University of Cincinnati Department of Pediatrics

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Ralph A. Gruppo, MD

Title

Director, Comprehensive Hemophilia and Thrombosis Center; Director, Research Coagulation Laboratory

Appointment

Professor of Clinical Pediatrics, University of Cincinnati College of Medicine

Email

ralph.gruppo@cchmc.org

Phone

513-636-4269

Fax

513-636-5845

Credentials

MD: Johns Hopkins Medical School, Baltimore, MD, 1967

Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio; Johns Hopkins School of Medicine, Baltimore, MD, 1970

Fellowship: Pediatric Hematology/ Oncology, Children's Hospital Medical Center, Cincinnati, OH, 1974

Certification: Pediatrics, 1975; Pediatric Hematology/Oncology, 1976.

Awards and Honors

• Junior Faculty Clinical Fellow, American Cancer Society (1973 - 1976)
• Alpha Nu Alpha (Jesuit National Honor Society)
• American Society of Pediatric Hematology/Oncology Editorial Board
• Board Member, Hemophilia Research Society of North America, Board of Directors (1996 - present)
• FamOhio Ira Gaffin Memorial Award for Hemophilia (1997)
• Best Doctors in America, 2008

Publications, Most Recent

Connect to Ralph Gruppo's publications on PubMed

Gelfand MJ, Gruppo RA, Nasser MP. Ventilation-perfusion scintigraphy in children and adolescents is associated with a low rate of indeterminate studies. Clinical Nuclear Medicine 2008;33:606-609.

Wu SW, Graham B, Gelfand MJ, Gruppo RA, Dinopolous A, Gilbert DL. Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome.Mov Disord 2007;22:1813-1815.

Morris TA, Marsh JJ, Chiles PG, Kim NH, Noskovack KJ, Magana MM, Gruppo RA, Woods VL, Jr. Abnormally sialylated fibrinogen -chains in a patient with chronic thromboembolic pulmonary hypertension.Thromb Res 2007;119:257-259.

Chan, E.L., Harris R.E., Emery, K.H., Gelfand, M.J., Collins, M.H., Gruppo, R.A. Favorable histology, MYCN-amplified 4S neonatal neuroblastoma.Pediatr Blood Cancer, Published Online December 6, 2005.

Tamary, H., Dgany, O., Proust, A., Krasnov, T., Avidan, N., Eidelitz-Markus, T., Tchernia, G., Genevieve, D., Cormier-Daire, V., Bader-Meunier, B., Ferrero-Vacher, C., Munzer, M., Gruppo, R.A., Fibach, E., Konen, O., Yaniv, I., Delaunay, J. Clinical and molecular variablility in congenital dyserythropoeitic anaemia type I.British Journal of Haematology, 130: 628-634, 2005.

Liu, J., Jackson, C.W., Gruppo, R.A., Jennings, L.K., Gartner, T.K. The β3 subunit of the integrin αІІbβ3 regulates αІІb-mediated outside-in signaling. Blood, 105: 4345-4352, 2005.

Balasa, V.V., Gruppo, R.A., Glueck, C.J., Wang, P., Roy D.R., Wall, E.J., Mehlman, C.T., Crawford, A.H. Legg-Calve-Perthes disease and thrombophilia.J Bone Joint Surg Am, 86-A:2642-7, 2004.

Gruppo, R.A., Brown, D., Wilkes, M.M., Navickis, R.J. Meta-analytic evidence of increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII. Haemophilia, 10:747-50, 2004.

Tarantino, M.D., Collins, P.W., Hay, C.R.M., Shapiro, A.D., Gruppo, R.A., Berntorp, E., Bray, G.L., Tonetta, S.A., Schroth, PC., Retzios, A.D., Rogy, S.S., Sensel, M.G., Ewenstein, B.M., and the RAHF-PFM Clinical Study Group. Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A. Haemophilia, 10:428-437, 2004.

Gruppo, R.A., Brown, D., Wilkes, M.M., and Navickis, R.J. Increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII – a robust meta-analytic finding.Haemophilia, 10:449-451, 2004.

Morrison, J.A., Gruppo, R.A., Glueck, C.J., Stroop, D., Fontaine, R.N., Wang, P., Smyth, K. Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with race but not with insulin resistance in black and white children. Metabolism, 53:465, 2004.

Abstracts

Balasa VV, Kim M, Gruppo RA. Thrombophilic Polymorphisms in Pediatric Catheter-related Versus Non Catheter-related Venous Thromboembolism. International Society of Hemostasis and Thrombosis, July 2007.

Gruppo RA, Davies S, Balasa VV. Increased Age-related Expression of FVIII In Two Unrelated Females With Severe Hemophilia A and Nonrandom X-inactivation. International Society of Hemostasis and Thrombosis, July 2007.

Morris TA, Magana M, Marsh JJ, Chiles PG, DiSantis D, Gruppo RA, Woods VL. Heterozygous Fibrinogen γ-375 arg_trp Mutation Associated with Excessive Disialylation, Plasmin Resistance and Chronic Thromboembolic Pulmonary Hypertension. International Society of Hemostasis and Thrombosis, July 2007.

Gelfand, Michael J.; Gruppo Ralph A. Ventilation Perfusion Scintigraphy in Children and Adolescents is Associated with a Low Rate of Indeterminate Studies. Society of Nuclear Medicine, 2006.

Negrier C, Shapiro A, Berntorp E, Pabinger I, Tarantino M, Gruppo R, Scharrer I, Retzios A, Fritsch S, Patrone L, Luu H, Ewenstein B Clinical Efficacy and Safety of ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (rAHF-PFM) for Peroperative Management of Hemostasis. World Federation of Hemophilia, 2006.

Gruppo R, Collins P, Shapiro A, Hay C, Tarantino M, Retzios A, Schroth P, Aug C, Spotts G, and Ewenstein B for the rAHF-PFM Clinical Study Group Long-term Clinical Evaluation of Safety, Efficacy and Immunogenicity of rFVIII Plasma/Albumin Free Method (rAHF-PFM) in Previously Treated Hemophilia A Patients – Final Report. World Federation of Hemophilia, 2006.

Shapiro A, Abshire T, Hernandez F, Gruppo R, Tarantino M, Warrier I, Schroth P, Spotts G, Ewenstein E Efficacy and Safety of ADVATE rAHF-PFM for Perioperative Management of Hemostasis in Previously Treated Children with Hemophilia A. World Federation of Hemophilia, 2006.

Liu, J., Jackson, C.W., Gruppo R.A., Jennings, L.K., Gartner, T.K. The β3 Subunit of the IntegrinαIIbβ3 Regulates IIbβ-Mediated Outside-In Signaling. American Society of Hematology, 2004 published in Blood 104: 104:62b, 2004.

Professional Organization Memberships

• American Academy of Pediatrics
• American Academy of Pediatrics/Ohio Chapter
• American Association for the Advancement of Science
• American Society of Clinical Oncology
• American Society of Hematology
• American Society of Internal Medicine
• American Society of Pediatric Hematology/Oncology
• Cincinnati Pediatric Society
• Hemophilia and Thrombosis Research Society
• International Society of Thrombosis and Hemostasis
• Midwest Foundation for Medical Care
• National Hemophilia Foundation (local chapter)
• World Federation of Hemophilia
• Academy of Clinical and Applied Thrombosis/Hemostasis
  

Abstracts

Liu, J., Jackson, C.W., Gruppo R.A., Jennings, L.K., Gartner, T.K. The β3 Subunit of the IntegrinαIIbβ3 Regulates IIbβ-Mediated Outside-In Signaling. American Society of Hematology, 2004 published in Blood 104: 104:62b, 2004.

Musselman, M.S., Jacobs, B., Brilli, R., Becker, A., Gruppo, R.A. Increased Tissue Factor and Tissue Factor Pathway Inhibitor Is Associated with Extensive Cutaneous Thrombosis in Children with Sepsis Associated Purpura Fulminans. American Society Hematology, 2003.

Balasa, V,.V., Gruppo, R.A., Pillow, A.G., Becker, A., Stroop, D., Glueck, C.J. Legg-Perthes disease and thrombophilia: A causal association? International Society of Hemostasis and Thrombosis, 2003.

Friedman, K.D., Gruppo, R.A., Ebert, D.D., Kakela, J.K., Bellissimo, D.B., Endres, J.L., Montgomery, R.R. International Society of Hemostasis and Thrombosis, 2003.

Shapiro, A., Collins, P., Tarantino, M., Gruppo, R.A., Hay, C., Berntorp, E., Retzios, A., Sensel, M., Tonetta, S. B Ewenstein for the r-AHF-PFM Clinical Study Group. International Society of Hemostasis and Thrombosis, 2003.

Gruppo, R.A., Brown, D., Wilkes, M.M., Navickis, R.J. Comparative effectiveness of full-length and B-Domain deleted factor VIII for prophylaxis – a meta-analysis. International Society of Hemostasis and Thrombosis, 2003.

Special Interests