Jeanne M. James, MD
Appointment
Research Assistant Professor
Credentials
MD: West Virginia University, Morgantown, WV, 1987.
Residency: Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 1987-90.
Fellowship: Pediatric Cardiology , Vanderbilt University Medical Center, Nashville, TN, 1991-94.
Certification: Pediatrics, 1990.
Recertified: Pediatrics, 1999-2005.
Certified: Pediatric Cardiology, 1996-2003.
Recertified: Pediatric Cardiology, 2004-2010.
Research
Jeanne M. James, MD, has a special interest in researching cardiac hypertrophy, ventricular remodeling and heart failure.
Research Grants and Contracts
Ohio Valley Affiliate, American Heart Association Beginning Grant-In-Aid "Investigation of Novel Heart Failure Therapy in Cardiomyopathic Rabbits"
Publications, Most Recent
James JM, Osinska H, Hewett TE, Kimball T, Klevitsky R, Witt S, Hall, DG, Gulick J, and Robbins J. (1999) Transgenic overexpression of a motor protein at high levels results in severe cardiac pathology. Transgenic Res 8:9-22.
James J, Sanbe A, Yager K, Martin L, Klevitsky H, and Robbins J. Genetic manipulation of the rabbit heart via transgenesis. (2000) Circulation 101:1715-21.
James J, Zhang Y, Osinska H, Sanbe A, Klevitsky R, Hewett TE, and Robbins J. Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy. (2000) Circ Res 87:805-811.
James J, Zhang Y, Wright K, Witt S, Glascock E, Osinska H, Klevitsky R, Martin L, Yager K, Sanbe A and Robbins J. Transgenic Rabbits Expressing Mutant Essential Light Chain Do Not Develop Hypertrophic Cardiomyopathy. (2002) J Mol Cell Cardiol 34:873-82.
Professional Organization Memberships
Special Interests
Jeanne M. James, MD, has a special interest in
molecular cardiology and
medical education.
Personal Statement
Research Description
As a pediatric cardiologist, I am interested in exploring the mechanisms that lead to altered heart function and the compensatory phenomena intrinsic to the myocardium.
Acquired heart disease of adulthood differs fundamentally from heart disease in infants and children, where alterations in cardiac pump function are frequently due to increased hemodynamic loads imposed by congenital cardiac malformations. While heart surgery is effectively curative in some congenital defects, in others surgery is a palliative procedure that leaves the patient with residual circulation abnormalities.
I study the progression of heart disease in mice and rabbits to understand the intermediate steps between cardiac compensation and overt heart failure. By defining the critical events in this cascade and determining where effective interventions can be made, the treatment of heart failure will hopefully be more successful, enabling children with residual cardiac dysfunction to enjoy more active lives.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
