University of Cincinnati Department of Pediatrics

Jacob [Jack] J.H. Bleesing, MD, PhD

Appointment

Associate Professor of Pediatrics, University of Cincinnati College of Medicine

Email

jack.bleesing@cchmc.org

Phone

513-636-4266

Fax

513-636-3549

Credentials

MD: University of Leiden, Leiden, The Netherlands, 1989.
PhD: University of Leiden, Leiden, The Netherlands, 2002.
Residency: Pediatrics, University of Florida, Gainesville, Florida, 1993.
Fellowship: Allergy/Immunology, Duke University Medical Center, Durham, North Carolina, 1995.
Fellowship: Clinical Laboratory Immunology, National Institutes of Health, Bethesda, Maryland, 2001.

Research

Clinical Investigation of Primary Immunodeficiency Disorders, with emphasis on disorders of immunodysregulation and B-cell disorders
Immuno-reconstitution following blood and marrow transplantation
Diagnostic immunology, with emphasis on flow cytometry

Publications, Most Recent

Connect to Jack Bleesing's publications on PubMed

JJH Bleesing, TA Fleisher, JM Puck. Autoimmune lymphoproliferative syndrome (ALPS). In "Immunologic Disorders in Infants and Children", 5th edition. ER Stiehm, HD Ochs, JA Winkelstein (eds). WB Saunders, Philadelphia. 2004.

JJH Bleesing. Autoimmune lymphoproliferative syndrome (ALPS).Current Pharmaceutical Design. 9:265-278, 2003.

JJH Bleesing, JE Janik, TA Fleisher. Common expression of an unusual CD45 isoform from patients with large granular lymphocyte leukemia and autoimmune lymphoproliferative syndrome.Br J Haematol. 120:93-96, 2003.

JJH Bleesing, TA Fleisher. Human B cells express a CD45 isoform that is similar to murine B220 and is down-regulated upon acquisition of the memory B-cell marker CD27.Clin Cytometry. 51:1-8, 2003.

JJH Bleesing, MR Brown, C Novicio, D Guarraia, JK Dale, SE Straus, TA Fleisher. A composite picture of TcR-a/ß + CD4- CD8- T cells (a/ß -DNTCs) in humans with autoimmune lymphoproliferative syndrome.Clin Immunol. 104:21-30, 2002.

Presentations

Participated in the Cincinnati Children's Hospital Center for Immunological Research Retreat, July 2007. "Defects of Lymphocyte Homeostasis in Humans".

Invited Speaker Pediatric Grand Rounds (the Annual Rosalind Abernathy Lecture). Arkansas Children's Hospital, Little Rock, AR, May 2007. "Myth busters of the Immune System".

Invited Speaker at the 2007 BMT Tandem Meetings, February 2007. "Emerging Targets for HCT: Genetic Disorders of Hematopoiesis and Immunity. Autoimmune Lymphoproliferative Syndrome (ALPS)."

Invited Speaker at the B-cell Symposium, organized by the FOCIS Center of Excellence at CCHMC, CCHMC, Cincinnati, OH December 2006. "Monitoring B-cell Depletion Therapy".

Invited Faculty for the Update in Immunology Meeting, organized by the Pediatric Society of Argentina (Sociedad Argentina de Pediatria), Buenos Aires, Argentina, October 2006. "Autoimmune Cytopenias, a Matter of Immunologic Diplomacy".

Participated in the 2006 "Foundations in Immunology" lecture series, UC, Cincinnati, OH, March 2006. "Primary Immunodeficiency Disorders".

Invited Speaker at the Annual Meeting of the American Academy of Allergy, Asthma and Immunology, Miami Beach, Florida, March 2006. "X-linked Proliferative Disease".

Invited Faculty for the "Breakfast with the Professors" session during the Annual Meeting of the American Academy of Allergy, Asthma and Immunology, Miami Beach, Florida, March 2006.

Invited Speaker at the Combined Adult/Pediatric Rheumatology/Immunology Research-in-Progress series, CCHMC/UC, Cincinnati, OH, February 2006. "Update on ALPS".

Invited Reviews/Book Chapters, Most Recent

K Zhang, JA Johnson, J Biroschak, J Villanueva, S Lee, JJH Bleesing, RJ Wenstrup, AH Filipovich. The A91V substitution in the Perforin 1 (PRF1) gene is found in patients with Familial Hemophagocytic Lymphohistiocytosis (FHL) in combination with other PRF1 or Munc13-4 mutations. International Journal of Immunogenetics. 2007 (in press).

S Kahwash, B Fung, S Savelli, J Bleesing, S Qualman. Autoimmune Lymphoproliferative Syndrome (ALPS): A Case with Congenital Onset. Pediatr Dev Pathol. March 2007.

JJH Bleesing, A Prada, J Villanueva, D Siegel, J Olson, N Ilowite, H Brunner, T Griffin, TB Graham, DD Sherry, MH Passo, A Filipovich, AA Grom. The diagnostic significance of soluble CD164 and soluble IL2Ra chains in macrophage activation syndrome and untreated new onset systemic juvenile idiopathic arthritis. Arthritis Rheum. 56(3):965-971, 2007.

JJH Bleesing, MM Souto-Carneiro, WJ Savage, MR Brown, C Martinez, S Yavuz, S Brenner, RM Siegel, ME Horwitz, PE Lipsky, HL Malech, TA Fleisher. Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment. J. Immunol. 176:7096-7103, 2006.

JJH Bleesing. Sorting out the causes of ALPS. J. Pediatr. 147(5):571-574, 2005.

JJH Bleesing, TA Fleisher. Human B cells express a CD45 isoform that is similar to murine B220 and is down-regulated upon acquisition of the memory B-cell marker CD27. Clin Cytometry. 51:1-8, 2003.

JJH Bleesing, MR Brown, C Novicio, D Guarraia, JK Dale, SE Straus, TA Fleisher. A composite picture of TcR-alpha/beta+ CD4- CD8- T cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome. Clin Immunol. 104:21-30, 2002.

DM Frucht, M Gadina, GJ Jagadeesh, I Aksentijvach, K Takada, JJH Bleesing, J Nelson LM Muul G Perham, G Morgan, EJA Gerritsen, RF Schumacher, P Mella, PA Veys, TA Fleisher, ER Kaminski, LD Notarangelo, JJ O'Shea, F Candotti. Unexpected and variable phenotypes in a family with JAK3 deficiency. Genes and Immunity. 2:422-432, 2001.

JJH Bleesing, MR Morrow, G Uzel, TA Fleisher:.Human T cell activation induces the expression of a novel CD45 isoform that is analogous to murine B220 and is associated with altered O-glycan synthesis and onset of apoptosis. Cell Immunol. 213:72-81, 2001.

WJ Savage, JJH Bleesing, D Douek, MR Brown, GM Linton, HL Malech, ME Horwitz. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. Bone Marrow Transplantation. 28:463-472, 2001.

JJH Bleesing, MR Brown, SE Straus, JK Dale, RM Siegel, M Johnson, MJ Lenardo, JM Puck, TA Fleisher. Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome. Blood. 98:2466-247, 2001.

JJH Bleesing, MR Brown, JK Dale, SE Straus, MJ Lenardo, JM Puck, TP Atkinson, TA Fleisher. TcR-alpha/beta+ CD4- CD8- T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin Immunol. 100:314-324, 2001.

U Lopatin, X Yao, RK Williams, JJH Bleesing, JK Dale, D Wong, J Teruya-Feldstein, S Fritz, MR Morrow, I Fuss, MC Sneller, M Raffeld, TA Fleisher, JM Puck, W Strober, ES Jaffe, SE Straus. Increases in circulating and lymphoid tissue IL-10 in autoimmune lymphoproliferative syndrome (ALPS) are associated with disease expression. Blood. 97:3161-3170, 2001.

JJH Bleesing, KA Risma. Assessment of Functional Immune Responses. In "Clinical Immunology: Principles and practice", 3nd edition. TA Fleisher, BL Kotzin, RR Rich, HW Schroeder, WT Shearer (eds). Elsevier, London. 2007.

AH Filipovich, J Bleesing, F Goldman. Emerging targets for hematopoietic cell transplantation (HCT): Genetic disorders of hematopoiesis and immunity. Biol Blood Marrow Transplant. 13S1:58-63, 2007.

JJH Bleesing, Johnson J, Zhang K (September 2006) Autoimmune Lymphoproliferative Syndrome in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2006. Available at http://www.genetests.org

JJH Bleesing (Editor): First – Fourth editions of the Newsletter, published by the Diagnostic Immunology Laboratories, Division of Hematology/Oncology, CCHMC. Fall 2005 through Spring 2007 [http://www.cincinnatichildrens.org/immunodeficiencies/].

JJH Bleesing. Sorting out the causes of ALPS (editorial). Journal of Pediatrics. 147:571-574, 2005.

JJH Bleesing. Assays for B Cell and Germinal Center Development (unit 7.34) In "Current Protocols in Immunology". JE Coligan, BE Bierer, DH Margulies, EM Shevach, W Strober (eds.). John Wiley & Sons, Hoboken, 2004.

JJH Bleesing, TA Fleisher, JM Puck. Autoimmune lymphoproliferative syndrome (ALPS). In "Immunologic Disorders in Infants and Children", 5th edition. ER Stiehm, HD Ochs, JA Winkelstein (eds). WB Saunders, Philadelphia. 2004.

JJH Bleesing. Autoimmune lymphoproliferative syndrome (ALPS). Current Pharmaceutical Design. 9:265-278, 2003.

Abstracts and Letters, Most Recent

K Zhang, J Biroschak, J Bleesing, J Johnson, A Filipovich. Genetic Profiles of Munc13-4 gene in Patients with Familial Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. (abstract for the 2007 annual meeting of the American College of Medical Genetics, 2007).

EA Bailey, JJ Bleesing, SM Jones, TT Perry, UM Nagarajan, AM Scurlock. Major Histocompatibility Complex Class II deficiency in a child with panhypogammaglobulinemia and lymphopenia. (abstract for the 2007 annual meeting of the American Academy of Allergy, Asthma and Immunology, 2007).

MJ Gelfand, JJ Bleesing, NA Yazigi, LT Young, SE Sharp ML Cooper. FDG PET imaging in lymphoproliferative and selected histiocytic diseases. (abstract for the 50th annual meeting of the Society of Pediatric Radiology, 2006).

KA Risma, R Deering, L Monaco-Shawver, M Heltzer, J Burnham, J Niemal, TA Fleisher, JJ Bleesing, PE Putnam, A Jain, JS Orange. Ectodermal dysplasia with immunodeficiency and lymphedema, but not osteopetrosis, is associated with a unique NF-kB Essential Modulator (NEMO) mutation. (abstract for the Primary Immunedeficiency Consortium meeting, organized by the Clinical Immunology Society, 2005).

NS Longo, JJH Bleesing, JK Dale, TA Fleisher, SE Straus, PE Lipsky: Abnormal selection and B cell memory in human Fas deficiency. (abstract for the Experimental Biology (FASEB) meeting, 2004).