Daniel Nebert, MD
Appointment
Professor
Credentials
BA: Wesleyan University, Middletown, Connecticut, 1956-59, Biology, Chemistry
MS: University of Oregon Medical School, Portland, 1961-64, Biochemistry
MD: University of Oregon Medicine School, Portland, 1959-64, Medicine
Awards and Honors
- 2001 Keynote Speaker, Penn State Univ Life Sci Consortium's Colloq, Penn State Sch of Med, Hershey, PA
- 2001 Plenary Lecture, Annu Mtg of the Joint Chinese-Australian Pathologists, Hong Kong Acad of Medicine, China
- 2002 Keynote Speaker, Plenary Session "Human Genome: the Aftermath and the Future," 11th Meeting of the North American International Society for the Study of Xenobiotics (ISSX), Orlando, Florida
- 2005 Winner of the Society of Toxicology's Distinguished Lifetime Toxicology Scholar Award, presented during Annual SOT Meeting, New Orleans, Louisiana
Research
The research program of Dr. Nebert studies the diversity, specificity and evolution of metabolism-gene, receptor-gene and transporter-gene superfamilies, and their roles in metabolism of endogenous regulators of homeostasis as well as foreign chemicals. Additional directions of research include the genetics of oxidative stress, programmed cell death (apoptosis), heavy metal toxicity, human & mouse gene nomenclature, pharmacogenetics, and clinical pharmacogenomics. The main theme being addressed by his laboratory has always been: Given the same dose of a particular drug or environmental agent, why do individual mice (or humans) respond differently in developing toxicity or cancer?
Publications, Most Recent
Selected Peer-Reviewed Publications (from total of more than 530)
Dalton TP, Dieter MZ, Matlib RS, Childs N, Shertzer HG, Genter MB, Nebert DW. Targeted knockout in the Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.Biochem Biophys Res Commun 2000; 267: 184–189
Nebert DW, Roe AL, Dieter MZ, Solis WA, Yang Y, Dalton TP. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis.Biochem Pharmacol 2000; 59: 65–85
Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW. Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.Biohem Biophys Res Commun 2000; 279: 324–329
Nebert DW. "Extreme discordant phenotype" methodology: an intuitive approach to clinical pharmacogenetics.Eur J Pharmacol 2000; 410: 107–120
Smith AG, Clothier B, Carthew P, Childs NL, Sinclair PR, Nebert DW, Dalton TP. Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.Toxicol Appl Pharmacol 2001; 173: 89–98
Su ZG, Zhang SZ, Hou YP, Li T, Nebert DW, Zhang L, Huang DJ, Liao LC, Xiao CY. Single-nucleotide polymor-phisms in the lipoprotein lipase (LPL) gene associated with coronary heart disease in Chinese.Eur J Pharmacol 2002; 454: 9–18
Nebert DW, Russell DW. Clinical importance of the cytochromes P450.Lancet 2002; 360: 1155–1162
Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP. Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse: novel model system for a severely compromised oxidative stress response.J Biol Chem 2002; 297: 49446–49452
Smith AG, Davies R, Dalton TP, Miller ML, Judah D, Riley J, Gant T, Nebert DW. Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.EHP Toxicogenomics 2003; 111: 855–861
Tsuneoka Y, Dalton TP, Miller ML, Clay CD, Shertzer HG, Talaska G, Medvedovic M, Nebert DW. 4-Aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. J Natl Cancer Inst 2003; 95: 1227–1237
Dieter MZ, Freshwater SL, Miller ML, Shertzer HG, Dalton TP, Nebert DW. Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress.Free Radic Biol Med 2003; 35: 351–367
Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW. Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.Mol Pharmacol 2004; 65: 1225–1237
Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.J Biol Chem 2004; 279: 23847–23850
Nebert DW, Vesell ES. Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead.Eur J Pharmacol 2004; 500: 267–280
Jiang ZW, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW. Toward the evaluation of function in genetic variability: characterizing human SNPs and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.Hum Mutat 2005; 25: 196–206
Dalton TP, He L, Wang B, Miller ML, Jin L, Stringer KF, Chang XQ, Baxter GS, Nebert DW. Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis.Proc Natl Acad Sci USA 2005; in press
