University of Cincinnati Department of Pediatrics

Robert Bruce Hinton, Jr., MD

Appointment

Assistant Professor, University of Cincinnati College of Medicine

Email

robert.hinton@cchmc.org

Phone

513-636-0389

Fax

513-636-5958

Credentials

BA: Bucknell University, Lewisburg, PA (Art History)

MD: Medical University of South Carolina, Charleston, SC

Residency: Pediatrics, Memorial Health University Medical Center, Savannah, GA

Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Fellowship: Cardiovascular Genetics, Cincinnati Children's Research Foundation, Cincinnati, OH

Certification: Pediatrics, Pediatric Cardiology

Awards and Honors

Alpha Omega Alpha
NIH Department Training Grant (T32 HD43005, PI Thomas F. Boat, MD), 2004-2006
NIH Loan Repayment Program (Pediatric Research), 2004; Renewal, 2006
Young Investigator Award, American Academy of Pediatrics, 2005
Young Investigator Travel Award, American Society of Matrix Biology, 2006
Young Investigator Travel Award, American Society for Clinical Investigation, 2007
Richard D. Rowe Award in Perinatal Cardiology, Society for Pediatric Research, 2007

Research

Cardiovascular genetics and cardiac development

Research Grants and Contracts

NIH K23 HL085122
"Genetic and Developmental Basis of Pediatric Aortic Valve Disease Pathogenesis"
Principal Investigator

Cincinnati Children's Research Foundation Trustee Award
"Genetic Basis of Pediatric Heart Disease"
Principal Investigator

NIH UO1 HL085057 Pediatric Heart Network (PI Benson)
"Trial of Beta Blocker Therapy (Atenolol) vs Angiotensin II Receptor Blocker Therapy (Losartan) in Individuals with Marfan Syndrome"
Co-Investigator

Publications, Most Recent

Hinton RB, Martin LJ, Rame-Gowda SR, Tabangin ME, Cripe LH, Benson DW. Hypoplastic Left Heart Syndrome Links to Chromosomes 10q and 6q and is Genetically Related to Bicuspid Aortic Valve. Journal of the American College of Cardiology. 2008; In press.

Hinton RB, Andelfinger G, Sekar P, Hinton AC, Gendron RL, Michelfelder EC, Robitaille Y, Benson DW. Prenatal Head Growth and White Matter Injury in Hypoplastic Left Heart Syndrome.Pediatric Research. 2008;64(4):364-369.

Hor KN, Border WL, Cripe LH, Benson DW, Hinton RB. The Presence of Bicuspid Aortic Valve Does Not Predict Ventricular Septal Defect Type. American Journal of Medical Genetics. 2008;146A(24):3202-3205.

Levay AK, Peacock JD, Lu Y, Koch M, Hinton RB, Kadler KE, Lincoln J. Scleraxis is Required for Cell Lineage Differentiation and Extracellular Matrix Remodeling during Murine Heart Valve Formation in Vivo. Circulation Research. 2008;103(9):948-956.

Hinton RB, Alfieri C, Witt S, Glascock B, Khoury PR, Benson DW, Yutzey KE. Mouse Heart Valve Structure and Function: Echocardiographic and Morphometric Analyses from the Fetus through the Aged Adult. American Journal of Physiology – Heart and Circulatory Physiology. 2008;294(6):H2480-2488.

Hinton RB. Family History: Reemergence of an Established Tool. Critical Care Nursing Clinics of North America. 2008;20(2):149-158.

Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram D, Menick D, Field LJ, Firulli AB, Molkentin JD, Markwald RR, Conway SJ. Periostin is Required for Maturation and ECM Stabilization of the Heart’s Non-Cardiomyocyte Lineages. Circulation Research. 2008;102(7):752-760.

Hinton RB. Pediatric Cardiology and the Research Mission. American Heart Association Cardiovascular Disease in the Young Council Newsletter. 2008;6(Spring):17-18.

Hinton RB, Martin LJ, Tabangin ME, Mazwi ML, Cripe LH, Benson DW. Hypoplastic Left Heart Syndrome is Heritable. Journal of the American College of Cardiology. 2007;50:1590-1595.

Sutherell J, Zarate Y, Tinkle BT, Markham LW, Cripe LH, Hyland JC, Witte D, Hopkin RJ, Hinton RB. Novel Fibrillin 1 Mutation in a Case of Neonatal Marfan Syndrome: the Increasing Importance of Early Recognition. Congenital Heart Disease. 2007;2:342-346.

Zhao B, Etter L, Hinton RB, Benson DW. BMP and FGF Regulatory Pathways in Semilunar Valve Precursor Cells.Developmental Dynamics. 2007;236(4):971-980.

Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddechi M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and 13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations. Human Genetics. 2007;121(2):275-284.

Hinton RB, Lincoln J, Deutsch GH, Osinska H, Manning PB, Benson DW, Yutzey KE. Extracellular Matrix Remodelling and Organization in Developing and Diseased Aortic Valves.Circulation Research. 2006;98:1431-1438.

Hinton RB, Deutsch GH, Pearl JM, Hobart HH, Morris CA, Benson DW. Bilateral Semilunar Valve Disease in a Child with Partial Deletion of the Williams-Beuren Syndrome Region is Associated with Elastin Haploinsufficiency. Journal of Heart Valve Disease. 2006;15:352-355.

Hinton RB, Michelfelder EC. Reverse Orientation of the Ductus Arteriosus in Neonates with Pulmonary Outflow Tract Obstruction is Associated with the Need for Early Intervention. American Journal of Cardiology. 2006;97(5):716-719.