University of Cincinnati Department of Pediatrics

Brenda Wong, MBBS, MRCP

Title

Child Neurologist

Appointment

Associate Professor of Pediatrics and Neurology

Email

brenda.wong@cchmc.org

Phone

513-636-4222

Fax

513-636-3980

Bio

After medical school, Brenda Wong, MD, received training in General Pediatrics and worked as a pediatrician for a few years before doing her three-year Child Neurology fellowship at Children's Hospital Medical Center, Cincinnati.

Dr. Wong also received training in Pediatric Neuromuscular Disorders at Hammersmith Hospital, London with Dr. Victor Dubowitz and Dr. Francesco Muntoni. Dr. Wong's training in EMGs was accomplished with Dr. John Quinlan at Department of Neurology, University of Cincinnati.

Post fellowship training, Dr. Wong was practicing child neurology in private practice prior to joining Children's Hospital Medical Center of Cincinnati in 1999.

Besides general neurology patients, Dr. Wong sees patients with neuromuscular disorders in the Neuromuscular Clinic and provide diagnostic services like EMGs and evaluation for muscle biopsies. Comprehensive management is supported by the Department of Rehabilitative Medicine, Pulmonary Medicine, Pediatric Orthopedics and the Muscular Dystrophy Association.

Credentials

MD: University of Singapore, 1980.

Residency: University Department of Pediatrics, Singapore, 1981, 1984-85, Royal Hospital for Sick Children, Edinburgh 1985-88.

Fellowship: Child Neurology, Children's Hospital Medical Center, Cincinnati, OH, 1994-97; Neuromuscular Disorders, Hammersmith Hospital, London, 1997.

Certification: Child Neurology, 1998.

Research Grants and Contracts

1-RO1-NS 39327-01A1 Iannaccone (PI), 7/01/00 - 6/30/03, NIH / NINDS Clinical Trials for Pediatric Spinal Muscular Atrophy (SMA)
The goal of this clinical multi-center consortium is to find an effective treatment for SMA. The project develops and refines reliable methods for assessing therapies for SMA.Role: Co-investigator.

Muscular Dystrophy Association Quinlan (PI), 01/01/01 - 12/31/02
Protection of mdx sarcolemma with Poloxamer 188 The project aims to develop an assay of muscle membrane disruption in the mdx mouse and to assess the effectiveness of Poloxamer 188 to protect the dystrophin deficient muscle membrane from breakdown. Role: Co-investigator.

Parent Project Muscular Dystrophy, 5/01/02 - 12/31/02
Contrast agent-enhanced MRI of mdx muscles treated with Poloxamer 188
This study aims to evaluate the use of MS-325, a MRI contrast agent to assess the effectiveness of Poloxamer 188 in stabilizing the dystrophin deficient muscle membrane of MDX mice. Role: PI.

Publications, Most Recent

Outcome measures for pediatric spinal muscular atrophy. AmSMART Group. 6th International Congress of the World Muscle Society, Utah, September 2001. Neuromuscular Disorders 2001; Vol 11, Nos 6-7:646

Wong B, DeGrauw A, Bove K, Hoppel C.: Clinical presentation and muscle morphology of mitochondrial respiratory chain disorders in children. 6th International Congress of the World Muscle Society, Utah, September 2001. Neuromuscular Disorders 2001; Vol 11, Nos 6-7:657

Quinlan J, Wong B.: Exercise induced sarcolemmal damage in mdx mice. 6th International Congress of the World Muscle Society, Utah, September 2001. Neuromuscular Disorders 2001; Vol 11, Nos 6-7:641.

P.H. Tang, M.V. Miles, P Steele, B. Wong, A DeGrauw: Ratios of reduced forms in total coenzyme Q9 and coenzyme Q10 in mice tissues. Clinical Chemistry 2002; Vol 48, No.6, Supplement.