University of Cincinnati Department of Pediatrics

Kim M. Cecil, PhD

Title

Spectroscopist

Appointment

Research Associate Professor, Radiology, Pediatrics, Neuroscience

Email

kim.cecil@cchmc.org

Phone

513-636-8559

Fax

513-636-3754

Bio

Kim M. Cecil, PhD, received her BS degree from Kentucky Wesleyan College and her MS and PhD degrees from Vanderbilt University. After a post-doctoral fellowship in spectroscopy and MR imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Radiology Department and the Imaging Research Center at Cincinnati Children's Hospital Medical Center in 1998. She serves as a researcher and clinical MR spectroscopist.

In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked mental retardation disorder thought to be second only to fragile X in prevalence.

Credentials

BS: Chemistry & Mathematics, Kentucky Wesleyan College, 1988
MS: Chemistry, Vanderbilt University, 1991
PhD: Chemistry, Vanderbilt University, 1993
Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA

Awards and Honors

NIH Developmental Brain Disorders Study Section

Research

Dr. Cecil's research efforts focus on the application of MR spectroscopy and imaging in several populations by characterizing the features of inborn errors in metabolism and evaluating the effects of environmental neurotoxicants and radiation, respectively, on brain anatomy and function.

Research Grants and Contracts

R01 ES015559, Early Lead Exposure, ADHD and Persistent Criminality, 2007-2012, Co-Principal Investigator

P50 MH077138, Bipolar Disorder Imaging & Treatment Research Center, 2007-2012, Co-Investigator

R01 MH07043, Neurofunctional and Neurochemical Markers of Treatment Response in Early Onset Bipolar Mania, 2007-2012, Co-Investigator

R01 ES015689, Effects of Lead, Manganese and Stress During Development, 2006-2011, Co-Investigator

R01 CA112182, Neurobehavioral Late-Effects in Pediatric Brain Tumors, 2005-2010, Co-Investigator

R21 ES013524, Neurobehavioral Effects of Low-Level Manganese Exposure, 2005-2006, Co-Principal Investigator

R01 NS049172, Creatine Transport Across the Blood-Brain Barrier, 2004-2007, Co-Investigator

P01 ES011261, EPA R82938901, MR Assessment of Brain Function Altered by Lead Exposure, 2001-2006, Principal Investigator

Publications, Most Recent

Yuan, W., Holland, S.K., Schmithorst, V.J., Walz, N.C., Cecil, K.M., Jones, B.V., Karunanayaka, P., Michaud, L. and Wade, S.L. Diffusion Tensor MRI Reveals Persistent White Matter Alteration after Traumatic Brain Injury Experienced During Early Childhood. Am J Neuroradiol 2007, in press.

Cecil, K.M. MR spectroscopy of metabolic disorders. Neuroimaging Clin N Am, 2006; 16:87-116.

DelBello, M.P., Cecil, K.M., Adler, C.M., Strakowski, S.M. Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study. Neuropsychopharmacology, 2006; 31:1264-1273.

Cecil, K.M., Patel, N.C., DelBello, M.P. Inositol metabolism in pediatric bipolar disorders. Int J Clin Neuropsych, 2006; 3:177-183.

Yuan, W., Holland, S.K., Cecil, K.M., Dietrich, K.N., Wessel, S.D., Altaye, M., Hornung, R.W., Ris, M.D., Egelhoff, J.C., Lanphear, B.P. The Impact of Early Childhood Lead Exposure on Brain Organization. An fMRI Study of Language Function. Pediatrics, 2006; 118: 971-977.

Patel, N.C., DelBello, M.P., Cecil, K.M., Adler, C.M., Bryan, H.S., Stanford, K.E., Strakowski, S.M. Lithium treatment effects on myo-inositol in adolescents with bipolar depression. Biol Psychiatry, 2006; 60:998-1004.

Dinopoulos, A., Gorospe, J.R., Egelhoff, J.C., Cecil, K.M., Nicolaidou, P., Morehart, P., deGrauw, T. Discrepancy between neuroimaging findings and clinical phenotype in Alexander disease. Am J Neuroradiol, 2006; 27: 2088-2092.

Cecil, K.M., Kos, R.S. MRS and metabolic imaging in white matter diseases and pediatric disorders. Top Magn Res Imag, 2006; 17:275-293.

Ris, M.D., Ryan, P.M., Lamba, M., Brenemen, J., Cecil, K., Succop, P., Ball, W. An improved methodology for modeling neurobehavioral late-effects of radiotherapy in pediatric brain tumors. Pediatr Blood Cancer, 2005; 44:487-493.

Newmeyer, A., Cecil, K.M., Schapiro, M., Clark, J.F., Degrauw, T.J. Incidence of brain creatine transporter deficiency in males with developmental delay referred for magnetic resonance imaging. J Dev Behav Pediatr, 2005; 26:276-282.

Makoroff, K.L., Cecil, K.M., Care, M., Ball, W.S. Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. Pediatr Radiol, 2005; 35:668-676.

Dinopoulos, A., Cecil, K.M., Schapiro, M.B., Papadimitriou, A., Hadjigeorgiou, G.M., Wong, B., deGrauw, T., Egelhoff, J.C. Brain MRI and proton MRS findings in infants and children with respiratory chain defects. Neuropediatrics, 2005; 36:290-301.

Pyne-Geithman, G.J., deGrauw, T.J., Cecil, K.M., Chuck, G., Lyons, M.A., Ishida, Y., Clark, J.F. Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study. Mol Cell Biochem, 2004; 262:35-39.

Schapiro, M., Cecil, K.M., Doescher, J., Kiefer, A.M., Jones, B.V. MR imaging and spectroscopy in juvenile Huntington disease. Pediatr Radiol, 2004; 34:640-643.