University of Cincinnati Department of Pediatrics

Bruce P. Lanphear, MD, MPH

Title

Director, Cincinnati Children's Environmental Health CenterDirector, Research Fellowship Training Program

Appointment

Adjunct Professor of Pediatrics and Environmental Health

Email

bruce.lanphear@cchmc.org

Phone

513-636-3778

Fax

513-636-4402

Bio

Bruce P. Lanphear, M.D., M.P.H. is the Sloan Professor of Children's Environmental Health and Professor of Pediatrics at Cincinnati Children's Hospital Medical Center and the University of Cincinnati. Dr. Lanphear is director of the Cincinnati Children's Environmental Health Center located at Cincinnati Children's. He is a member of the U.S. EPA's Clean Air Scientific Advisory Committee Lead Review Panel and a Member of the National Children's Study Steering Committee.

Dr. Lanphear is currently principal investigator for a study examining fetal and early childhood exposures to prevalent environmental neurotoxins including lead, pesticides, mercury, alcohol, PCB's and environmental tobacco smoke. A component of the study is the investigation of the contribution of residential hazards and residential injuries to children's health.
This project recently received funding to follow the original birth cohort another five years, until the children are five years of age. This will allow follow-up for determining the efficacy of lead hazard controls on children's blood lead levels and their risk for learning and behavioral problems.

Dr. Lanphear has extensive experience conducting community-based trials, including lead poisoning prevention, epidemiology of asthma, prevention of exposure to tobacco smoke and measurement of lead and allergens in housing.

Credentials

MD: University of Missouri at Kansas City, 1986.
Residency: General Preventive Medicine & Public Health, Tulane School of Public Health & Tropical Medicine, New Orleans, LA.
Certification: General Preventive Medicine and Public Health, 1992.

Awards and Honors

Testimony, Vermont State Legislature, "The Lingering Legacy of Lead Toxicity," Montpelier, Vermont, February 1, 2007.

Invited Member, Council of Fellows of the Collegium Ramazzini.

Appointed to the Julius B. Richmond Center of Excellence External Scientific Advisory Committee, Richmond Center for Excellence in Tobacco Research, American Academy of Pediatrics.

Invited Participant, "How Does Housing Affect Health Outcomes of Children?", MacArthur Foundation, Chicago, Illinois, June 21-22, 2006.

Member, National Children's Study Steering Committee.

Member, U.S. EPA's Clean Air Scientific Advisory Committee Lead Review Panel.

Invited Participant, NIEHS Strategic Planning Forum, National Institute for Environmental Health Sciences, Chapel Hill, North Carolina, October 17-18, 2006.

Research

Children's environmental health
Environmental neurotoxins, including lead, mercury, pesticides and environmental tobacco smoke
Asthma prevention
Gene-environment interactions.

Research Grants and Contracts

Principal Investigator; A Community-Based Trial to Prevent Lead Poisoning and Injuries, R01-ES014575; 4/1/07–3/31/12.

Principal Investigator, subcontract; National Children's Study Vanguard Center; 11/1/05–10/31/10.

Principal Investigator; Study of Prevalent Neurotoxicants in Children (Supplement 2), ES011261-05S2; 9/1/05–8/31/07.

Program Director; National Research Service Award (Training Grant), T32PE10027; 7/1/03–6/30/08.

Co-Investigator; Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood, R21ES015517; 12/1/07–11/30/12.

Co-Investigator; Tobacco Smoke and Early Human Neurobehavior, FAMRI Clinical Innovator Award; 7/1/07–6/30/10.

Co-Investigator; Epithelial Genes in Allergic Inflammation, U19AI70235-01; 7/1/06–6/30/11.

Co-Investigator; Neurobehavioral Effect of Low Level Manganese Exposure: Correlation and Validation of a Novel Biomarker, R21-ES013524; 12/1/05–11/30/07.

Co-Investigator & Mentor; Tobacco Smoke Exposure and the Formation of Pre-Cancerous Compounds in Tobacco-Exposed Children, K01 CA123355; 7/1/07–6/30/12.

Co-Investigator & Mentor; Low Level Prenatal Tobacco Exposure & Infant Wheeze, FAMRI Young Clinical Scientist Award; 7/1/07–6/30/10.

Co-Investigator & Mentor; Exhaled Nitric Oxide to Manage Childhood Asthma, R21HL083145; 7/1/06–6/31/08.

Co-Investigator & Mentor; Racial Differences in Cancer Biomarkers Following Exposure to Environmental Tobacco Smoke, UC Dean's Scholars Award; 7/1/06–6/30/09.

Co-Investigator & Mentor; Role of Environmental Chemicals on Lactation Outcomes, K23 ES014691; 6/1/06–5/30/11.

Co-Investigator & Mentor; Childhood Residential Injury and Caregiver Supervision, K23 HD045770; 4/1/05–3/31/10.

Co-Investigator & Mentor; Childhood Asthma in an Era of Genomics: Will the Generalist's Role be Recast?; 6/1/04–5/30/08.

Co-investigator; Early Lead Exposure, ADHD & Persistent Criminality: Role of Genes & Environment, R01-ES015559; 4/1/07–3/31/12.

Funded Training Programs

Health Resources and Health Services Administration (HRSA), National Research Service Award – Research Fellowship Training Program in General Pediatrics and Adolescent Medicine, 7/01/98 to 6/30/08.

Publications, Most Recent

Wilson, S.E., Kahn, R.S., Khoury, J., Lanphear, B.P. The role of air nicotine in explaining racial differences in cotinine among tobacco-exposed children. Chest, 2007; 131:856-862.

Swanson, J.M., Kinsbourne, M., Nigg, J., Lanphear, B., Stefanatos, G.A., Volkow, G., Taylor, E., Casey, B.J., Castellanos, F.X., Wadhwa, P.D. Etiologic subtypes of attention-deficit/hyperactivity disorder: Brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychol Rev, 2007; 17:39-59.

Lanphear, B.P., Paulson, J., Beirne, S. Trials and tribulations of protecting children from environmental hazards. Environ Health Perspect, 2006; 114:1609-1612.

Braun, J.M., Kahn, R.S., Froehlich, T., Auinger, P., Lanphear, B.P. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ Health Perspect, 2006; 114:1904-1909.

Yuan, W., Holland, S.K., Cecil, K.M., Dietrich, K.N., Wessel, S.D., Altaye, M., Hornung, R.W., Ris, M.D., Egelhoff, J.C., Lanphear, B.P. The impact of early childhood lead exposure on brain organization: A functional magnetic resonance imaging study of language function. Pediatrics, 2006; 118:971-977.

Spanier, A.J., Hornung, R., Lierl, M., Lanphear, B.P. Environmental exposures and exhaled nitric oxide in children with asthma. J Pediatr, 2006; 149:220-226.

Presentations, Most Recent

Lanphear, B.P. Childhood lead exposure, cognitive ability, and genotype in ADHD and antisocial behavior. Presented at the International Society for Research in Child & Adolescent Psychopathology 13th Scientific Meeting; June 21, 2007; London.

Lanphear, B.P. Linking low-level neurotoxicant exposures of the developing brain to learning and behavioral problems. Presented at the International Conference on Developmental Programming and Effects of Environmental Toxicants in Human Health and Disease; May 20, 2007; Faroe Islands.

Lanphear, B.P. Efficacy of HEPA-CPZ air cleaners on unscheduled asthma visits and asthma symptoms. Presented at the Pediatric Academic Societies Annual Meeting, APA Presidential Platform Plenary Session, May 7, 2007; Toronto, Canada.

Lanphear, B.P. Linking low-level exposures to environmental toxicants with ADHD. Presented at the Duke Integrated Toxicology and Environmental Health Program Symposium on Developmental Neurobehavioral Disabilities and Toxic Exposures; March 23, 2007; Durham, NC.

Lanphear, B.P. Integrating genetic and environmental influences in epidemiology using biomarkers. Presented at Community and Preventive Medicine Ground Rounds at the Mount Sinai Medical School; March 1, 2007, New York, NY.

Lanphear, B.P. The epidemiologic conquest of childhood lead toxicity: A pyrrhic victory. Presented at the NIEHS Workshop on Children's Environmental Health Research: Past, Present and Future; January 22, 2007; Durham, NC.

Lanphear, B.P. Low-level lead toxicity: The ongoing search for a threshold. Presented at the National Environmental Public Health Conference, National Centers for Disease Control; December 4, 2006; Atlanta, GA.

Lanphear, B.P. Low-level lead toxicity: Implications for prevention. Presented at the WHO Informal Workshop on Lead, University of Munich; November 30, 2006; Munich, Germany.

Lanphear, B.P. Ethical dilemmas in children's environmental health. Presented at a Seminar Series in Ethics of Toxicology, University of Champagne-Urbana; November 19, 2006; Champagne, IL.

Lanphear, B.P. The legacy of lead. Presented at the Indiana Lead Conference; October 24, 2006; Indianapolis, IN.

Lanphear, B.P. Integrating genetic and environmental biomarkers in pediatric epidemiology. Visiting Professor at Simon Fraser University and University of British Columbia; October 19-20, 2006; Vancouver, British Columbia.

Lanphear, B.P. Protecting children from environmental toxins. Presented at the Region VIII Children's Environmental Health Summit; September 20, 2006; Vail, CO.

Lanphear, B.P. Efficacy of HEPA-CPZ air cleaners on unscheduled asthma visits and asthma symptoms. Presented at the International Society for Environmental Epidemiology; September 6, 2006; Paris, France.

Lanphear, B.P. Low-level lead toxicity: The ongoing search for a threshold. Presented at the International Workshop on Neurotoxic Metals: From Research to Prevention, University of Brescia; June 17, 2006; Brescia, Italy.

Lanphear, B.P. Ethical issues in housing health hazard research involving children. Topic Symposia, presented at the Pediatric Academic Societies Annual Meeting; May 2, 2006; San Francisco, CA.

Lanphear, B.P. Integrating genetic and environmental influences in pediatric research. Moderator and speaker, presented at the Pediatric Academic Societies Annual Meeting; April 30, 2006; San Francisco, CA.

Lanphear, B.P. Trials and tribulations of protecting children from environmental hazards: Ethical issues. Presented at Johns Hopkins University of Medicine; March 17, 2006; Baltimore, MD.

Lanphear, B.P. Key elements of a primary prevention strategy for lead poisoning. Presented at the Albany Law School, Union University; March 16, 2006; Albany, NY.

Lanphear, B.P. Low-level lead toxicity: The ongoing search for a threshold. Presented at Case Western Reserve University, City Club of Cleveland; March 4, 2006; Cleveland, OH.

Lanphear, B.P. The role of biomarkers in revealing genetic and environmental influences of disease and disability. Presented at Psychiatry Grand Rounds; February 8, 2006; Cincinnati, OH.

Professional Organization Memberships

Teaching

Principal Investigator, "National Research Service Award - Fellowship Training in General Pediatrics and Adolescent Medicine" [1T32PE10027), Health Resources and Services Administration, Department of Health and Human Services. 07/01/03 to 06/30/09; $1,600,000. (0% effort).