University of Cincinnati Department of Pediatrics

Daniel W. Nebert, MS, MD

Appointment

Professor, University of Cincinnati College of Medicine

Email

dan.nebert@uc.edu

Phone

513-558-4347

Fax

513-558-3562

Bio

International leader in elucidation of the diversity, specificity, functions, evolution and nomenclature of several drug-metabolizing enzyme gene superfamilies and their role in metabolism of endogenous substrates as well as of foreign chemicals; mechanisms by which pharmacogenetics and pharmacogenomics determine susceptibility to toxicity, teratogenicity and carcinogenicity by environmental agents including pharmaceuticals; gene-drug interactions; gene-environment interactions.

Credentials

MS and MD: Oregon Health Sciences University, Portland, Ore., 1964

Residency: Pediatrics, UCLA, Los Angeles

Board-qualified: Pediatrics, 1968

Board-qualified: Human genetics, 1985

Research

Genetics, molecular pharmacology, toxicology, teratogenesis, carcinogenesis, signal transduction pathways, evolution, genomics, gene & allele nomenclature.

Publications, Most Recent

Nebert DW. (2005) Role of host susceptibility to toxicity and cancer caused by pesticides: cytochromes P450.J Biochem Mol Toxicol 19:184-6.

Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW. (2005) Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.Hum Mutat 25:196-206.

Derkenne S, Curran CP, Shertzer HG, Dalton TP, Dragin N, Nebert DW. (2005) Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.Pharmacogenet Genomics 15:503-11.

Shen D, Dalton TP, Nebert DW, Shertzer HG. (2005) Glutathione redox state regulates mitochondrial reactive oxygen production.J Biol Chem 280:25305-12.

Dalton TP, He L, Wang B, Miller ML, Jin L, Stringer KF, Chang X, Baxter CS, Nebert DW. (2005) Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis.Proc Natl Acad Sci U S A 102:3401-6.

Liu H, Zhang S, Lin J, Li H, Huang A, Xiao C, Li X, Su Z, Wang C, Nebert DW, Zhou B, Zheng K, Shi J, Li G, Huang D. (2005) Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.Metabolism 54:568-72.

Greaves P, Clothier B, Davies R, Higginson FM, Edwards RE, Dalton TP, Nebert DW, Smith AG. (2005) Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.Biochem Biophys Res Commun 331:147-52.

Mackenzie PI, Walter Bock K, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW. (2005) Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.Pharmacogenet Genomics 15:677-85.

Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP. (2005) Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.J Biol Chem 280:33766-74.

Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ. (2005) Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.Chem Res Toxicol 18:1471-8.

Nebert DW. (2005) Inter-individual susceptibility to environmental toxicants-A current assessment.Toxicol Appl Pharmacol 207:34-42.

Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW. (2006) Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.Mol Pharmacol 69:1103-14.

Genter MB, Clay CD, Dalton TP, Dong H, Nebert DW, Shertzer HG. (2006) Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.Biochem Biophys Res Commun 342:1375-81.

Curran CP, Miller KA, Dalton TP, Vorhees CV, Miller ML, Shertzer HG, Nebert DW. (2006) Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.Toxicol Sci 89:454-64.

Li Y, Zhang D, Jin W, Shao C, Yan P, Xu C, Sheng H, Liu Y, Yu J, Xie Y, Zhao Y, Lu D, Nebert DW, Harrison DC, Huang W, Jin L. (2006) Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.J Clin Invest 116:506-11.

Nebert DW. (2006) Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on "development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes".Am J Physiol Cell Physiol 290:C37-41.

He L, Girijashanker K, Dalton TP, Reed J, Li H, Soleimani M, Nebert DW. (2006) ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.Mol Pharmacol 70:171-80.

Dragin N, Dalton TP, Miller ML, Shertzer HG, Nebert DW. (2006) For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.J Biol Chem 281:18591-600.

Genter MB, Marlowe J, Kevin Kerzee J, Dragin N, Puga A, Dalton TP, Nebert DW. (2006) Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs.Biochem Biophys Res Commun.

Zhang G, Nebert DW, Chakraborty R, Jin L. (2006) Statistical power of association using the extreme discordant phenotype design.Pharmacogenet Genomics 16:401-413.

Vasiliou V, Ross D, Nebert DW. (2006) Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family.Hum Genomics 2:329-35.

Jiang Z, Dragin N, Jorge-Nebert LF, Martin MV, Guengerich FP, Aklillu E, Ingelman-Sundberg M, Hammons GJ, Lyn-Cook BD, Kadlubar FF, Saldana SN, Sorter M, Vinks AA, Nassr N, von Richter O, Jin L, Nebert DW. (2006) Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenet Genomics 16:359-67.