Cong Yan, PhD
Appointment
Associate Professor
Email
cong.yan@cchmc.org
Phone
513-636-2996
Fax
513-636-7868
Credentials
BSc: Virology, Wuhan University, China
MSc: Biochemistry, City University of New York
PhD: Biochemistry, City University of New York
Fellowship: Molecular Biology, The Rockefeller University, New York
Research
The lung originates as a diverticulum from the foregut. In early lung development, the primitive lung is a small epithelial tubule surrounded by mesenchymal cells. Through the interaction with mesenchymal cells, lung epithelium undergoes multiplication of branches and subsequently forms airways and alveoli, forming proximal and distal structures. This process is dependent and influenced by many signaling molecules through paracrine/autocrine mechanisms.
Dr. Cong Yan's research focuses on biochemical, cellular and physiological functions of signal transduction pathways and transcription factors critical to lung development and tissue-specific gene regulation.
Research Grants and Contracts
1999-2007 R01 HL61803-01, NIH/NHLBI, Principal investigator, "Genetic control of SP-B Gene Expression in the lung".
2002-2005 March of Dimes Foundation, Principal investigator, "Transcriptional Regulation of Surfactant Protein B Gene by STAT3 in the Lung"
2003-2007 1 R01 HL67862, NIH/NHLBI, Principal investigator, "Nuclear Receptor Co-Activators in the Lung"
Publications, Most Recent
Naltner, A.; Ghaffari, M.; Whitsett, J. A.; and Yan, C. : Retinoic Acid Stimulation of the hSP-B Promoter Is TTF-1 Site Dependent (2000).J. Biol. Chem. 275(1):56-62.
Naltner, A.; Wert, S.; Whitsett, J. A.; and Yan, C. : Temporal/Spatioal Expression of Nuclear Receptor Coactivators in the Mouse Lung (2000).Am. J. of physiology, 279: L1066.
Yan C., Naltner, A., Conkright, J. and Ghaffari, M.: Protein-protein interaction of RARa and TTF-1 in Respiratory Epithelial Cells (2001). J. Biol. Chem. 276(24): 21686-21691.
Angela Naltner, Manely Ghaffari, Jeffery A. Whitsett and Cong Yan (corresponding author): Retinoic Acid Stimulation of the hSP-B Promoter Is TTF-1 Site Dependent (2000). J. Biol. Chem. 275(1):56-62.
Angela Naltner, Susan Wert, Jeffery A. Whitsett and Cong Yan (corresponding author): Temporal/Spatioal Expression of Nuclear Receptor Coactivators in the Mouse Lung (2000). Am. J. of physiol. 279: L1066.
Cong Yan (corresponding author), Angela Naltner, Conkright, J. and Ghaffari, M.: Protein-protein interaction of RARa and TTF-1 in Respiratory Epithelial Cells (2001). J. Biol. Chem. 276(24): 21686-21691.
Cong Yan (corresponding author), Angela Naltner, Michelle Martin, Michael Naltner, Jessica M. Fangman and Oky Gurel: Transcriptional Stimulation of the Surfactant Protein B Gene by STAT3 in Respiratory Epithelial Cells (2002). J. Biol. Chem. 277(13): 10967-10972.
Li Yang, Angela Naltner, Allison Kreiner, Dong Yan, Angelynn Cowen, Hong Du and Cong Yan (corresponding author): An Enhancer Region Determines hSP-B Gene Expression in Bronchiolar and Alveolar Type II Epithelial Cells in Transgenic mice (2003). Am. J. of physiol. 284: L481-488.
Li Yang, Angela Naltner and Cong Yan (corresponding author): Overexpression of dnRARa Causes Alveolar Abnormality in Transgenic Neonatal Lungs (2003). Endocrinology, 144(7) 3004-3011.
Li Yang, Dong Yan, Cong Yan (corresponding author) and Hong Du: PPARg and ligands inhibit SP-B Gene Expression in the Lung (2003). J. Biol. Chem. 278(38): 36841-36847.
Xuemei Lian, Cong Yan (corresponding author), Li Yang, Yan Xu and Hong Du: Lysosomal Acid Lipase Deficiency Causes Respiratory Inflammation and Destruction in the Lung (2004). Am. J. of Physiol. 268:L801-807.
Li Yang, Xuemei Lian, Angelynn Cowen, Huan Xu, Hong Du and Cong Yan: Synergy between STAT3 and RARa in Regulation of the Surfactant Protein B Gene in the Lung (2004).Mol Endocrinol, 18(6):1520-32.
Cong Yan and Hong Du: Highlighted Topic in Lung Growth and Repair: Alveolus formation - what have we learned from genetic studies (Review) (2004). Journal of Applied Physiology, In Press.
Li Yang, Dong Yan, Molly Bruggeman, Hong Du and Cong Yan (corresponding author): Mutation at A Lysine Acetylation Site in Homeodomain Generates Dominant Negative TTF-1 (2004). Biochemistry, In Press.
Professional Organization Memberships
- American Society for Biochemistry and Molecular Biology
- American Society for Cell Biology
Special Interests
Molecular biology, biochemistry, lung biology.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
