Jarek Meller, PhD
Title
Associate Professor
Appointment
Associate Professor of Pediatrics
Email
jmeller@cchmc.org
Phone
513-636-0270
Fax
513-636-2056
Research
To learn more about Jarek Meller, including his research projects and publications, and to use software tools he has helped to develop, visit the site of his research lab: http://folding.chmcc.org.
Research Grants and Contracts
Title: Optimization of Folding and Threading Potentials
Sponsor: National Institutes of Health
PI: Elber, R
Dates: 02/01/2004 - 01/31/2008
Title: Cincinnati DDRDC: Center for Growth and Development (CGD)
Sponsor: National Institutes of Health
PI: Cohen, M
Dates: 04/01/2003 - 03/31/2008
Title: Genomic Landscapes in Large Scale Integrated JRA Studies
Sponsor: National Institutes of Health
PI: Thompson, S
Dates: 09/15/2003 - 08/31/2007
Title: Optimization of Folding and Threading Potentials
Sponsor: National Institutes of Health
PI: Elber, R
Dates: 02/01/2004 - 01/31/2008
Title: Computational Medicine Center
Sponsor: Ohio BRTT Partnership Award
PI: Boat, T
Dates: 07/01/2004 - 06/30/2007
Title: Norwalk-like Viruses and their Receptors
Sponsor: National Institutes of Health
PI: Jiang, X
Dates: 07/01/2005 - 06/30/2010
Publications, Most Recent
Tan M, Xia M, Cao S, Huang P, Farkas T, Meller J, et al. Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study. Virology. 2008 Sep 30;379(2):324-34.
Olshavsky NA, Groh EM, Comstock CE, Morey LM, Wang Y, Revelo MP, et al. Cyclin D3 action in androgen receptor regulation and prostate cancer. Oncogene. 2008 May 15;27(22):3111-21.
Mikhaylova O, Ignacak ML, Barankiewicz TJ, Harbaugh SV, Yi Y, Maxwell PH, et al. The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Mol Cell Biol. 2008 Apr;28(8):2701-17.
Sinha AU, Meller J. Sensitivity analysis for reversal distance and breakpoint reuse in genome rearrangements. Pac Symp Biocomput. 2008:37-48.
Howarth JW, Meller J, Solaro RJ, Trewhella J, Rosevear PR. Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. J Mol Biol. 2007 Oct 26;373(3):706-22.
Porollo A, Meller J. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC bioinformatics. 2007;8:316.
Porollo A, Meller J. Prediction-based fingerprints of protein-protein interactions. Proteins. 2007 Feb 15;66(3):630-45.
Takatori A, Geh E, Chen L, Zhang L, Meller J, Xia Y. Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development. 2008 Jan;135(1):23-32.
Duch W, Swaminathan K, Meller J. Artificial intelligence approaches for rational drug design and discovery. Curr Pharm Des. 2007;13(14):1497-508.
Sinha AU, Meller J. Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms. BMC bioinformatics. 2007;8:82.
Cushion MT, Smulian AG, Slaven BE, Sesterhenn T, Arnold J, Staben C, et al. Transcriptome of Pneumocystis carinii during Fulminate Infection: Carbohydrate Metabolism and the Concept of a Compatible Parasite. PLoS ONE. 2007;2:e423.
Tan M, Meller J, Jiang X. C-terminal arginine cluster is essential for receptor binding of norovirus capsid protein. J Virol. 2006 Aug;80(15):7322-31.
Cao B, Porollo A, Adamczak R, Jarrell M, Meller J. Enhanced recognition of protein transmembrane domains with prediction-based structural profiles. Bioinformatics. 2006 Feb 1;22(3):303-9.
Slaven BE, Meller J, Porollo A, Sesterhenn T, Smulian AG, Cushion MT. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of eukaryotic microbiology. 2006;53 Suppl 1:S89-91.
Slaven BE, Porollo A, Sesterhenn T, Smulian AG, Cushion MT, Meller J. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of eukaryotic microbiology. 2006;53 Suppl 1:S151-3.
Ivanenkov VV, Meller J, Kirley TL. Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. Biochemistry. 2005 Jun 28;44(25):8998-9012.
Adamczak R, Porollo A, Meller J. Combining prediction of secondary structure and solvent accessibility in proteins. Proteins. 2005 May 15;59(3):467-75.
Wagner M, Adamczak R, Porollo A, Meller J. Linear regression models for solvent accessibility prediction in proteins. J Comput Biol. 2005 Apr;12(3):355-69.
Petre-Draviam CE, Williams EB, Burd CJ, Gladden A, Moghadam H, Meller J, et al. A central domain of cyclin D1 mediates nuclear receptor corepressor activity. Oncogene. 2005 Jan 13;24(3):431-44.
Porollo AA, Adamczak R, Meller J. POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins. Bioinformatics. 2004 Oct 12;20(15):2460-2.
Adamczak R, Porollo A, Meller J. Accurate prediction of solvent accessibility using neural networks-based regression. Proteins. 2004 Sep 1;56(4):753-67.
Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, Williams DA. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol. 2004 Jul;5(7):744-51.
Czyzyk-Krzeska MF, Meller J. von Hippel-Lindau tumor suppressor: not only HIF's executioner. Trends Mol Med. 2004 Apr;10(4):146-9.
Meller J. Advances in protein structure prediction: algorithms and applications. Warsaw; 2004.
Adamczak R, Meller J. On the transferability of folding and threading potentials and sequence-independent filters for protein folding simulations.. Mol Phys. 2004;102(11-12):1291-305.
Tan M, Huang P, Meller J, Zhong W, Farkas T, Jiang X. Mutations within the P2 domain of norovirus capsid affect binding to human histo-blood group antigens: evidence for a binding pocket. J Virol. 2003 Dec;77(23):12562-71.
Turowski M, Yamakawa N, Meller J, Kimata K, Ikegami T, Hosoya K, et al. Deuterium isotope effects on hydrophobic interactions: the importance of dispersion interactions in the hydrophobic phase. J Am Chem Soc. 2003 Nov 12;125(45):13836-49.
Kuznetsova AV, Meller J, Schnell PO, Nash JA, Ignacak ML, Sanchez Y, et al. von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2706-11.
Meller J, Malrieu JP, Heully JL. Size-consistent multireference CI through the dressing of the norm of determinants. Mol Phys. 2003;101(13):2029-41.
Meller J, Wagner M, Elber R. Maximum feasibility guideline in the design and analysis of protein folding potentials. J Comput Chem. 2002 Jan 15;23(1):111-8.
Meller J, Elber R. Protein recognition by sequence-to-structure fitness: bridging efficiency and capacity of threading models. In: Friesner RA, ed. Computational methods for protein folding: a special volume of advances in chemical physics. Indianapolis: Wiley & Sons 2002:77-130.
Meller J, Elber R. Linear programming optimization and a double statistical filter for protein threading protocols. Proteins. 2001 Nov 15;45(3):241-61.
Frary A, Nesbitt TC, Grandillo S, Knaap E, Cong B, Liu J, et al. fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. Science. 2000 Jul 7;289(5476):85-8.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
