University of Cincinnati Department of Pediatrics

David Neal Franz, MD

Title

Director, Tuberous Sclerosis Clinic, Associate Director of Clinical Affairs, Division of Neurology

Appointment

Professor of Pediatrics and Neurology, University of Cincinnati College of Medicine

Email

franz@cchmc.org

Phone

513-636-4222

Fax

513-636-1888

Bio

David Neal Franz, MD, was born and raised in Dayton, Ohio. He received his undergraduate degree in History and Literature from Earlham College in Richmond, Indiana.

After completing his training he served as Assistant Professor of Neurology and Pediatrics at Wright State University before returning to Cincinnati Children's Hospital Medical Center.

He established the Cincinnati Tuberous Sclerosis Clinic in 1993, to assist in the medical care of patients who have or are suspected of having tuberous sclerosis. The purpose of the clinic is not to replace care from the child's pediatrician or family physician, but to assist the primary care physician in dealing with those aspects unique to tuberous sclerosis that affect the child's health or development. The basis of the clinic is the realization that people with tuberous sclerosis are different from other individuals who have epilepsy, learning disabilities, behavior problems, etc.

For too long, the unique problems found in this disease have been lumped together with similar disorders, despite the fact that research has shown that disorders of the brain, heart, kidney, and other organs in tuberous sclerosis are quite different.

Credentials

MD: Ohio State University College of Medicine, Columbus, OH, 1985.

Residency: Pediatrics, Wright State University Affiliated Hospitals, Dayton, OH.

Fellowship: Neurology, Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1990; Neurology with special competence in child neurology, 1992.

Awards and Honors

Best Doctors in America, 2008
Awarded "2005 Best Doctors"
Awarded "2004 Best Doctors"
Cincinnati Magazine Best Doctors, Pediatric Neurology, 2002, 2004, 2005, 2007, 2008, 2009

Research Grants and Contracts

Rapamycin therapy of renal angiomyolipomas in patients with tuberous sclerosis complex and sporadic lymphangioleiomyomatosis, TS Alliance, LAM Foundation, 2003, 2004.

Publications, Most Recent

Schmithorst V, Altes T, Young L, Franz D, et al. Automated Algorithm for Quantifying the Extent of Cystic Change on Volumetric Chest CT: Initial Results in Lymphangioleiomyomatosis. Cardiopulmonary Imaging American Roentgen Ray 2009 Apr..

Bissler JJ, McCormack F, Young L, Elwing J, Chuck G, Leonard J, Schmithorst V, Laor T, Brody A, Bean J, Salisbury S, Franz DN. Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis. The New England Journal of Medicine 2008 January;358(2):140-151.

Krueger DA, Franz DN. Current Management of Tuberous Sclerosis Complex.Pediatric Drugs 2008; =(10)5.

Pandolfi, P Ma L, Franz DN, et al. Identification of S664 TSC2 Phosphorylation as a Marker for Erk-Mediated mTOR Activation in Tuberous Sclerosis and Human Cancer. Cancer Res 2007 Aug;67(15):7106-12.

Madhavan D, Schaffer P, Yankovsky A, Arzimanoglou A, Renaldo F, Zaroff C, LaJoie J, Weiner H, Andermann E, Franz DN, Leonard J, Connolly M, Cascino G, Devinsky O. Surgical Outcome in Tuberous Sclerosis Complex; A Multicenter Survey. Epilepsia 2007 May.

Kozlowski P, Roberts P, Dabora S, Franz DN, et al. Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations. Human Genetics 2007 May(3-4): 389-400.

Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, et al. Identification of S664 TSC2 Phosphorylation as a Marker for Extracellullar Signal-Regulated Kinase Mediated mTOR Activation in Tuberous Sclerosis and Human Cancer. Cancer Research 2007 Aug; 67(15):7105-12.

Professional Organization Memberships

Abstracts

Young L, Gulleman P, Kinder BW, Vandyke R, Chuck G, Inoue Y, Bissler J, Franz D, Trapnell B, McCormack F. Serum VEGF-D is a Diagnostic Test for Lymphangioleiomyomatosis. American Thoracic Society, October, 2007.

Fujiwara H, Rose D, Lee K, Mangano F, Hemasilpin N, Franz D. Comparison of MEG and Intracranial EEG source Localization with Multiple Algorithms in Patients with Tuberous Sclerosis Complex. ISACM, 2009.