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Clinical Pharmacology

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Tsuyoshi Fukuda, PhD

Title

Clinical Pharmacology

Appointment

Research Associate Professor, University of Cincinnati College of Medicine

Email

tsuyoshi.fukuda@cchmc.org

Phone

513-803-0428

Fax

513-636-0168

Bio

Dr. Fukuda received his Pharmacy degree and Ph.D. in Pharmaceutical Science from Osaka University, Japan. He received postdoctoral training in the department of Clinical Pharmacology and Pharmacogenomics (Prof. J. Azuma, MD) and served as an Assistant Professor at Osaka University, Graduate School of Pharmaceutical Sciences. Dr. Fukuda spent over 10 years in the field of Clinical Pharmacology while engaged in Pharmacogenetic research. Dr. Fukuda’s efforts have resulted in over 40 peer-reviewed publications with project members that include Master level and Ph.D. students, clinical fellows, and private sector R & D staff. He was awarded The Japanese Society of Clinical Pharmacology and Therapeutics Research Prize as its youngest recipient in 2003.
Dr. Fukuda joined the Division of Clinical Pharmacology (Prof. Alexander A Vinks, PharmD, PhD) at Cincinnati Children's Hospital Medical Center in 2007. His current research interests include the clinical application of pharmacogenetics and pharmacokinetic-pharmacodynamic (PK/PD) modeling and simulation, focusing on improving our understanding of inter-patient differences in drug response and developing individualized dosing strategies in pediatric patients.

Credentials

BS: Osaka University, School of Pharmacy, Osaka, Japan, 1995

Pharmacist: Japan, 1995

MS: Osaka University, Osaka, Japan,1997

PhD: Osaka University, Osaka, Japan, 2000

Certification: Clinical Pharmacology (Pharmacist), 2003 (Japanese Society of Clinical Pharmacology)

Awards and Honors

  • 1995 Scholarship (1995-1996 MS student), Japan Scholarship Foundation.
  • 1997 Fellowship award (1997-1999 PhD student), Research Fellowships program for Young Scientists, The Japan Society for the Promotion of Science.
  • 2003 Research award, The Japanese Society of Clinical Pharmacology and Therapeutics.
  • 2003 Paper award, at 13th meeting of Japanese Society of clinical Neuropsychopharmacology. (Co-investigator).
  • 2004 Paper award, at 14th meeting of Japanese Society　of clinical Neuropsychopharmacology (Co-investigator).
  • 2005 Best poster award, at 13th Clinical pharmacy symposium (co-investigator).
  • 2005 Best paper award, at 25th meeting of Japanese Society of Clinical Pharmacology (Co-investigator).
  • 2006 Research fellowship, Clinical Pharmacology Research Foundation.
  • 2006 Paper award, at 26th meeting of Japanese Society of Clinical Pharmacology.
  • 2007 Research fellowship, The NAGATOMI Research Foundation.
  • 2007 Paper award, at 27th meeting of Japanese Society of Clinical Pharmacology (Co-investigator).
  • 2007 Travel award(2007-2008), The Japanese Society of Clinical Pharmacology and Therapeutics.

Research

Clinical pharmacology (pharmacogenetics, pharmacokinetics and pharmacodynamics)

Research Grants and Contracts

5U10-HD037249-07 NIH/NICHD Vinks (PI) 01/01/04-12/31/09.
Pediatric Pharmacology Research Unit (PPRU), Role: Co-investigator, pharmacogenetic studies.

Translational Research Initiative, Cincinnati Children’s Hospital Medical Center. Pharmacogenetics of IMPDH in Kidney Transplant Patients.  7/01/08 -6/30/09, Vinks (PI), Role: Co-investigator.

Publications, Most Recent

Prausa SE, Fukuda T, Maseck D, Curtsinger KL, Liu C, Zhang K, Nick TG, Sherbotie JR, Ellis EN, Goebel J and Vinks AA. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.Clin Pharmacol Ther. 2009 May;85(5):495-500. Epub 2009 Feb 18.

Kato M, Fukuda T, Wakeno M, Okugawa G, Takekita Y, Watanabe S, Yamashita M, Hosoi Y, Azuma J, Kinoshita T, Serretti A. Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder.Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):115-23.

Yamamoto A, Nonen S, Fukuda T, Yamazaki H, Azuma J. Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. Drug Metab Pharmacokinet. 2009;24(1):114-7.

Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T. ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.Prog Neuropsychopharmacol Biol Psychiatry. 2008 15; 32(2):398-404.

Wakeno M, Kato M, Okugawa G, Fukuda T, Hosoi Y, Takekita Y, Yamashita M, Nonen S, Azuma J, Kinoshita T. The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran.J Clin Psychopharmacol. 2008 Oct;28(5):518-24.

Kato M, Wakeno M, Okugawa G, Fukuda T, Takekita Y, Hosoi Y, Azuma J, Kinoshita T, Serretti A . Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008 May 15;32(4):1041-4. Epub 2008 Feb 13.

Tougou K, Fukuda T, Ito T, Yamazaki H, Fujio Y and Azuma J. Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.
Drug Metab. Pharmacokinet. 2007;22(2):125-8.

Ito T, Asakura K, Tougou K, Fukuda T, Kubota R, Nonen S, Fujio Y, Azuma J. Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes.
Mol Pharmacol. 2007 Jul;72(1):173-81.

Kubo M, Koue T, Maune H, Fukuda T, Azuma J. Pharmacokinetics of Aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: Influence of CYP2D6 polymorphism.Drug Metab. Pharmacokinet. 22 (5) 2007 Oct;22(5):358-66.

Nakamura N, Ito K, Hongo S, Hashimoto K, Furutsuka M, Kubota R, Fukuda T, Ohno M, Azuma J.Gemma, N. Determination of single nucleotide polymorphisms in N-acetyltransferase 2 gene using an electrochemical DNA chip and an automated DNA detection system. Rinsho Byori 2007;55(3):216-223.

Kato M, Wakeno M, Okugawa G, Fukuda T, Azuma J, Kinoshita T, Serretti A. No association of TPH1 218A/C polymorphism with treatment response and intolerance to SSRIs in Japanese patients with major depression. Neuropsychobiology. 2007;56(4):167-71. Epub 2008 Mar 7.

Koue T, Kubo M, Funaki T, Fukuda T, Azuma J, Takaai M, Kayano Y, Hashimoto Y. Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males.
Biol Pharm Bull. 2007 Nov;30(11):2154-8.

Fukuda T, Yamamoto I, Tanabe T, Ohno M, Tougou K, Takeda H, Fujio Y, Azuma J. Warfarin dose requirement for patients with both VKORC1 3673A/A and CYP2C9*3/*3 genotypes.  Clin Pharmacol Ther. 2006 Nov;80(5):553-4.

Kato M, Fukuda T, Wakeno M, Fukuda K, Okugawa G, Ikenaga Y, Yamashita, Yoshiteru Takekita M, Nobuhara K, Azuma J and Kinoshita T. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology 2006;53(4):186-95.

Kubota T, Nakajima-Taniguchi C, Fukuda T, Funamoto M, Maeda M, Tange E, Ueki R, Kawashima K, Hara H, Fujio Y, Azuma J. CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation. Pharmacogenomics J. 2006 Mar-Apr;6(2):115-9.

Presentations, Most Recent

Tsuyoshi FUKUDA, Masaki Kato, Gaku Okugawa, Masataka Wakeno, Megumi Yamashita, Yuka Ikenaga, Ryuji Kubota, Masako Ohno, Yoshiteru Takekita, Toshihiko Kinoshita, Alexander A Vinks and Junichi Azuma. Association of CYP2D6*10 genotype and smoking status with fluvoxamine pharmacokinetics in patients with depression. American Society of Clinical Pharmacology and Therapeutics. Orlando, Florida, April 2-5, 2008. Clin Pharmacol Ther 2008; 83 (Suppl 1): S69, PII-88.

Tsuyoshi Fukuda, Jens Goebel, Håvard Thøgersen, Shareen Cox, Denise Maseck, Barbara Logan, Alexander A. Vinks. Population modeling of inter-occasion variability of Mycophenolic Acid in Pediatric Kidney Transplant Recipients. The World Conference on Clinical Pharmacology and Therapeutics, Quebec city, Quebec, July 28-August 1, 2008.

Tsuyoshi Fukuda, Susan E. Prausa, Denise Maseck, Kejian Zhang, Todd G. Nick, Chunyan Liu, Jens Goebel and Alexander A.Vinks. UGT polymorphisms may contribute to side effects of mycophenolate mofetil in pediatric kidney transprant recipients. American Society of Clinical Pharmacology and Therapeutics. Washington DC, March 18-21, 2009.

Tsuyoshi Fukuda, Susan E. Prausa, Denise Maseck, David Hooper, Chunyan Liu, Kejian Zhang, Todd G. Nick, Jens Goebel and Alexander A.Vinks. UGT and ABCB1 Polymorphisms may be associated with Leucopenia following Mycophenolic acid therapy in pediatric kidney transplant recipients. 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology Montréal, Québec, Canada, October 3-8, 2009 (scheduled).

Professional Organization Memberships

  • Japanese Society of Pharmacology
  • Japanese Society of Clinical Pharmacology and Therapeutics (certifying pharmacist, 2003)
  • Japanese Society for the study of Xenobiotics
  • American Society of Clinical Pharmacology and Therapeutics