, p53, and Dicer1 pathway function in lung development and the pathogenesis of lung disease. The ultimate goal is to identify potential diagnostic, prognostic and therapeutic targets for common pulmonary disorders that account for significant human morbidity and mortality.

Research Grants and Contracts

NIH/NHLBI RO1 HL079193 - Role of Rb Family in Lung Epithelial Response to Injury, 04/01/05-01/31/10, PI-K.A. Wikenheiser-Brokamp.

Society for Pediatric Pathology - Role of Dicer1 in the Pathogenesis of Pleuropulmonary Blastoma, 07/01/09-06/30/10, PI-K.A. Wikenheiser-Brokamp.

American Cancer Society RSG MGO-108441 - Role of Retinoblastoma Protein Family in Lung Carcinogenesis, 01/01/05-02/28/09 (balance returned in favor of RO1), PI-K.A. Wikenheiser-Brokamp.

American Cancer Society, Ohio Division, Inc. Retinoblastoma Gene Product (Rb) in Lung Carcinogenesis, 04/01/04-03/31/05, PI-K.A. Wikenheiser-Brokamp.

Role of Rb Family in Lung Epithelial Response to Injury, NIH/NHLBI, RO1 HL079193, Principal Investigator, 4/2005 - 02/2009.

Role of Retinoblastoma Protein Family in Lung Carcinogenesis, American Cancer Society, RSG MGO-108441, Principal Investigator, 01/2005 - 12/2009 (balance returned 4/2005 in favor of RO1).

Retinoblastoma Gene Product (Rb) in Lung Carcinogenesis, American Cancer Society, Ohio Division, Inc., Principal Investigator, 04/2004 - 03/2005.

Publications, Most Recent

Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J. and McCormack, F.X.: Utility of FDG-PET in Lymphangioleiomyomatosis and Tuberous Sclerosis Complex. Chest, 2009 Apr 6. [Epub ahead of print].

Wise-Draper, T.M., Mintz-Cole, R.A., Morris, T.A., Simpson, D.S., Wikenheiser-Brokamp, K.A., Currier, M.A., Cripe, T.P., Grosveld, G.C., and Wells, S.I.: Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.
Cancer Res., 69(5):1792-1799, 2009.

Hoskins, E.E., Morris, T.A., Higginbotham, J.M., Spardy, N., Cha, E., Kelly, P., Williams, D.A., Wikenheiser-Brokamp, K.A., Duensing, S. and Wells, S.I.: Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. Oncogene, 28(5):674-685, 2009.

Wise-Draper, T.M., Morreale, R.J., Morris, T.A., Mintz-Cole, R.A., Hoskins, E.E., Balsitis, S.J., Husseinzadeh, N., Witte, D.P., Wikenheiser-Brokamp, K.A., Lambert, P.F., and Wells, S.I.: DEK proto-oncogene expression interferes with the normal epithelial differentiation program.Am. J. Pathol., 174(1):71-81, 2009.

Mason-Richie, N.A., Mistry, M.J., Gettler, C.A. Elayyadi, A., and Wikenheiser-Brokamp, K.A.: Retinoblastoma function is essential for establishing lung epithelial quiescence after injury.
Cancer Res. 68 (11):4068-4076, 2008.

Duran, A., Linares, J.F., Galvez, A.S., Wikenheiser, K., Flores, J.M., Diaz-Meco, M.T. and Moscat, A.: The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis.Cancer Cell 13 (4):343-354, 2008.

Castro, D.E., Wikenheiser-Brokamp, K.A., and Sinha, P.: A 56-year-old Honduran man with fever, weight loss and pleuritic chest pain. Infect. Dis. Clin. Prac., 16(1):36-40, 2008.

Wikenheiser-Brokamp, K.A.: 50 Year Ago in The Journal of Pediatrics; Bronchopulmonary sequestration in infancy and childhood.J. Pediatr. 153(5):658, 2008.

Ciampi, R. Giordano, T.J., Wikenheiser-Brokamp, K.A., Zhu, Z., Koenig, R.J. and Nikiforov, Y.E.: Hook3-Ret: A novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocr. Relat.Cancer 14:445-452, 2007.

Crimmins, J.T., Willmott, W.C., Wikenheiser-Brokamp, K.A., Shipley, R.T. and Reed, M.F.: Middle-aged West African man referred from tuberculosis clinic with abnormal chest radiograph. Infect. Dis.Clin. Prac., 15(4):257-260, 2007.

Mayhew, C.N., Carter, S.L., Fox, S. R., Sexton, C.R., Reed, C.A., Srinivasan, S.V., Liu, X., Wikenheiser-Brokamp, K.A., Boivin, G.P. Lee, J., Aronow, B.J., Thorgeirsson, S.S. and Knudsen, E.S.: RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.Gastroenterology, 133:976–984, 2007.

Wikenheiser-Brokamp, K.A.: Retinoblastoma family proteins: insights gained through genetic manipulation of mice.
Cell. Mol. Life Sci. 63:767-780, 2006.

Wikenheiser-Brokamp, K.A.: Retinoblastoma gene and lung cancer. Curr. Mol. Med. 6(7):783-793, 2006.

Wikenheiser-Brokamp, K.A.: Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development; 131:4299-4310, 2004.

Wikenheiser-Brokamp, K.A.: Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Invited Review. Cell. Mol. Life Sci.; 63:767-780, 2006.

Wikenheiser-Brokamp, K.A.: Retinoblastoma gene and lung cancer. Invited Review. Curr. Mol. Med.; 6(7): 783-793, 2006.

Professional Organization Memberships

Special Interests

Pulmonary pathology

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: