Anne-Karina T. Perl, MS, PhD
Appointment
Assistant Professor of Pulmonary Biology, University of Cincinnati College of Medicine
Email
anne.perl@cchmc.org
Phone
513-636-6084
Fax
513-636-7868
Credentials
PhD: University of Vienna, Austria, 1998
Position History
March 1998 to October 1998Postdoctoral fellow at the Research Institute of Molecular Pathology, Vienna, Austria in the group of Dr. G. Christofori. The molecular dissection of multi-stage tumorigenesis in transgenic mice.
January 1999 to August 2002Postdoctoral fellow in the lab of Dr. Jeffrey Whitsett, (Cincinnati Children’s Hospital Medical Center, Ohio, USA). Work on FGF signalling during lung morphogenesis and cell fate mapping in early lung development
September 2002 to Present Assistant Professor of Pulmonary Biology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, OH, USA
Awards and Honors
- 2009 - 2011 Biomedical research grant from the American Lung Association
- 2007 - 2009 Grant in Aid from the American Heart Association
- May 2000 to May 2001 Second year extension of FWF Erwin Schrödinger Fellowship J1959-GEN for work on FGF and FGFR signaling during lung morphogenesis
- May 1999 to May 2000 Stipend with a FWF Erwin Schrödinger Fellowship J1746-GEN for work on FGF and FGFR signaling during lung morphogenesis
- September 1998 Young Scientist of the year 1998 of the Austrian Society of Genetics and Gentechnology
Research
Visit the Perl Lab.
Research Grants and Contracts
• Current Awards:
Biomedical Research Grant from the American Lung Association:
The role of EGF receptor in regenerating airway epithelium and airway thickening
Grant in Aid from American Heart Association:
6/30/07-7/1/09
Title of Research Project: Regulation of PDGFRa expression and role of FGF signaling in PDGFRa mediated alveolar myofibroblast differentiation
RFA-HL 07-003 NIH/NHLBI; (Whitsett)
9/28/2007-2011
Collaborative Studies on lung stem cell biology and cell based Therapy.
• Past Awards:
P50 HL56387-07 NIH/NHLBI (Whitsett/ Shannon)
9/30/01-7/31/06
Specialized Center of Research (SCOR), peer reviewed.
Fibroblast Growth Factors in Lung Morphogenesis: The major goals of this project are: 1) To define the role of FGF-10 in lung epithelial cell growth and differentiation; 2) To determine the FGFs that are involved in specification of the distal lung epithelial phenotype; 3) To determine the effects of FGFs on lung morphogenesis and differentiation during late gestation and alveolarization; 4) To determine the role of FGFs in the response of the neonatal lung to oxidant injury.
5P50 HL56387-07 NIH/NHLBI (Whitsett)
9/30/01-7/31/06
Co-investigator with 50% of professional effort
Specialized Center of Research (SCOR), peer reviewed.
Transcriptional Control of Respiratory Epithelial Cell Differentiation (TTF-1, HNF-3B):
The major goals of this project are 1a) Pulmonary cell lineage analysis using dox-regulated, cre-lox cell marking; 1b) identification of respiratory epithelial stem cells and lineage, with ALV-A; 2) role of TTF-1 in lung morphogenesis and respiratory epithelial cell differentiation; 3) role of HNF-3B on lung morphogenesis and respiratory epithelial cell differentiation; and 4) role of TTF-1 and HNF-3B in pathogenesis of congenital malformations and repair of the developing human lung.
J 1746-Gen & J1959-GEN FWF Erwin Schrödinger Fellowship.
05/1999-05/2001
Postdoctoral Stipend for work on FGF and FGFR signalling during lung morphogenesis
Publications, Most Recent
Perl AK, Gale E. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. Am J Physiol Lung Cell Mol Physiol 2009;297(2):L299-308.
Perl AK, Zhang L, Whitsett JA. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol 2009;40(1):1-3.
Jäggi F, Cabrita MA, Perl, AK, Christofori G.Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4. Mol Cancer Res 2008;6(3):468-82.
Perl AK. Development biology of the lungs as sample of regenerative therapy approach. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 2007;57(11):743-5.
Whitsett JA, Perl AK. Conditional control of gene expression in the respiratory epithelium: A cautionary note. Am J Respir Cell Mol Biol 2006;34(5):519-20.
Lin S, Perl, AK, Shannon JM. Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. J Biol Chem 2006;281(24):16716-26.
Martis PC, Whitsett JA, Xu Y, Perl, AK, Wan H, Ikegami M. C/EBP{alpha} is required for lung maturation at birth. Development 2006;133(6):1155-64.
Perl AK, Wert SE, Loudy DE, Shan Z, Blair PA, Whitsett JA. Conditional Recombination Reveals Distinct Subsets of Epithelial Cells in Trachea, Bronchi, Alveoli.Am J Respir Cell Mol Biol. 2005 Jul 29.
Perl AK, Ralf Kist R, Shan ZY, Scherer G, Whitsett JA. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 2005;41(1):23-32.
Miller LA, Wert SE, Clark JC, Xu Y, Perl AK, Whitsett JA. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 2004;231(1):57-71.
Hokuto I, Ikegami, M, Yoshida M., Takeda K Akira S, Perl AK, Hull W , Wert S, Whitsett JA. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 2004;113(1):28-37.
Hokuto I, Perl AK, Whitsett JA. FGF-signaling is required for pulmonary homeostasis following hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2003 Nov 14.
Perl AK, Impagniatello MA, Christofori G, Whitsett JA. Temporal Effects of Sprouty on Lung Morphogenesis. Dev Biol 2003;258(1):154-68.
Hokuto I, Perl AKT, Whitsett JA. (Co-first author). Prenatal, but not postnatal inhibition of FGF-receptor signalling causes emphysema. J Biol Chem 2003;278:415-21.
Perl AKT, Wert SE, Nagy A, Lobe CG, Whitsett JA. Early restriction of peripheral and proximal cell lineages during formation of the lung. PNAS 2002;99:10482-7.
Whitsett JA, Clark JC, Picard L, Tichelaar JW, Wert SE, Itoh N, Perl AK, Stahlman MT. Fibroblast growth factor 18 influences proximal programming during lung morphogenesis. J Biol Chem 2002;277(25):22743-9.
Perl AK, Tichelaar J, Whitsett J. Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res 2002;11(1):21-9.
Professional Organization Memberships
- Women Faculty Association (WFA)
- American Thoracic Society (ATS)
- Society for Developmental Biology (SDB)
- American Physiological Society (AJP)
Special Interests
Lung development and lung regeneration
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
