University of Cincinnati Department of Pediatrics

Hermine I. Brunner, MD, MSc

Appointment

Associate Professor of Pediatric Rheumatology

Email

hermine.brunner@cchmc.org

Phone

513-636-4676

Fax

513-636-4116

Bio

Dr. Brunner is a pediatric rheumatologist with a special clinical and research interest in pediatric lupus. Her research is focused on biomarker discovery and the testing of new medications for lupus. She is also involved in trial design and provides statistical support at CCHMC. As head of the Lupus Center, she is involved in the conduction of the Lupus Clinic and the organization of Lupus Support Groups. She also pioneers the development of outcome measures and improving the quality of clinical of children with lupus and other rheumatic diseases.

Credentials

MD: Ludwig Maximilan University, Munich, Germany, 1991

Residency: University of Chicago, 1997

Fellowship: University of Toronto & Cincinnati, 1999

MSc: Clinical Epidemiology: University of Toronto, 1999

Certification: Pediatrics 1997; Rheumatology 2002

Position History

Pediatric residency, Dr. von Haunersches Kinderspital, Munich, Germany, 1992-1993

Emergency Medical Care, Province Cunene, Angola, 1993-1994

Pediatric residency, Wyler Children's Hospital, Chicago, USA, 1994-1997

Pediatric rheumatology fellowship, Hospital for Sick Children, Toronto, Canada, 1997-1999

Pediatric rheumatology fellowship, Cincinnati Children's Hospital Medical Center, USA, 1999-2000

Research Associate, Cincinnati Children's Hospital Medical Center, USA, 2000-2001

Instructor of Pediatrics, Cincinnati Children's Hospital Medical Center, USA, 2001-2003

Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, USA, 2003-2007

Associate Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, USA, 2003-2007

Awards and Honors

National student representative of Friedrich Ebert Foundation
Student representative of Council of Medicine, Ludwig Maximillians University, Munich
Magna cum laude. Dissertation at Faculty of Medicine, Ludwig Maximillians University, Munich
Society of Clinical Decision Making member
Arthritis Foundation, member, presentations, volunteer
International Society of Pharmacoeconomics; member
NIH/NIAMS Study Section
Assistant director MCRC Methodology Core
Scientific Director Pediatric Rheumatology Collaborative Study Group

Research

Economic analyes
HRQOL
Measurement development
Outcome research
Lupus

Research Grants and Contracts

U01-AR51868 (Brunner) 09/30/04- 9/29/08 "Meaningful Outcomes of Pediatric Lupus Clinical Trials"
The major goal of the project is to develop surrogate markers for pediatric SLE clinical trials in collaboration various pediatric rheumatology research groups.

Alliance for Lupus Research (Brunner) 1/1/06- 3/30/08 "Towards Biomarkers for Lupus Renal Disease"
The major goal of the project is to identify and validate biomarkers for SLE using proteomics and to establish the predictive properties of neutrophil gelatinase associated lipocalin (NGAL) to serve as renal biomarker of SLE.

CCHMC Translational Research Initiative (Brunner) 07/01/07 – 6/30/08 "Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid"
The major goal of the project is to pharmacokinetic, pharmacodynamic and pharmacogenetic markers of MMF response in SLE.

U01 AR06-006 (Brunner) 10/01/07 – 09/30/10 "Clinical Trials Outcomes for Pediatric Lupus Trials"
The major goal of this project is develop criteria of remission and flare as well as a National CARRA Lupus Registry.

P035278 Department of Defense (Devarajan) 07/01/2007 – 6/30/2010 "Early Biomarkers for Lupus Nephritis"
The major goal of the project is to identify and validate biomarkers for SLE using proteomics

CCHMC Health-Services Matrix (Brunner) 01/01/08 – 12/30/10
"Improving Adherence To Medical Interventions In Childhood-Onset Lupus."
The major goal of the project is to use interventions at the level of the health delivery system for improving visit and medication adherence in children, adolescent and young adults with SLE.

Publications, Most Recent

M. Suzuki, K. M. Wiers, M. Klein-Gitelman, K. A. Haines, J. Olson, K.B. Onel, K. O'Neil, M.H. Passo, N.G. Singer, L. Tucker, J. Ying, P. Devarajan, H.I. Brunner. Neutrophil Gelatinase Associated Lipocalin as a Biomarker of Disease Activity In Pediatric Lupus Nephritis; Pediatr Nephrol. 2008 Jan 17( epub).

S. Koneru, L Kochrala, G. C. Higgins, A. Ware, M. H. Passo, Y. D. Farhey, A-B Mongey, T.B. Graham, J.L. Houk, and H. I. Brunner. Adherence to medications in systemic lupus erythematosus. Journal of Clinical Rheumatology; 2008: in press.

H.I. Brunner, D. D. Gladman, D. Ibañez, M. D. Urowitz, E. D. Silverman: Difference in disease features between childhood-onset and adult systemic lupus erythematosus (SLE).Arthritis Rheum 2008; 56: in press.

E. Sommers, H.I. Brunner. L. Nabors. Pain, Fatigue, Family Functioning, and Attitude Toward Illness in Children with Juvenile Rheumatic Diseases. J Dev Phys Disabil. 2007; 18: in 11-23.

L Nabors, E Jobst, J Wesiman, B. Precht, P Chiu, H.I. Brunner. School support and Functioning for Childrewith Juvenile Rheumatic Diseases. J. Dev Phys Disabil DOI 10.1007.

Bleesing J, Prada E, Siegel DM, Villanueva J, Olson J, Ilowite N, Brunner HI, Griffin T, Graham TB, Sherry DD, Passo MH, Filipovich A, and Grom AA. The Diagnostic Significance of soluble CD163 and soluble IL2Ra chains in Macrophage Activation Syndrome and Untreated New Onset Systemic Juvenile Idiopathic Arthritis. Arthritis Rheum 2007, p965 -971

S. Koneru, M. Shishov, A. Ware, Y. Farhey, A. B. Mongey, J. L. Houk, and H.I. Brunner. Effectively Measuring Adherence to Medications For Systemic Lupus Erythematosus In A Clinical Setting. Arthritis Rheum 2007, 57: 1000-1006.

Mikdashi (Co-Chair), JM Esdaile (Co-Chair), GS Alarcón (Co-Chair), L Crofford, BJ Fessler, L Schanberg, H Brunner, V Gall, JR Kalden, MD Lockshin, MH Liang, N Roberts Jr and M Schneider; for the Ad Hoc Committee on Lupus Response Criteria: Cognition Sub-committee: Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials. Lupus (2007) 16, 418–425.

H. I. Brunner, N. M. Ruth, A. German, S. Nelson, M.H. Passo, T. Roebuck-Spencer, J. Ying, D. Ris. Initial validation of the pediatric automated neuropsychological assessment metrics for childhood-onset systemic lupus erythematosus. Arthritis Rheum 2007, 57: 1174-1182.

Suzuki, K.Wiers, S Nelson, C Rutherford, P Devarjan, H I Brunner: Identification of urinary proteomic signature for nephritis in children. Pediatr Nephrol. 2007 Dec; 22(12):2047-2057.

M. DiFrancesco, S. Holland, D. Ris C. Adler, M. DeBello, M. Altaye, H.I. Brunner. Functional magnetic resonance imaging of cognitive function in childhood-onset systemic lupus erythematosus: a pilot study. Arthritis Rheum. 2007 Dec;56 (12):4151-63.

H.I. Brunner, T.M. Sherrard, M. Klein-Gitelman: Cost of care of children with systemic lupus Erythematosus. Arthritis & Rheum 2006, 55: 184-188.

H.I. Brunner, A. Bishnoi, A. C. Barron, L. J. Houk, A. Ware, Y. Farhey, A. B. Mongey, C. F. Strife, T. B. Graham, M. H. Passo. Long-term outcomes and ovarian function in childhood-onset Systemic lupus erythematosus (cSLE).Lupus 2006; 15: 198-206.

H. I. Brunner, J. Taylor, M. T. Britto, M. S. Corcoran, S. L. Kramer et al. Differences in disease outcomes between Medicaid and privately insured children: possible health disparities in juvenile rheumatoid arthritis (JRA).Arthritis Rheum 2006; 55: 378-384.

H. I. Brunner, M Mueller, C Rutherford, M H Passo, A A Grom, J Mishra, P Devarajan. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker of Nephritis in Childhood-onset Systemic Lupus Erythematosus. Arthritis Rheum 2006; 54(8):2577-2584

M Chaudari, M Moroldo, S. K. Thompson, P. Hillard, B Huang, H.I. Brunner, D.N. Glass: Decreased reproductive fitness in childhood autoimmune arthropathy families. Rheumatology 2006; Advanced Access; doi:10.1093.

H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Baldwin, M. Trombley, et al: Minimal clinically important differences of the childhood health assessment questionnaire(CHAQ).J Rheumatology; 2005; 32: 150-162.

B. Carey; M. DeLay; J E. Strasser; C. Chalk; K. Dudley-McClain; G. N. Milligan; H.I. Brunner; S. Thornton; and R. Hirsch. A Soluble Divalent Class I MHC/IgG Fusion Protein Activates CD8+T Cells in vivo.Clinical Immunology, 2005 Jul;116(1):65-76

G. D. Myer, H. I. Brunner, P. G. Melson, M. V. Paterno K. R. Ford, T. E. Hewett. Improved neuromuscular function and biomechanics with specialized neuromuscular training in a patient with quiescent juvenile idiopathic arthritis: a case report. Physical Therapy Journal 2005 Aug; 85(8):791-802.

H I Brunner, A C Barron, L Johnson, T B Graham, M H Passo, T Jackson, and D J Lovell. Gastrointestinal (GI) symptoms and their association with health related quality of life of children with juvenile rheumatoid arthritis (JRA) – validation of a GI symptom questionnaire. Physical Therapy Journal 2005; 85 (8); 791-802.

C.V. Oddis, L. G. Rider, A. M. Reed, N. Ruperto, H. I. Brunner, B. Koneru, B. M. Feldman, E. H. Giannini, F. W. Miller for the International Myositis Assessment and Clinical Studies Group (IMACS).Arthritis & Rheumatism 2005, 52; 2607-15..

N. Fall, K.E. Bove, K. Stirnger, D.J. Lovell, H.I. Brunner, N.T. Ilowite, G.C. Higgins, S.L. Bowyer, T.B. Graham, S. Thornton, and A. Grom. Lack of angiogenic response in muscle tissues form patients with juvenile dermatomyositis is associated with high expression of angiostatic ELR-negative CXC-chemokines: Possible link to vasculopathy. Arthritis Rheum 2005; 52:3175-80.

D.A. De Albuquerque, V. Saxena, D. E. Adams, G. P. Boivin, H. I. Brunner, D. P. Witte, R. R. Singh. An ACE inhibitor reduces Th2 cytokines and TGFb-1 and -2 isoforms in murine lupus nephritis. Kidney International. 2004; 65: 846-859.

H.I. Brunner, N. Ruperto. Outcome Measures for Childhood-onset Systemic Lupus Erythematosus (cSLE). Pediatric Rheumatology Online Journal; 2004 (2): May/June.

L. G. Rider, E. H. Giannini, H. I. Brunner, N. Ruperto, L. J.-Newton, A. M. Reed, P. A. Lachenbruch, F. W. Miller , for the International Myositis Assessment and Clinical Studies Group (IMACS). International Consensus Outcome Measures for Patients with Idiopathic Inflammatory Myopathies. Preliminary Definitions of Improvement for Adult and Juvenile Myositis.Arthritis & Rheumatism 2004; 50: 2281-90.

H.I. Brunner, M.S. Klein-Gitelman, M.J. Miller, N. Baldwin, M. Trombley, et al: Health of children with chronic musculoskeletal diseases: relationship of different measures and the quality of parent-proxy reporting. Arthritis & Rheumatism 2004; 51: 763-773.

A C Barron, T-L Lee, J Taylor, T Moore, M H Passo, T B Graham, T A Griffin, A A Grom, D J Lovell, and H I Brunner. Feasibility and Construct Validity of the Willingness-To-Pay (WTP) Technique for Measuring Health Care Preferences of Children with Juvenile Idiopathic Arthritis (JIA).Arthritis & Rheumatism 2004; 51: 899-908.