University of Cincinnati Department of Pediatrics

Jodie Duffy, PhD

Title

Co-Director Cardiothoracic Surgery Research Program

Appointment

Research Assistant Professor

Email

jodie.duffy@cchmc.org

Phone

513-636-8147

Fax

513-636-3847

Credentials

PhD: University of Missouri, Columbia, Missouri, 1995.

MS: The Ohio State University, Columbus, Ohio, 1992.

BS: The Ohio State University, Columbus, Ohio, 1990.

Awards and Honors

NIH Molecular Biology Trainee Grant
University of Missouri Delta Gamma Sigma National Honor Society
Phi Kappa Phi National Honor Society

Research Grants and Contracts

2004 - 2006 Co-investigator, National Institutes of Health, National Institute of Child Health and Human Development – 1 R03 HD046896-01 Alleviation of Reperfusion-Mediated Cardiac Dysfunction.

2003 – 2005 Principal Investigator, American Heart Association, Ohio Valley Affiliate – 0365284B
Calpain/calpastatin regulation of reoxygenation injury.

2002 – 2004 Co-investigator, American Heart Association, Ohio Valley Affiliate - 0255295B
Cardiopulmonary bypass-related myocardial injury In neonates.

2000 - 2002 Co-investigator, American Heart Association, Ohio Valley Affiliate - 0060317B
The role of nitric oxide in the regulation of ICAM-1 during myocardial hypoxia and reoxygenation.

2001 – 2002 Co-investigator, Children's Heart Foundation, Chicago, Illinois
The effects of methylprednisolone on the inflammatory response induced by cardiopulmonary bypass during repair of congenital heart disease.

Publications, Most Recent

J.Y. Duffy, G.J. Overmann, C.L. Keen, M.S. Clegg, G.P. Daston. 2004. Cardiac abnormalities induced by zinc deficiency are associated with alterations in the expression of genes regulated by the zinc-finger transcription factor GATA-4.Birth Defects Research, Developmental and Reproductive Toxicology 71:102-109.

J.M. Lyons, J.Y. Duffy, C.W. Wagner, J.M. Pearl. 2004. Effects of sildenafil citrate on cardiopulmonary function following hypoxia and reoxygenation with cardiopulmonary bypass.Journal of the American College of Surgeons (In press).

J.M. Lyons, J.Y. Duffy, J.M. Pearl. 2004. Compression of an extracardiac Fontan following classic Fontan revision.Journal of Cardiac Surgery (In press).

J.M. Pearl, S.M. Schwartz, D.P. Nelson, C.J. Wagner, J. M. Lyons, S.M. Bauer, J.Y. Duffy. 2004. Preoperative glucocorticoids decrease pulmonary hypertension in piglets after cardiopulmonary bypass and circulatory arrest.Annals of Thoracic Surgery 77:994-1000.

J. Y. Duffy, D.P. Nelson, S.M. Schwartz, C.J. Wagner, S.M. Bauer, J.M. Lyons, J.L. McNamara, J.M. Pearl. 2004. Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets.Pediatric Critical Care Medicine 5:28-34.

S.M. Schwartz, J.Y. Duffy, J.M. Pearl, S. Goins, C.J. Wagner, D.P. Nelson. 2003. Glucocorticoids preserve calpastatin and troponin I during cardiopulmonary bypass in immature pigs.Pediatric Research 54:91-97.

J.M. Pearl, D.P. Nelson, S.M. Schwartz, C.J. Wagner, S.M. Bauer, E.A. Setser, J.Y. Duffy. 2002. Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts. Annals of Thoracic Surgery 74:830-837.

J.M. Pearl, D.P. Nelson, J.L. Rakke, P.B. Manning, S.M. Schwartz, T.P. Shanley, H.R. Wong, J.Y. Duffy. 2002. Inhaled nitric oxide increases endothelin-1 levels: a potential cause of rebound pulmonary hypertension. Critical Care Medicine 30:89-93.

S.M. Schwartz, J.Y. Duffy, J.M. Pearl, D.P. Nelson. 2001. Cellular and molecular aspects of myocardial dysfunction.Critical Care Medicine 29:S214-219.

J.M. Pearl, D.P. Nelson, C.J. Wagner, J.P. Lombardi, J.Y. Duffy. 2001 Endothelin receptor blockade reduces ventricular dysfunction and injury after reoxygenation. Annals of Thoracic Surgery 72:565-570.

J.Y. Duffy, C.M. Miller, G.L. Rutschilling, G.M. Ridder, M.S. Clegg, C.L. Keen, G.P. Daston. 2001. A decrease in intracellular zinc precedes the detection of early indicators of apoptosis in HL-60 cells. Apoptosis 6:161-172.

Presentations, Most Recent:

J.Y. Duffy, J.M. Lyons, C.J. Wagner, J.P. Lombardi, J.M. Pearl. 2004. Calpain inhibition prevents both acute myocardial ischemia-reperfusion injury and apoptosis in neonatal piglets. Ohio Doctors Interested in Congenital Heart Defects Annual Meeting.

J.M. Lyons, J.Y. Duffy, J.H. Bell, C.J. Wagner, S.M. Schwartz, J.M. Pearl. 2003. Calpain inhibition ameliorates ischemia-reperfusion-induced cardiopulmonary dysfunction in neonates. American Academy of Pediatrics.

J.M. Lyons, J.Y. Duffy, C.J. Wagner, J.M. Pearl. 2003. Effects of sildenafil citrate on cardiopulmonary function following hypoxia and reoxygenation on cardiopulmonary bypass. Journal American College of Surgeons S24.

J.Y. Duffy, D.P. Nelson, S.M. Schwartz, J.M. Pearl. 2003. Perioperative glucocorticoids preserved myocardial function after cardiopulmonary bypass and deep hypothermic circulatory arrest in neonates. International Symposium on Myocardial Protection from Surgical Ischemic-Reperfusion Injury. Asheville, NC.

J.M. Pearl, S. M. Schwartz, D.P. Nelson, C.J. Wagner, J.P. Lombardi, J.Y. Duffy. 2002. Glucocorticoids suppress pulmonary hypertension after cardiopulmonary bypass by reducing endothelin and neutrophil adhesion molecules in neonatal lungs. American College of Cardiology.

J.M. Pearl, C.J. Wagner, J.L. McNamara, J.Y. Duffy. 2002. Superoxide dismutase reduces reoxygenation-induced cardiopulmonary dysfunction in immature hearts. American Academy of Pediatrics.