Cincinnati Children's Hospital Medical Center Logo

University of Cincinnati Department of Pediatrics

Loading...
Alan Jobe.

<Click for High-Res Image>

Alan H. Jobe, MD, PhD

Title

Director, Perinatal Biology

Appointment

Professor of Pediatrics, University of Cincinnati College of Medicine

Email

alan.jobe@cchmc.org

Phone

513-636-8563

Fax

513-636-8691

Credentials

MD: University of California, San Diego, 1973.

PhD: Cell Biology, University of California, San Diego, CA, 1973.

Residency: Pediatrics, University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: Neonatology, University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine

Position History

Professor of Pediatrics, University of Cincinnati, 1997 - Present

Joseph W. St. Geme, Jr. Professor of Pediatrics, UCLA School of Medicine, 1995 - 1997

Director of Perinatal Research Laboratories and, Walter P. Martin Research Center, 1991 - 1997

Professor of Pediatrics, Harbor-UCLA Medical Center, 1983 - 1997

Director, Neonatal Intensive Care Unit, Director, Pulmonary Research Laboratory, Harbor-UCLA Medical Center, July 1980 - 1986

Associate Professor of Pediatrics, Harbor-UCLA Medical Center, July 1980 - June 1983

Assistant Professor of Pediatrics, Harbor-UCLA Medical Center, July 1977 - June 1980

Awards and Honors

  • William Silverman Lectureship, American Academy of Pediatrics, 2009
  • Best Doctors in America, 2008
  • Adjunct Clinical Professor - University of Western Australia, 2007
  • Elected to Institute of Medicine USA, 2007
  • Awarded "2005 Best Doctors"
  • George Simbruner Lecturin Award at New Frontiers in Neonatology, 2005
  • Awarded "2004 Best Doctors"
  • Alvo Ylppö Medal for Pediatric Research, Finnish Pediatric Societies, 2002
  • Awarded Arvo Ylppo Medal – Pediatric Academic Societies of Finland, 2002
  • Mead Johnson Excellence in Teaching Awards – CHMC, 1999, 2000
  • E. Mead Johnson Research Award, American Academy of Pediatrics, 1986
  • Voted Best Teacher by Pediatric Housestaff, Harbor-UCLA Medical Center, 1986
  • Ross Award in Research, Western Society for Pediatric Research, 1984
  • Richard E. Weitzman Award in Research, Harbor-UCLA Faculty Society, 1982
  • Voted Best Teacher by Pediatric Housestaff, Harbor-UCLA Medical Center, 1980
  • Phi Beta Kappa, Stanford, 1967
  • Honors in Biology, Stanford, 1967

Research

  • Lung maturation and lung injury in the fetus and newborn
  • The use of antenatal corticosteroids
  • Lung injury with ventilation of the preterm

Research Grants and Contracts

  • NIH-NICHD R01 - 02/03/09-02/02/2014, Co-Investigator, Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis.
  • NIH-NICHD R01 - 05/01/06-03/31/2011, Principal Investigator, Neonatal Resuscitation and Preterm Lung Injury.

Publications, Most Recent

Alan Jobe's publications as listed by PubMed

Original Articles

Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.AJOG 2009;200(1):96.e1-6.

Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation.Pediatr Res 2009;65(1):67-71.

Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis.Am J Physiol Lung Cell Mol Physiol 2008;296:L384-93.

Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs.Resuscitation 2008;80:133-7.

Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung.The Anatomical Record 2008;291:1271-7.

Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs.Pediatr Res 2008;64:517.

Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung.Pediatr Res 2008;63:388-93.

Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs.Neonatology 2008;94:79-86.

Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep.AJOG 2007;197:523.

Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep.Am J Ob Gyn 2008;198:122e18. 

Cheah F-C, Jobe AH, Moss TJ, Newnham JP, Kallapur SG. Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model.Pediatr Res 2008;63:274-9.

Kallapur SG, Jobe AH, Ball MK, Nitsos I, Moss TJM, Hillman NH, Newnham JP, Kramer BW. Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis.J Immunol 2007;179:8491-9. 

Polglase GR, Nitsos I, Jobe AH, Newnham JP, Moss TJM. Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs.Pediatr Res 2007;62:32-6. 

Hillman N, Moss TJM, Kallapur SG, Bachurski C, Pillow J, Polglase G, Nitsos I, Kramer B, Jobe AH. Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep.AJRCCM 2007;176:575-81. 

Kramer BW, Joshi SN, Moss TJM, Newnham JP, Sindelar R, Jobe AH, Kallapur SG. Endotoxin-induced maturation of monocytes in preterm fetal sheep lung.Am J Physiol Lung Cell Mol Physiol 2007;293:L345-53. 

Pillow JJ, Hillman N, Moss TJM, Polglase G, Bold G, Beaumont C, Ikegami M, Jobe AH. Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs.Am J Respir Cit Care Med 2007;176:63-9. 

Clyman RI, Saha S, Jobe A, Oh W. Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice.J Pediatr 2007;150:46-60.

Book Chapters, Review Articles, Editorials

Jobe AH. Postnatal Corticosteroids for Bronchopulmonary Dysplasia. In: Current Controversies in Perinatology V, eds. Uhing MR, Kleigman R.; W.B. Saunders Co., 2009, 177-188.

Abman S, Jobe A, Chernick V, Blaisdell C, et al. Strategic plan for pediatric respiratory diseases research: an HNLBI working group report. Pediatr Pulmonol 2009;44:2-13.

Kramer BW, Kallapur S, Newnham J, Jobe AH. Prenatal inflammation and lung development. Semin Fetal Neonatal Med. 14:2-7, 2009.  Epub 10/08/08

Jobe AH. Postnatal corticosteroids for bonchopulmonary dysplasia. Clin Perinatol 2009;36:177-88.

NHLBI Working Group Report - Strategic Plan for Pediatric Respiratory Diseases Research. Abman S, Jobe AH, Chernick V, Blaisdell (editors), Proc. Am. Thorac. Soc., 6:1-10, 2009.

Jobe AH. Commentary on - Respiratory Disorders:  Randomized trial of a single repeat dose of prenatal betamethasone treatment in imminent preterm birth. In: Yearbook of Neonatal and Perinatal Medicine, eds. A. Fanaroff, R. Ehrenkranz, D. Stevenson, 135-137, 2008

Newnham JP, Jobe AH. Should we be prescribing repeated courses of antenatal corticosteroids? Seminars in Fetal & Neonatal Medicine. Dec. 2008.

Jobe A. Fetal lung development and surfactant.  In: Maternal Fetal Medicine - Principals and Practice,  6th Ed., R. Creasy and R. Resnik, ed.  W.B. Saunders Co., 2008, 193-205

Jobe AH, Hillman N, Polglase G, Kramer BW, Kallapur S, Pillow J. Injury and inflammation from resuscitation of the preterm infant.Neonatology 2008;94:190-6.

Jobe AH. Surfactant: The basis for clinical treatment strategies. Bancalari, ed., The Newborn Lung: Questions and Controversies. 73-98, 2008. 

Jobe AH, Kallapur S, Moss TJM. Inflammation/Infection: Effects on the fetal/newborn lung. Bancalari, ed., The Newborn Lung: Questions and Controversies.  119-140, 2008.

Pillow J, Jobe AH. Respiratory Disorders of neonates and infants: Respiratory Disorders of the Newborn. Pediatric Respiratory Medicine, 2nd Edition, 28:365-386, 2008.

Jobe AH. Medical Progress: Hyaline Membrane Disease.J Peds 2007;151:512.

Jobe AH. Drug Pricing in Pediatrics: The Egregious Example of Indomethacin.Pediatrics 2007;119(6):1197-8.

Jobe A. Ventilation strategies-Boston versus elsewhere-revisited.Acta Pediatr 2007;96:8-9.

Professional Organization Memberships

  • Chairman, Steering Committee for NICHD Global Research Network, 2009
  • American Pediatric Society, Secretary-Treasurer, 2003-2009

Special Interests

  • Clinical trials in neonatology
  • Bronchopulmonary Bysplasia

Reviewer for the following journals:

  • Associate Editor, J. Pediatrics
  • Editorial Board, American Journal of Respiratory and Critical Care Medicine-1993-present
  • Editorial Board, American Journal of Physiology-Lung Cellular and Molecular Physiology - 1994-present
  • Editorial Board, Pediatrics - 1995-1997
  • Editorial Board, Journal of Applied Physiology - 1992-1994
  • Editorial Board, Biology of the Neonate - 1986 to 2005

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: