Tim Le Cras, PhD
Title
Director of Graduate Student Recruiting, Molecular & Developmental Biology Graduate Program
Appointment
Associate Professor of Pediatrics
Email
tim.lecras@cchmc.org
Phone
513-636-8151
Credentials
BSc, Applied Biochemistry, Brunel University, London, UK, 1983-1987
PhD, Molecular Biology, University of Cambridge, UK, 1988-1992
Postdoctoral fellow, University of Virginia, Charlottesville, Virginia, 1993-1996
Position History
1996-1998 Instructor, Department of Pediatrics, University of Colorado, Denver, Colorado
1998-2001 Assistant Professor, Department of Pediatrics, University of Colorado, Denver, Colorado
2001-present Assistant Professor, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center
2003-present Member of Molecular & Developmental Biology Graduate Faculty, University of Cincinnati
2005-present Associate Professor, Section of Neonatology, Perinatal & Pulmonary Biology, Cincinnati Children's Hospital Medical Center
Awards and Honors
1987 B.Sc. in Biochemistry with Honors, Brunel University, London, UK
1996 Postdoctoral Fellowship Award, American Heart Association (2 years)
1997 Grant-in-Aid, American Heart Association (1 year)
1998 Grant-in-Aid, American Heart Association (2 years)
1999 Scientist Development Grant, American Heart Association (4 years)
2002 Showcased Abstract & Travel Award at ATS 2002 98th International Conference
2003 R01, National Institutes of Health/NHLBI (4 years)
2003 Career Investigator Award, American Lung Association (3 years)
2003 Showcased Abstract , Pulmonary Circulation Assembly, ATS 2003 99th Conference
2005 NIH grant reviewer for Special Emphasis panel (Study Sections RIBT & LIRR)
2006 Grant-in-Aid, American Heart Association (2 years)
Publications, Most Recent
TD Le Cras, LG Fernandez, and VE Laubach. (2005) Vascular growth and remodeling in compensatory lung growth following right pneumonectomy. J. Appl. Physiol. 98:1140-1148
TD Le Cras, WD Hardie, JA Whitsett, and TR Korfhagen. (2004) Transient induction of TGF- disrupts lung morphogenesis, causing pulmonary disease in adulthood.Am. J. Physiol. (Lung Cell Mol. Physiol.) 287: L718-729
TD Le Cras, RE Spitzmiller, JM Greenberg, JA Whitsett, and L Akeson. (2004) VEGF causes pulmonary hemorrhage, hemosiderosis, and airspace enlargement in neonatal mice.Am. J. Physiol. (Lung Cell Mol. Physiol.) 287: L134-142
TD Le Cras, WD Hardie, K Fagan, JA Whitsett, and TR Korfhagen. (2003) Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing Transforming growth factor- .Am. J. Physiol. (Lung Cell Mol. Physiol.) 285 (5): L1046-L1054
TD Le Cras, N Markham, R Tuder, NF Voelkel, and SH Abman. (2002) Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.Am. J. Physiol. (Lung Cell Mol. Physiol.) 283: L555-L562
TD Le Cras and IF McMurtry. Nitric oxide production in the hypoxic lung. (2001) Am. J. Physiol. (Lung Cell Mol. Physiol.) 280: L575-L582
TD Le Cras, NE Markham, KG Morris, CR Ahrens, IF McMurtry, and SH Abman. (2000) Neonatal dexamethasone treatment increases the risk for development of pulmonary hypertension in adult rats.Am. J. Physiol. (Lung Cell Mol. Physiol.) 278 (4): L822-830
TD Le Cras, D Kim, NE Markham, and SH Abman. (2000) Early abnormalities in pulmonary vascular development in the Fawn-Hooded rat raised at altitude.Am. J. Physiol. (Lung Cell Mol. Physiol.) 279 : L283-291
M Jakkula, TD Le Cras, S Gebb, KP Hirth, RM Tuder, NF Voelkel, and SH Abman. (2000) Inhibition of angiogenesis decreases alveolarization in the developing rat lung.Am. J. Physiol. (Lung Cell Mol. Physiol.) 279: L600-607
Y Kasahara, RM Tuder, L Taraseviciene-Stewart, TD Le Cras, S Abman, PK Hirth, J Waltenberger, and NF Voelkel. (2000) Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106:1311-1319
Book Chapter
SH Abman, JP Kinsella, TA Parker, L Storme, and TD Le Cras. (2000) Physiologic roles of nitric oxide in the perinatal pulmonary circulation. In, The Fetal and Neonatal Pulmonary Circulations. Weir EK SL Archer, and JT Reeves, editors. Armonk NY Futura Publishing Company.
Find more publications by Dr. Le Cras through PubMed.
Professional Organization Memberships
American Physiological Society, 1999-present
American Heart Association (Cardiopulmonary & Critical Care Council), 1999-present
American Thoracic Society (Pulmonary Circulation Assembly), 2002-present
Journal Review
Am. J. Physiol. (Lung Cell Mol. Physiol.)
Am. J. Resp. Cell Mol. Biol.
Am. J. Resp. Crit. Care Med.
Pediatric Research
Eur. Resp. J.
Development
J. Appl. Physiol.
Grant Review: NIH NHLBI Respiratory Physiology study (RESP) section (March 2002)
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
