University of Cincinnati Department of Pediatrics

Jens W. Goebel, MD

Title

Associate Professor of Pediatrics; Medical Director of Kidney Transplantation, Clinical Director of Nephrology and Hypertension

Appointment

Associate Professor of Pediatrics

Email

jens.goebel@cchmc.org

Phone

513-636-4531

Fax

513-636-7407

Bio

Dr. Goebel was recruited by Cincinnati Children's Hospital Medical Center in 2002 from the University of Kentucky to enhance the institution's kidney transplant program. His efforts along these lines focus both on further improving the clinical care of pediatric kidney transplant recipients and their families, as well as advancing basic and translational investigations into immunological aspects especially relevant to the field of transplantation.

Credentials

MD: University of Heidelberg (Germany), 1991.

Residency and Chief Residency: Deptartment of Pediatrics, University of South Alabama, Mobile, AL, 1991 to 1995.

Fellowship: Section of Pediatric Nephrology, Tulane University Medical Center, New Orleans, LA, 1995 to 1998.

Certifications: General Pediatrics, 1994, 2002; Pediatric Nephrology, 1999.

Awards and Honors

1987/8 Fulbright Travel Scholar
1988/9 Scholar of the German Academic Exchange Service
1993 Robert O. Harris III Award for outstanding performance as a resident, Department of Pediatrics, University of South Alabama
1995 NIH Young Investigator Travel Fellowship
1996 Oustanding House Officer Teaching Award (Fellow), Department of Pediatrics, Tulane University Medical Center
1997 Clinical Young Investigator Award, Southern Society for Pediatric Research
1998 Basic Science Young Investigator Award, Southern Society for Pediatric Research
1998/9 Young Investigator Awards, American Societies of Transplant Physicians and Transplantation as well as Transplantation Society
1999, 2002 Chairman's Research Award, Department of Pediatrics, University of Kentucky
2000-2 Director, Pediatric Hypertension Program, University of Kentucky
2003-8 Best Doctors in America
2008 America's Top Pediatricians

Research

Immunology

Research Grants and Contracts

Ongoing:

NIH RO1: CD40 Ligand Dyregulation and HIV Pathogenesis
(PI: Claire Chougnet, PhD, Division of Molecular Immunology, Cincinnati Children's Hospital)

NIH UO1: Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients (CTOT-01, Protocol Chair: Peter Heeger, MD, Mt. Sinai School of Medicine.

Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients
(PI: Sander Vinks, PhD; Pharm D, Pediatric Pharmacology Research Unit, Cincinnati Children's Hospital)

Cincinnati Children's Hospital Medical Center Translational Research Initiative:
Statin Therapy for Pediatric Kidney Transplant Recipients — Molecular Basis of Cardiovascular and Immunological Effects

Completed:
NIH KO8: The Cytoskeleton, Rafts and the Interleukin-2 Receptor

Roche Pharmaceuticals: Molecular Mechanisms of Immunomodulation Affected by Daclizumab in Kidney Transplant Recipients

National Kidney Foundation Young Investigator: Characterization of the Enrichment of the Interleukin-2 Receptor ß-Chain in Membrane Rafts of Human T-Cells
The Cytoskeleton, Rafts and the Interleukin-2 Receptor Molecular Mechanisms of Immunomodulation Affected by Daclizumab in Kidney Transplant Recipients Characterization of the Enrichment of the Interleukin-2 Receptor ß-Chain in Membrane Rafts of Human T-Cells

Co-Investigator:
NIH UO1 grant: Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients (CTOT-01, Protocol Chair: Peter Heeger, MD, Mt. Sinai Medical Center, New York City), commenced in late 2005 and ongoing

Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital, ongoing)

Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of Mycophenolic Acid in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital, ongoing)

Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid (PI: H. Brunner, Cincinnati Children’s Hospital, ongoing)

Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of IMPDH in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital, ongoing)

NIH RO1 grant: CD40 Ligand Dyregulation and HIV Pathogenesis (PI: Claire Chougnet, PhD, Division of Molecular Immunology, Cincinnati Children’s Hospital), 5 %, 01/01/05-12/31/07)

Publications, Most Recent

Forrest K, Logan B, Strange J, Roszman TL, Goebel J (2005) Daclizumab Therapy in Kidney Transplantation - Different Mechanisms of Action in- versus ex-vivo?Transplant Immunology 14 (1):43-7.

Goebel J, Forrest K, Jackson EC (2005) Anti-CD25 Antibody Therapy in Kidney Transplantation - Different Mechanisms of Action In- Versus Ex-Vivo?Transplant Immunol 14:43-7.

Mitsnefes MM, Subat-Dezulovic M, Khoury PR, Goebel J, Strife CF (2005) Increasing Incidence of Post Transplant Anemia in Children: Does It Affect Graft Survival?Am J Transplant 5:1713-8.

Goebel J, Logan B, Forrest K, Mieczkowski A, Roszman TL, Wills-Karp M (2005) Atorvastatin Attenuates Interleukin-2 (IL-2) Signaling by Altering the Lipid Raft Enrichment of the IL-2 Receptor β-Chain.J Invest Med 53:322-8.

Goebel J, Forrest K, Wills-Karp M, Roszman TL (2006) Tubulin Polymerization Modulates Interleukin-2 Receptor Signaling In T Cells.Journal of Receptors and Signal Transduction 26:87-106.

VanDeVoorde R, Witte D, Kogan J, Goebel J (2006) Pierson Syndrome - A Novel Cause of Congenital Nephrotic Syndrome.Pediatrics 118:e501-5.

Flynn JT, Nahata MC, Mahan Jr JD, Portman RJ, PATH-2 Investigators (2006) Population Pharmacokinetics of Amlodipine in Hypertensive Children and Adolescents.J Clin Pharmacol 46:905-16 (listed as local center PI in appendix).

Alam S, Goebel J, Pacheco MC, Sheldon C (2007) Papillary Urothelial Neoplasm of Low Malignant Potential in a Pediatric Renal Transplant Recipient: A Case Report.Pediatr Transplantation 11(6):680-2.

Dixon B, Goebel J (2007) Immunobiology of Pediatric Kidney Transplantation.Progress in Pediatric Urology 10: 165-82.

Laskin B, Goebel J (2008) Clinically Silent Weight Loss Associated With Mycophenolate Mofetil In Pediatric Renal Transplant Recipients.Pediatr Transplantation 12(1):113-6.

Kiessling S, Goebel J, Somers M (eds.): Pediatric Nephrology in the ICU.Springer Verlag (Heidelberg, Germany, 2008) .

Abraham EC, Wilson AC, Goebel J (2009) Current Kidney Allocation Rules and Their Impact on a Pediatric Transplant Center. Am J Transpl 9(2):404-8.

Nyakeriga AM, Fichtenbaum CJ, Goebel J, Nicolaou SA, Conforti L, Chougnet C (2009) Engagement of the CD4 receptor affects the redistribution of lck to the immunological synapse in primary T cells: implications for T cell activation during HIV-1 infection.J Virol 83(3):1193-200.

Prausa SE, Fukuda T, Maseck D, Curtsinger KL, Zhang K, Nick T, Liu C, Ellis E, Sherobtie J, Goebel J, Vinks A (in press, Clin Pharmacol Ther)Pharmacogenetics of Mycophenolate Mofetil Toxicity in Pediatric Kidney Transplant Recipients: A Pilot Study.

DeFoor W, Goebel J, Sheldon C (submitted to Current Opinions in Urology) Pediatric Kidney Transplantation.

Professional Organization Memberships

American Academy of Pediatrics
American Society of Nephrology
American Society of Pediatric Nephrology
American Society of Transplantation
International Pediatric Transplant Association
International Pediatric Nephrology Association
Society for Pediatric Research

Books

Dharamsi N, Sheldon C, Goebel J (2006) Kidney Transplantation. Chapter 25 in: The Kelalis-King-Belman Textbook of Clinical Pediatric Urology (Docimo SG, Canning DA, Khoury AE, editors), 5th edition, Taylor & Francis, London/NewYour/Philadelphia, pp. 367-85

Sheldon C, DeFoor W, Goebel J (submitted for the 2nd edition of Pediatric Urology, eds: Gearhart J, Rink R, Mouriquand P) Medical and Surgical Aspects of Kidney Transplantation.

Goebel J (in preparation for Pediatric Nephrology in the ICU, eds: Kiessling S, Goebel J, Somers M) PICU Management of Kidney Transplant Recipients.

Special Interests

Pediatric Kidney Transplantation, Transplantation Immunology, Renal Dysfunction in Children with other chronic conditions (non-renal transplants, other), and Pediatric Nephrology in the ICU.

Editorial Positions:

American editorial board, Clinical Nephrology

Kiessling S, Goebel J, Somers M (eds.): Pediatric Nephrology in the ICU, Springer Verlag (Heidelberg, Germany) - in preparation.

Presentations, Most Recent:

Chair of and presenter at the American Federation for Medical Research Translational Symposium "Lipid Rafts - Floating from Bench to Bedside" at the Experimental Biology/IUPS meeting, San Diego, 04/03/05

"Transplantation Immunology/Tolerance" lecturer, CCHMC immunobiology Graduate Program (2005)

Kathy Newman Lecturer with Pediatric Grand Round presentation ("Pediatric Kidney Transplantation - Come a Long Way or a Long Way To Go?") and case discussion at pediatric residents' lunch conference, Departments of Pediatrics, Tulane University and Ochsner Medical Center, New Orleans, LA, 02/28/07 - 03/01/07.

Co-organizer and chair of the symposium "Genetic Renal Disease 2: Lipid Rafts -- Floating from Bench to Bedside. Structure and function of the slit diaphragm. Mutational analysis" at the upcoming 2007 meeting of IPNA.

Co-organizer and chair of the ASPN-sponsored symposium "Pediatric Nephrology in Non-Kidney Organ Transplantation" at the upcoming 2007 ASPN Annual Meeting in conjunction with the Pediatric Academic Societies' Annual Meeting.