University of Cincinnati Department of Pediatrics

Andrew D. Hershey, MD, PhD, FAHS

Title

Associate Director of Research, Division of Neurology

Appointment

Professor of Pediatrics and Neurology, University of Cincinnati College of Medicine

Email

neuro@cchmc.org

Phone

513-636-4222

Fax

513-636-3980

Bio

Andrew Hershey, MD, PhD, received his undergraduate degree at the University of Iowa, Iowa City, Iowa. He earned an honors degree in Biochemistry; hiss research involved the enzyme kinetic properties of alcohol dehydrogenase in yeast.

After undergraduate school, Dr. Hershey attended the MD/PhD program at Washington University, St. Louis, Missouri. His Ph.D. research thesis was entitled: "The Rat Substance P Receptor: cDNA and Genomic Cloning, Functional Expression, mRNA Distribution, and Mutational Analysis of Desensitization Responses."

After earning his MD and PhD, Dr. Hershey was an intern and resident in pediatrics at St. Louis Children's Hospital, St. Louis, Mo. He then was an adult neurology resident at Barnes-Jewish Hospital, St. Louis, Mo., followed by his child neurology fellowship at St. Louis Children's Hospital, St. Louis, Mo.

After his fellowship, Dr. Hershey joined the faculty at Cincinnati Children's Hospital Medical Center, Ohio, where he is director of the Headache Center.

Dr. Hershey's research interests currently include the improved diagnosis and treatment of childhood headache disorders, characterization of outcome responses, studies in new pharmacological and non-pharmacological treatment regimes, and the neurogenetics of migraines.

Credentials

MD: Washington University, St. Louis, Mo., 1992

PhD: Washington University, St. Louis, Mo., 1992

BS: University of Iowa, Iowa City, Iowa, 1985

Residency: Pediatrics, St. Louis Childrens Hospital, St. Louis, Mo., 1993-1994; Neurology, Barnes-Jewish Hosptial, St. Louis, Mo.,1994-1995

Fellowship: Child Neurology , St. Louis Childrens Hospital, St. Louis, Mo., 1995-1997

Certification: Neurology with special competence in child neurology, 1998, recertified 2008; Headache Medicine, 2006

Awards and Honors

2007 Fellow, American Headache Society
2001/2002 Strathmore's Who's Who, 2001-2002 Millennium Edition
2000 Lexington Who's Who
1997 1997 Annual Meeting Scholarship for Residents
1992 Spencer T. and Ann W. Olin Medical Scientist Fellow
1991 James L. O'Leary Prize for Research in Neuroscience
1985 Honors Certificate of Achievement
1984 to 1985 Ernest R. Johnson Memorial Prize
1984 to 1985 Student Research Fellowship, University of Iowa
1982 to 1984 Scholastic Citation List
1984 to 1985 Univ. of Iowa President's List
1983 to 1985 Univ. of Iowa Dean's List
1982 to 1984 National Dean's List
1983 Dewey B. Stuit Scholarship for Honors Sophomore
1983 University of Iowa Foundation Honors Award
1982 Dewey B. Stuit Freshman Award
1982 Phi Eta Sigma Freshman Honors Society
1981 to 1985 Maytag Company Foundation Award

Research

Epidemiology; diagnositic criteria; treatment evaluation; outcome responses; quality of life issues; pharmaceutical trials; and neurogenetics of childhood headaches.

Research Grants and Contracts

R01 NS045752 Hershey (PI)
07/01/03 - 06/30/07
NIH/NINDS
Genomics of Pediatric Headache Disorders
The aim of this study is to determine whether acute and chronic daily headache patients have similar or different blood genomic profiles.

R01 NS050536 Powers (PI) 07/01/06 - 06/30/10
NIH/NINDS
Drug & Non-Drug Treatment of Pediatric Chronic Headache
Clinical trial to test the efficacy of combined behavioral and pharmacological treatment for youth with chronic headache on two primary endpoints: headache frequency and functional disability.
Role: Co-investigator

American Headache Society, Hershey (PI)
03/01/01 - 06/30/07
Multi-center characterization of pediatric headache - year 1
Longitudinal outcome of pediatric headache and analysis of established criteria - year 2
Obesity in pediatric migraine - year 3
Longitudinal Outcome of Pediatric Chronic Daily Headache - year 4
The aims of these studies are to better characterize pediatric headache using a multi-specialty center approach.
Role: Co-investigator (year 1 and 2), Principal investigator (year 3 and 4)

UCB Pharmacia, Hershey (PI)
10/01/02 - 6/30/07
A retrospective evaluation of the responsiveness of childhood migraines to treatment with levetiracetam.

Tishcon, Inc.
11/01/04 - 06/30/07
CoEnzyme Q10 Supplementation in the Prevention of Childhood Headache
This investigator initiated study is a double blind, placebo-controlled, cross-over study examining the effects of the supplementation with CoEnzyme Q10 on pediatric headache.

Abbott Laboratories Hershey (PI)
8/03 to 5/05 (study site), 8/03 to 5/07 (PedMIDAS)
The Safety and Efficacy of Divalproex Sodium Extended-Release Tablets in Migraine Prophylaxis: A Double-Blind, Placebo-Controlled Study in Adolescents (M02-488)
Role: Local PI and consultant to Abbott Laboratories for study design (PedMIDAS)

Publications, Most Recent

Mack, K.J. and Hershey, A.D. Chronic Daily Headache in Adolescence. A Continuing Problem. Neurology (in press).

Slater, S., Crawford, M.J., Kabbouche, M.A., LeCates, S.L., Biederman, S., Vaughan, P., Segers, A., Manning, P., Burdine, D., Powers, S.W., and Hershey, A.D. Effects of Gender and Age on Pediatric Headache.Cephalalgia (in press).

Hershey, A.D. Patient Page: Teens, Migraine, Suicide, and Suicidal Thoughts.Neurology 72: e61-e64, 2009.

Khatri, R., Hershey, A.D. and Wong, B.W. Prochlorperazine - Treatment for Acute Confusional Migraine. Headache 49: 477-480, 2009.

Hershey, A.D. Menstrual Migraine: How early can it start? Headache 49: 348-349 2009.

Crawford, M.J., Lehman, L., Slater, S., Kabbouche, M.A., LeCates, S.L., Segers, A., Manning, P., Powers, S.W., and Hershey, A.D. Menstrual Migraine in Adolescents.Headache 49: 341-347 2009.

Hershey, A.D., Powers, S.W., Nelson, T.D., Kabbouche, M.A., Winner, P., Yonker, M., Linder, S.L., Bicknese, A., Sowell, M.K., McClintock, W. and the American Headache Society Pediatric and Adolescent Section. Obesity in the Pediatric Headache Population: A Multi-Center Study.Headache 49: 170-177, 2009.

Kabbouche, M.A., Powers, S.W., Segers, A., LeCates, S., Manning, P., Biederman, S., Vaughan, P., Burdine, D., and Hershey, A.D. Inpatient Treatment of Status Migraine with Dihydroergotomine in Children and Adolescents. Headache 49: 106-109, 2009.

Allen, J.R., Crawford, M.J., Sullivan, S.M., Powers, S.W., and Hershey, A.D. CoEnzyme Q10 Deficiency in Adolescent Migraine.Agro Food Industry Hi-Tech. 19:14-15 2008.

Hershey, A.D. Genetics of headache in children: where are we headed? Curr Pain Headache Rep 12:367-372 2008.

Vannatta, K., Getsoff, E.A., Gilman, D.K., Noll, R.B., Gerhardt, C.A Powers, S.W., and Hershey, A.D. Friendships and Social Interactions of School-Aged Children with Migraine. Cephalalgia 28:734-743 2008.

Vannatta, K., Getsoff, E.A., Powers, S.W., Noll, R.B., Gerhardt, C.A and Hershey, A.D. Multiple Perspectives on the Psychological Functioning of Children with and without Migraine. Headache 48:994-1004 2008.

Hershey, A.D., Burdine, D., Liu C., Nick, T.G., Gilbert, D.L., and Glauser, T.A. Assessing quality and normalization of microarrays: case studies using neurological data.Acta Neurol. Scand. 118:29-41 2008.

Lewis, D.W. and Hershey, A.D. Harry Potter’s Headaches.Headache 48: 167-168 2008.

Hershey, A.D., Winner, P., Kabbouche, M.A., and Powers, S.W. Headaches.Curr. Opin. Pediatr. 19:663-669 2007.

Lewis, D.W., Winner, P., Hershey, A.D. and Wasiewski, W.W. Efficacy of zolmitriptan nasal spray in adolescent migraine.Pediatrics 120:390-396 2007.

Gilman, D.K., Palermo, T.M., Kabbouche, M.A., Hershey, A.D. and Powers, S.W. Primary Headache and Sleep Disturbances in Adolescents.Headache 47:1189-1194 2007.

Hershey, A.D. Genetics of Migraine Headache in Children.Curr Pain Headache Rep. 11:390-395 2007.

Winner, P. and Hershey, A.D. Epidemiology and Diagnosis of Migraine in Children.Curr Pain Headache Rep. 11:375-382 2007.

Hershey, A.D. Adolescents with migraine: Nature vs. nurture, Neurology 69:12-13 2007.

Hershey A.D., Powers, S.W., Vockell, A.-L.B., LeCates, S.L., Segers, A., Ellinor, P. L., Segers, A., Burdine, D., Manning, P. and Kabbouche, M.A. CoEnzyme-Q10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine, Headache 47:73-80 2007.

Hershey, A.D., Gladstein, J., and Winner, P. Chronic Daily Headache in the Pediatric Population, Curr Treat Options Neurol 9:14-22 2007.

Winner, P., Powers, S.W., Kabbouche, M.A., and Hershey, A.D., Diagnosing and Managing Headache in Children, Curr Treat Options Neurol 9:3-13 2007.

Hershey, AD, Kabbouche, MA, and Powers, SW. Chronic Daily Headaches in Children.Curr Pain Headache Rep 10:370-376 2006.

Powers, SW, Gilman, DK, and Hershey, AD. Headache and Psychological Functioning in Children and Adolescents.Headache 46:1404-1415 2006.

Powers, SW, Gilman, DK, Hershey, AD and the Headache Center at Cincinnati Children's Hospital Medical Center. Clinical Pearl/Brief Report: Suggestions for a Biopsychosocial Approach to Treating Children and Adolescents who Present with Headache.Headache 46:S149-150 2006.

Sharp, FR, Lit, L, Xu, H, Apperson, M, Walker, W, Wong, B, Gilbert, DL, Hershey, A and Glauser, TA. Genomics of Brain and Blood: Progress and Pitfalls.Epilepsiz 47:1603-1607 2006.

Sharp, FR, Xu, J, Lit, L, Walker, W, Apperson, M, Gilbert, DL, Glauser, TA, Wong, B, Hershey, AD, Liu, D-Z, Pinter, J, Zhang, X, Liu, X, and Ran, R. The Future of Genomic Profiling of Neurological Diseases Using Blood.Arch Neurol 63:1-8 2006.

Professional Organization Memberships

Ohio Headache Association, 2005 to present
American Academy for the Advancement of Science, 2000 to present
Child Neurology Society, 1999 to present
American Headache Society, 1998 to present
International Headache Society, 1998 to present
American Academy of Neurology, 1997 to present
American Academy of Pediatrics, 1992 to present
Society for Neuroscience, 1990 to 1997
American Medical Association, 1985 to 1992
American Medical Student Association, 1985 to 1992
Sigma Xi, Scientific Research Society, 1985

Teaching

"Childhood Headaches: History and Diagnosis" Childhood Headache: School Management at Hamilton County Education Service Center, March 16, 2000.

"Pharmacological Management of Headaches in Children" Childhood Headache: School Management at Hamilton County Education Service Center, March 16, 2000.

"Migraine Management in the Pediatric Patient" Western New York Pediatric Association and Buffalo Pediatric Society, November 16, 2000. Buffalo, New York.

"Management of Pediatric Headache" Children's Hospital of Alabama, University of Alabama, Birmingham, February 1, 2001. Birmingham, Alabama.

"Migraine Classification, Evaluation and Disability" presented as part of Pediatric Migraine Advances and Controversies, Alfred I. DuPont Hospital for Children, The Nemours Foundation, November 16, 2001. Wilmington, Delaware.

"Headaches" Ohio/Kentucky Outreach Series, Cincinnati's Children's Hospital Medical Center, March 14, 2002, March 21, 2002. Cincinnati, Ohio.

"Counterpoint on Special Issues" The 10th Congress of the International Headache Society, June 29, 2001. New York City, New York.

"Treating Migraine Headaches in Children and Adolescents" The 2001 Annual Meeting of the American College of Clinical Pharmacy, October 22, 2001. Tampa, Florida.

Abstracts

Kabbouche, M.A., Hershey, A.D., Powers, S.W., LeCates, S., Ellinor, P. Segers, A., Vockell, A.-L., Manning, P., and Linder, S.L. Combined acute therapy with intravenous dihydroergotamine (DHE) and botulinum toxin A (Botox) in the treatment of chronic intractable headache. Presented at the 48th Annual Scientific Meeting of the American Headache Society, June 22-25, 2006. Los Angeles, CA

Hershey, A.D., Kabbouche, M.A., Rho, Y., Winner, P., Linder, S.L., Yonker, M., Bicknese, A., Sowell, M.K., McClintock, W., Burdine, D., Arnos, C. and Powers, S.W. Obesity in the pediatric headache population: a multi-center study. Presented at the 48th Annual Scientific Meeting of the American Headache Society, June 22-25, 2006. Los Angeles, CA

Rho, Y., Hershey, A.D., Kabbouche, M.A., Powers, S.W., and Glauser, T.A. Epidemiology and clinical characteristics of headache comorbidity with epilepsy in children and adolescents. Presented at the 48th Annual Scientific Meeting of the American Headache Society, June 22-25, 2006. Los Angeles, CA

Hershey, A.D., Kabbouche, M.A., Winner, P., Linder, S.L., Yonker, M.E., and Powers, S.W. Obesity in the Pediatric Headache Population: A Multi-center Study. Oral Presentation at the 49th Annual Scientific Meeting of the American Headache Society, June 7-11, 2007. Chicago, IL

Disabella, M.T., Somers, M.M., Chmelik, E.A., Crawford, M.J., LeCates, S.L., Ellinor, P., Segers, A., Powers, S.W., Manning, P., Hershey, A.D., and Kabbouche, M.A. PAMS (Pediatric and Adolescent Migraine Screen): An Effective Tool to Identify Pediatric Migraine by School Nurses. Presented at the 49th Annual Scientific Meeting of the American Headache Society, June 7-11, 2007. Chicago, IL

Hershey, A.D., Powers, S.W., Kabbouche, M.A., Burdine, D., Glauser, T.A. and Sharp, F.R. Genomic profiles in patients with medication overuse: predicting response. Presented at the XIIIth Congress of the International Headache Society / 13th IHC 2007. June 28-July 1, 2007. Stockholm, Sweden.

DiSabella, M., Somers, M., Chmelik, E., Crawford, M., LeCates, S., Ellinor, P., Segers, A., Powers, S., Manning, P., Hershey, A.D., and Kabbouche, M.A. Changing characteristics in pediatric migraine across developmental ages. Presented at the 36th Annual Meeting of the Child Neurology Society. October 10-13, 2007. Quebec City, Canada.

Books

Hershey, A.D., Powers, S.W., Winner, P., and Kabbouche, M.A. Pediatric Headaches in Clinical Practice. J.W. Wiley and Sons, West Sussex, England, 2009.

Book Chapters

Woeber-Bingoel, C. and Hershey, A.D. “Tension-Type Headaches and Other Primary Headaches in the Pediatric Population” in The Headaches, 3rd Edition, Ed. Olesen, J., Goadsby, P., Ramadan, N., Tfelt-Hansen, P., and Welch, K.M.A. Lippincott, Williams and Wilkins, Philadelphia, PA, USA. 2006.

Hershey, A.D. and Kabbouche, M.A. “Adolescent Headaches” in Adolescent Medicine: Requisites in Pediatrics, Ed. Slap, G.B. Elsevier, Philadelphia, PA, USA. In preparation for 2007 publication.

Hershey, A.D., “Headaches” in the 5th edition of Hoekelman’s Primary Pediatric Care

Hershey, A.D., “Genetics of Migraine Headache” in Headache in Children and Adolescents, 2nd Edition. Eds. Winner, P., Rothner, A.D. and Lewis, D.L. B.C. Decker, Hamilton, Ontario, Canada. 2006

Rothner, A. D., Hershey, A. D. and Pearlman, E. “Secondary Headaches in Children and Adolescents” in Headache in Children and Adolescents, 2nd Edition. Eds. Winner, P., Rothner, A.D. and Lewis, D.L. B.C. Decker, Hamilton, Ontario, Canada. 2006

Hershey, A.D., Gladstein, J. and Winner, P. “Chronic Daily Headaches” in Headache in Children and Adolescents, 2nd Edition. Eds. Winner, P., Rothner, A.D. and Lewis, D.L. B.C. Decker, Hamilton, Ontario, Canada. 2006

Kabbouche, M.A., Hershey, A.D., Qureshi, F., and Lewis, D. “Headache in the Pediatric Emergency Department/Inpatient Management” in Headache in Children and Adolescents, 2nd Edition. Eds. Winner, P., Rothner, A.D. and Lewis, D.L. B.C. Decker, Hamilton, Ontario, Canada. 2006