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University of Cincinnati Department of Pediatrics

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Nives Zimmermann, M.D. is a member of the faculty and staff of Childrens Hospital Medical Center, Cincinnati involved in Pulmonary Medicine, Allergy, Clinical Immunology.

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Nives Zimmermann, MD

Title

Associate Professor of Pediatrics

Appointment

Associate Professor

Email

zimmn0@cchmc.org

Phone

513-636-3887

Fax

513-636-3310

Credentials

MD: School of Medicine, University of Zagreb; Zagreb, Croatia, 1995.

Position History

  • 1990-93 Teaching Assistant, Department of Biology, School of Medicine, Zagreb, Croatia
  • 1991-92 Researcher, Dept of Physiology & Immunology, School of Medicine, Zagreb, Croatia
  • 1992 Researcher, Department of Biology, School of Medicine, Zagreb, Croatia
  • 1992 Fellow, Institute for Molecular Biology, Salzburg, Austria
  • 1993-94 Researcher, Laboratory of Molecular Neuropharmacology, Department of Pharmacology, School of Medicine, Zagreb, Croatia
  • 1994 Karyn Kupcinet International Science School, Summer Program. Weizmann Institute of Science, Rehovot, Israel
  • 1995-96 Research Scholar, Dept of Otolaryngology-Head and Neck Surgery, U.Cincinnati College of Medicine, Cincinnati, Ohio
  • 1997-99 Research Associate, Division of Pulmonary Medicine, Allergy and Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio
  • 1999-2002 Instructor in Pediatrics, Children's Hospital Medical Center, U. Cincinnati College of Medicine, Cincinnati, Ohio
  • 2002-2008 Assistant Professor of Pediatrics, University of Cincinnati College of Medicine, Children’s Hospital Medical Center
  • 2005-present Member, Immunobiology Graduate Program, University of Cincinnati College of Medicine, Children’s Hospital Medical Center
  • 2008-present Associate Professor of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center

Awards and Honors

  • 1991-92 Dean's Award, School of Medicine, University of Zagreb, Zagreb, Croatia
  • 1991-94 University of Zagreb scholarship (awarded twice)
  • 1992 Scholarship awarded by the Republic of Austria; Institute of Molecular Biology, Salzburg, Austria
  • 1994 Summer student program of the Karyn Kupcinet International Science School, Rehovot, Israel
  • 1999 Symposia Funded Scholarship, Keystone Symposia
  • 1999 Travel Grant Recipient, American Academy of Allergy, Asthma & Immunology
  • 2004 Woman physician in allergy junior faculty development award (special recognition), AAAAI/Aventis

Research

Asthma; eosinophils; lung inflammation

Research Grants and Contracts

Dana Foundation (Bochner, Bruce), "Novel genetic and therapeutic approaches focusing on Siglec-8 for the diagnosis and treatment of human idiopathic eosinophilic disorders" October 1, 2007- September 30, 2010, Co-Investigator.

NIH / NIAID “Role of Acidic Environment in Eosinophilic Inflammation”, February 15, 2009 - January 31, 2011, Principal Investigator

Publications, Most Recent

Pope SM, Fulkerson PC, Blanchard C, Saito Akei H, Nikolaidis NM, Zimmermann N, Molkentin JD and Rothenberg ME. Identification of a cooperative mechanism involving IL-13 and eotaxin-2 in experimental allergic lung disease.J Biol Chem. 2005; 280(14):13952-61.

Zimmermann N, Doepker, MP, Witte DP, Stringer KF, Fulkerson PC, Pope SM, Brandt EB, Mishra A, King NE, Nikolaidis NM, Wills-Karp M, Finkelman FD, and Rothenberg ME. Expression and regulation of small proline rich protein (SPRR)2 in allergic inflammation.J Respir Cell Mol Biol 2005; 32(5):428-35.

Zimmermann N, Colyer JL, Koch L and Rothenberg ME. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1.BMC Immunol 2005; 6:7.

Pope SM, Zimmermann N, Stringer KF, Karow ML, Rothenberg ME. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia.J Immunol. 2005; 175(8):5341-50.

Fulkerson PC, Zhu H, Williams DA, Zimmermann N, Rothenberg ME. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.Blood. 2005; 106(2):436-43.

Brandt EB, Zimmermann N, Muntel EE, Yamada Y, Pope SM, Mishra A, Hogan SP, Rothenberg ME. The alpha4beta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.Clin Exp Allergy. 2006; 36(4):543-53.

Zimmermann N, Rothenberg ME. The arginine-arginase balance in asthma and lung inflammation.Eur J Pharmacol. 2006; 533(1-3):253-62

Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG and Zimmermann N. The cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.Proc Natl Acad Sci USA 2006; 103:14895

Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmermann N, Mahalingam S, Webb DC, Tremethick DJ, Thompson PJ, Hogan SP, Rothenberg ME, Cowden WB, Foster PS. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.J Immunol. 2006;177:5595-603.

Bergeron C, Boulet LP, Page N, Laviolette M, Zimmermann N, Rothenberg ME, Hamid Q. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.J Allergy Clin Immunol 2007;119:391-7.

Guo JP, Nutku E, Yokoi H, Schnaar RL, Zimmermann N, Bochner BS. Siglec-8 and Siglec-F: inhibitory receptors on eosinophils, basophils and mast cells.Allergy Clin Immunol Inter – J World Allergy Org 2007;19:54-59.

Zimmermann N. McBride M.L. Yamada Y. Hudson S.A. Jones C. Cromie K.D. Crocker P.R. Rothenberg M.E. Bochner B.S. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy 2008;63:1156-63.

Niese KA, Collier AR, Hajek AR, Cederbaum SD, O'Brien WE, Wills-Karp M, Rothenberg ME and Zimmermann N. Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC Immunology 2009, 10:33. PMCID: PMC2697973

Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey G, Rothenberg ME, Zimmermann N. Eosinophil viability is increased by acidic pH in a cAMP and GPR65-dependent manner. Blood. 2009; 114(13):2774-82

Presentations, Most Recent

The Role of Arginine Metabolism by NOS and Arginase in Allergic Airway Inflammation. American Academy of Allergy, Asthma and Immunology annual meeting; San Antonio, Texas, 2005.

The Role of Chemokines and Adhesion Molecules in Allergic Inflammation. AAAAI annual meeting; San Antonio, Texas, 2005.

Arginase and Arginine in Lung Inflammation. Immunology Council Seminar Series; Johns Hopkins Medicine, Baltimore, Maryland, 2006.

Inhibitory Receptors on eosinophils and Mast Cells. AAAAI annual meeting; Miami Beach, Florida, 2006.

All Things in Moderation: control of Allergic Inflammation. AAAAI annual meeting; Miami Beach, Florida, 2006.

Amino acids in immune regulation. AAAAI annual meeting; Miami Beach, Florida, 2006.

Professional Organization Memberships

  • Member, American Academy of Allergy, Asthma and Immunology
  • Member, American Association of Immunologists

Special Interests

Asthma; allergy

Committees

2001-present Women's Faculty Association – Web-site Committee, Chair, Cincinnati Children’s Hospital

2006-present Education council of Allergy/Immunology training program, Chair, Cincinnati Children’s Hospital

National Committees

2001-Present Cells and Cytokines Committee, American Academy of Allergy, Asthma and Immunology

2005-2007 Symposia Subcommittee of the Annual Meeting Program Committee (MAAI interest section vice-representative), American Academy of Allergy, Asthma and Immunology

2007-2009 Symposia Subcommittee of the Annual Meeting Program Committee (MAAI interest section representative), American Academy of Allergy, Asthma and Immunology

2005-2009 Women’s Involvement in the AAAAI Committee; Chair of the Sub-committee on involvement

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: