Cindy J. Bachurski, PhD
Title
Director, Neonatology and Pulmonary Biology Elective Rotation, University of Cincinnati, School of Medicine.
Appointment
Associate Professor of Pediatrics, Affiliated
Email
cindy.bachurski@cchmc.org
Phone
513-636-8918
Fax
513-636-7868
Bio
Cindy Bachurski, PhD, is an Associate Professor in the Division of Pulmonary Biology at Cincinnati Children's Research Foundation (CCRF) and the Department of Pediatrics at the University of Cincinnati.
Dr. Bachurski received her PhD from the University of Maryland in 1990, and did post-doctoral training with Don Cleveland at Johns Hopkins University, and Jeff Whitsett at Cincinnati Children's before joining the faculty at CCHRF in 1994.
Dr. Bachurski's laboratory studies transcriptional control of the establishment and maintenance of the pulmonary Type II cell phenotype. She uses sophisticated transgenic mouse technology and molecular and biochemical analysis methods to ask mechanistic questions about transcription factor interactions during lung development and in response to injury.
Her early work was funded by the CF Foundation (1994 to 1996), and an ALA Research Award (1995 to 97). She received a Charlotte Schmidlapp Foundation Women Scholars Award (1999 to 2000) and has been NIH funded since 1998. Dr. Bachurski has also served on grant peer review committees for both the American Lung and Heart Associations.
Credentials
PhD Microbiology, University of Maryland, College Park, MD, 1990.
Postdoctoral Fellowship Biological Chemistry, Johns Hopkins University, Baltimore, MD, 1990 to 1992.
Postdoctoral Fellowship Pulmonary Biology, Children's Hospital
Research Foundation, Cincinnati, OH, 1992 to 1994.
Awards and Honors
- National Research Service Award Fellowship in Perinatology, 1992 to 1994
- American Lung Association Research Award, 1995 to 1997
- Charlotte R. Schmidlapp Women Scholars Award, 1999 to 2001
Research
- Epithelial remodeling in lung injury / repair
- Transcription factor interactions in lung development
- Regulation of the Type II cell phenotype
- Regulation of late lung development / BPD
Research Grants and Contracts
National Institute of Health R01 HL60907 (Prinicpal Investigator), Role of NFI in Type II cell function.
National Institute of Health R01 HL65397 (Co-Investigator), New mediators of lung maturation.
- National Institute of Health R01 HD12714 (Co-Investigator), Antecedents to lung injury in the preterm.
Publications, Most Recent
Kramer BW, Jobe AH, Bachurski CJ and Ikegami M: Surfactant protein A recruits neutrophils into the lungs of ventilated preterm sheep. American Journal of Respritory Critical Care Medicine 163:158-165, 2001.
Bachurski CJ, Ross GF, Ikegami M, Kramer BW and Jobe AH: Intra-amniotic endotoxin increases pulmonary surfactant components and induces SP-B processing in fetal sheep. American Journal of Physical Lung Cellular Molecular Physiology 280:L279-L285, 2001.
Kallapur SG, Willet KE, Jobe AH, Ikegami M, Naik AS and Bachurski CJ: Cytokine and inflammatory response of amnion / chorion and lung to intra-amniotic endotoxin in fetal sheep. American Journal of Physiological Lung Cellular Molecular Physiology 280:L527-L536, 2001.
Watanabe K, Kesslar CA, Bachurski CJ, Kanda Y, Richardson BD, Stanek J, Handwerger S and Brar AK: Identification of a decidua-specfic enhancer on the human prolactin gene with two critical AP-1 binding sites. Molecular Endocrinology 15:638-653, 2001.
Towne JE, Krane CM, Bachurski CJ and Menon AG: Tumor necrosis factor alpha inhibits aquaporin 5 expression in mouse lung epithelial cells. Journal of Biological Chemistry 276:18657-18664, 2001.
Naik AS, Kallapur SG, Bachurski CJ, Jobe AH, Michna J, Kramer BW and Ikegami M: Effects of ventilation with different PEEP on cytokine expression in the preterm lamb lung. American Journal of Respiratory Critical Care Medicine 164:1-5, 2001.
McDowell SA, Mallakin A, Bachurski CJ, Toney-Earley K, Prows DR, Bruno T, Kaestner KH, Witte DE, Melin-Aldana H, Degen SJF, Leikauf GD and Waltz SE: The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. American Journal of Respiratory Cell Molecular Biology 26:99-104, 2002.
McDowell SA, Gammon K, Zingarelli B, Bachurski CJ, Aronow BJ, Prows DR and Leikauf GD: Inhibition of NO restores surfactant gene expression following nickel-induced acute lung injury. American Journal of Respiratory Cell Molecular Biology 28:188-98, 2003.
Kallapur SG, Jobe AH, Ikegami M and Bachurski CJ: Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung. American Journal of Respiratory Critical Care Medicine 167(5):779-786, 2003 (cover story).
Kallapur SG, Kramer BW, Moss TJM, Newnham JP, Jobe AH, Ikegami M and Bachurski CJ: Maternal glucocorticoids increase endotoxin induced lung inflammation in preterm lambs. American Journal of Physiological Lung Cellular Molecular Physiology 284(4):L633-642, 2003.
Ikegami MI, Moss TJ, Kallapur SG, Mulrooney N, Kramer BW, Nitsos I, Bachurski CJ, Newnham JP and Jobe AH: Minimal lung and systemic responses to TNFin preterm sheep. American Journal of Physiological Lung Celleular Molecular Physiology 285:L121-L129, 2003.
DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC and Whitsett JA: TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival and tissue specific gene expression. Journal of Biological Chemistry 278: 35574-35583, 2003.
Bachurski CJ, Yang GH, Currier TA, Gronostajski R and Hong D: Nuclear Factor I / Thyroid Transcription Factor 1 interactions modulate Surfactant Protein C transcription. Molecular Cellular Biology 23: 9014-9024, 2003.
Professional Organization Memberships
Service
- Director, CCHMC Summer Internship Program for High School Students
- Director, Neonatology & Pulmonary Biology Elective Rotation, University of Cincinnati School of Medicine
- Member, Editorial Committee, CCHMC Staff Bulletin
- Member, CCHMC Women's Faculty Association
- Peer Reviewer, Department of Defense, Congressional Interest Research on Health-Related Topics, 2002
- Grant Review Committee Member, American Lung Association Grant Review Committees, 2000-2003
- Ad-hoc Program Project Grant Reviewer, National Institute of Environmental Health Sciences and National Institutes of Health, 2001
- Grant Review Committee, American Heart Association, 2004
- Reviewer, NHLBI T24 training grants, 2004
Special Interests
In addition to mentoring graduate students, post-doctoral and clinical fellows, Cindy has a long-term interest in mentoring young scientists. She organized a Research Explorer Scout Troop for high school students (1997 to 2001). She is currently the director of the Summer Internship Program at Cincinnati Children's, for graduating high school students to work with clinician-mentors. She also co-chairs the Cincinnati Children's High School Science Symposium honoring outstanding, local high school students and their teachers.
She is an active member of the Cincinnati Children's Women's Faculty Association where she has chaired several committees, organized workshops on Mentoring, and the Faculty Development page for the Cincinnati Children's web site.
Learn more about the High School Science Symposium and Summer Internship Program for Science Students.
Platform Presentations
Bachurski CJ, Yan C and Hong D: Thyroid transcription factor 1 (TTF-1) / nuclear factor I (NFI) interactions modulate transcription of pulmonary surfactant protein-C.American Journal of Respitory Critical Care Medicine 163:A963. Presented at ATS International Conference, San Francisco, CA, 2001.
Invited Lectures
Transcription factor interactions in regulation of pulmonary surfactant protein-C gene expression. Developmental Biology Seminar Series, Cincinnati Children's Hospital, 2001.
Mechanism of SP-C gene regulation by TNF mediated signal transduction. Cell Signalling Club, University of Cincinnati, 2001.
Regulation of surfactant protein gene expression in acute lung injury. The Institute for Environmental Medicine, University of Pennsylvania, 2002.
Dissecting the role of Nuclear Factor I in Type II cell differentiation and in Clara Cell / Neuroendocrine Cell interactions. Department of Environmental and Occupational Health, University of Pittsburgh, 2002.
Mechanisms of regulation of SPC transcription. FASEB Conference on Surfactant, Saxton's River, VT, 2004.
Surfactant protein gene regulation in acute lung injury: mechanism of SP-C inhibition by TNF alpha signaling. Department of Surgery, University of Cincinnati.
Regulation of SP-C transcription in acute lung injury models. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, PR, China, 2004.
Sheep model of chorioamnionitis induced fetal lung maturation. Children's Hospital of Zhejiang University School of Medicine, Huanzhou, PR, China, 2004.
Mechanisms of surfactant protein gene regulation in models of lung development and acute lung injury. Children's Hospital of Zhejiang University School of Medicine, Huanzhou, PR, China, 2004.
Transcription factor interactions in regulation of lung development. Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR, China, 2004.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
