Pulmonary Biology

Cindy J. Bachurski, PhD

Title

Director, Neonatology and Pulmonary Biology Elective Rotation, University of Cincinnati, School of Medicine

Director, High School Senior Summer Internship Program, Cincinnati Children's Hospital Medical Center

Director, Excellence in Science Education and Learning (ExSEL) II Program, PATHWAYS to Health Careers, University of Cincinnati College of Medicine

Appointment

Associate Professor of Pediatrics, University of Cincinnati College of Medicine

Email

cindy.bachurski@cchmc.org

Phone

513-636-8918

Fax

513-636-7868

Bio

Cindy Bachurski, PhD, is an Associate Professor in the Division of Pulmonary Biology at Cincinnati Children's Research Foundation (CCRF) and the Department of Pediatrics at the University of Cincinnati.

Dr. Bachurski's laboratory studies transcriptional control of the establishment and maintenance of the pulmonary Type II cell. She uses sophisticated transgenic mouse technology and molecular and biochemical analysis methods to ask mechanistic questions about transcription factor interactions during lung development, and in response to injury.

Credentials

PhD: Microbiology, University of Maryland, College Park, MD, 1990.

Postdoctoral Fellowship: Biological Chemistry, Johns Hopkins University, Baltimore, MD, 1990 to 1992.

Postdoctoral Fellowship: Pulmonary Biology, Children's Hospital Research Foundation, Cincinnati, OH, 1992 to 1994.

Awards and Honors

National Research Service Award Fellowship in Perinatology, 1992 to 1994
American Lung Association Research Award, 1995 to 1997
Charlotte R. Schmidlapp Women Scholars Award, 1999 to 2001

Research

Epithelial remodeling in lung injury / repair
Transcription factor interactions in lung development
Regulation of the Type II cell phenotype / lung epithelial progenitor cells
Regulation of late lung development / BPD

Research Grants and Contracts

NIH R21 HL093706 (PI: CJ Bachurski) 3/1/09- 2/28/11
Novel Model of Adult Lung Epithelial Stem Cell Expansion. To determine the mechanism of NFIen induced lung epithelial stem cell expansion and reprogramming in adult mice and to develop methods to isolate and study these cells in vitro.

To support mentoring of young women in science and medicine at CCHMC. Schmidlapp Foundation Fifth/Third Bank (PI: SJ Degen) 5/1/05- 4-30/10. Charlotte R. Schmidlapp Center for Career Development of Women in Academic Pediatrics This supports my efforts in the High School Science Symposium and Summer Internship Programs.

HHMI Precollege Outreach Initiative for Biomedical Research Institutions (PI: Stern)
Mentoring Community Outreach Grant 9/1/07- 8/31/12
Role: CCHMC liaison
Supports several UC K-12 community outreach programs and two new joint programs with CCHMC:
1]Science-on-Wheels van for elementary school science outreach.
2] ExSEL II program. I direct this 9week program and interact bi-weekly with the students for lunch/mentoring sessions throughout the summer.

NIHU54RR025216-01 (PIs: Heubi and Tsevat) 4/01/09- 3/31/14
Cincinnati Center for Clinical and Translational Science and Training
Role: CCHMC liaison for high school outreach
To support clinical and translational research activities at the University of Cincinnati Health Sciences complex including community outreach programs.

Publications, Most Recent

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. Surfactant associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol 2009 Jan 16. [Epub ahead of print]

Kessler CA, Bachurski CJ, Schroeder J, Stanek J, Handwerger S. TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells. Mol Cell Endocrinol 2008;295: 32-8.

Hillman NH, Moss TJ, Nitsos I, Kramer BW, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptor and Agonist Responses in the Developing Fetal Sheep Lung. Pediatr Res Pediatr Res 2008;63:388-93.

Hillman NH, Moss TJ, Kallapur SG, Bachurski C, Pillow JJ, Polglase GR, Nitsos I, Kramer BW, Jobe AH. Brief, Large Tidal Volume Ventilation Initiates Lung Injury and a Systemic Response in Fetal Sheep. Am J Respir Crit Care Med 2007;176: 575-81.

Wilson TC, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs. Pediatr Res 2005;58:1204-9.

Steele-Perkins G, Plachez C, Butz KG, Yang G, Bachurski CJ, Kinsman SL, Litwack ED, Richards LJ, Gronostajski RM. The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development. Mol Cell Biol 2005;25:685-98.

Bachurski CJ, Yang GH, Currier TA, Gronostajski R, Hong D. Nuclear Factor I / Thyroid Transcription Factor 1 interactions modulate Surfactant Protein C transcription. Molecular Cellular Biology 2003;23:9014-24.

DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC, Whitsett JA. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival and tissue specific gene expression. Journal of Biological Chemistry 2003;278:35574-83.

Ikegami MI, Moss TJ, Kallapur SG, Mulrooney N, Kramer BW, Nitsos I, Bachurski CJ, Newnham JP, Jobe AH. Minimal lung and systemic responses to TNFin preterm sheep. American Journal of Physiological Lung Celleular Molecular Physiology 2003;285:L121-9.

Kallapur SG, Kramer BW, Moss TJM, Newnham JP, Jobe AH, Ikegami M, Bachurski CJ. Maternal glucocorticoids increase endotoxin induced lung inflammation in preterm lambs. American Journal of Physiological Lung Cellular Molecular Physiology 2003;284(4):L633-42.

Kallapur SG, Jobe AH, Ikegami M, Bachurski CJ. Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung. American Journal of Respiratory Critical Care Medicine 2003;167(5):779-86.

McDowell SA, Gammon K, Zingarelli B, Bachurski CJ, Aronow BJ, Prows DR, Leikauf GD. Inhibition of NO restores surfactant gene expression following nickel-induced acute lung injury. American Journal of Respiratory Cell Molecular Biology 2003;28:188-98.

McDowell SA, Mallakin A, Bachurski CJ, Toney-Earley K, Prows DR, Bruno T, Kaestner KH, Witte DE, Melin-Aldana H, Degen SJF, Leikauf GD, Waltz SE. The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. American Journal of Respiratory Cell Molecular Biology 2002;26:99-104.

Naik AS, Kallapur SG, Bachurski CJ, Jobe AH, Michna J, Kramer BW, Ikegami M. Effects of ventilation with different PEEP on cytokine expression in the preterm lamb lung. American Journal of Respiratory Critical Care Medicine 2001;164:1-5.

Towne JE, Krane CM, Bachurski CJ, Menon AG. Tumor necrosis factor alpha inhibits aquaporin 5 expression in mouse lung epithelial cells. Journal of Biological Chemistry 2001;276:18657-64.

Watanabe K, Kesslar CA, Bachurski CJ, Kanda Y, Richardson BD, Stanek J, Handwerger S, Brar AK. Identification of a decidua-specfic enhancer on the human prolactin gene with two critical AP-1 binding sites. Molecular Endocrinology 2001;15:638-53.

Bachurski CJ, Ross GF, Ikegami M, Kramer BW, Jobe AH. Intra-amniotic endotoxin increases pulmonary surfactant components and induces SP-B processing in fetal sheep. American Journal of Physical Lung Cellular Molecular Physiology 2001;280:L279-85.

Kramer BW, Jobe AH, Bachurski CJ, Ikegami M. Surfactant protein A recruits neutrophils into the lungs of ventilated preterm sheep. American Journal of Respritory Critical Care Medicine 2001;163:158-65.

Presentations, Most Recent

Nuclear Factor IB and Thryoid Transcription Factor1 Synergistically Regulate Fetal Lung Maturation. Bachurski CJ, Sarawgi S, Kellermeyer B, Gronostajski RM, Wert SE. Am J Resp Crit Care Med [CJB talk at ATS International Conference, San Diego, CA, May 2009].

Career Talk for Graduate Students. May. 2009, Sunrise Seminar Series at the American Thoracic Society International Conference San Diego, CA May 2009.

Dominant negative Nuclear Factor 1 (NFIen) expression induces cell proliferation and polyp formation in the adult lung. Bachurski CJ, Patel D, The TW, Wert SE. Am J Resp Crit Care Med 175:A299 [CJB talk at American Thoracic Society International Conference, San Diego, CA May 2007].

Epithelial Plasticity in the Lung: Can the Stem Cell Phenotype be Reinitiated in Adult Lung? Mar. 2007 Biology Dept. Seminar Series, Ball State University, Muncie, IN.

NFIB2 regulates pulmonary goblet cell hyperplasia. Bachurski CJ, The TW, Besnard V, Whitsett JA. Presented at the FASEB Conference on Lung Surfactant: Cellular and Molecular Biology, Snowmass, CO, Aug. 2006. Also served as chair of Genetic Control of Lung Development session.

Multiple roles of Nuclear Factor I-B in lung development. Sept. 2005. National Jewish Medical and Research Center, Dept of Medicine, University of Colorado, Denver CO.

Professional Organization Memberships

Special Interests

In addition to mentoring graduate students, post-doctoral and clinical fellows, Cindy has a long-term interest in mentoring young scientists. She organized a Research Explorer Scout Troop for high school students (1997 to 2001). She is currently the director of the Summer Internship Program at Cincinnati Children's, for graduating high school students to work with clinician-mentors. She also co-chairs the Cincinnati Children's High School Science Symposium honoring outstanding, local high school students and their teachers.

She is an active member of the Cincinnati Children's Women's Faculty Association where she has chaired several committees, organized workshops on Mentoring, and the Faculty Development page for the Cincinnati Children's web site.

Starting in the summer of 2008, Dr. Bachurski also directs the ExSELII program in which the best students from the Howard Hughes Medical Institute funded ExSEL program are invited to work full time on a mentored research lab project for 9 weeks in the summer. Click here to access the HHMI summer programs.