Tim Le Cras, PhD
Title
Director of Admissions, Molecular & Developmental Biology Graduate Program
Appointment
Associate Professor of Pediatrics, University of Cincinnati College of Medicine
Email
tim.lecras@cchmc.org
Phone
513-636-8151
Fax
513-636-7868
Bio
The goal of my laboratory is to investigate the causes of chronic lung diseases, including pulmonary hypertension, bronchopulmonary dysplasia, pulmonary fibrosis, and asthma. Our goal is to use this knowledge to identify therapeutic targets and preventative measures. Our efforts are aided by very productive collaborations with other groups at Cincinnati Children’s as well as other groups in the U.S.
Credentials
Postdoctoral fellow: University of Virginia, Charlottesville, Virginia, 1993-1996
PhD: Molecular Biology, University of Cambridge, UK, 1988-1992
BSc: Biochemistry, Brunel University, London, UK, 1983-1987
Position History
2005-present Associate Professor, Section of Neonatology, Perinatal & Pulmonary Biology, Cincinnati Children's Hospital Medical Center
2001-2005 Assistant Professor, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center
1998-2001 Assistant Professor, Department of Pediatrics, University of Colorado, Denver, Colorado
1996-1998 Instructor, Department of Pediatrics, University of Colorado, Denver, Colorado
Awards and Honors
NIH Reviewer NHLBI RESP study section 2002, 2005, 2008
National American Heart Association (Lung Respiration study section) reviewer 2007, 2008
Established Investigator Award, American Heart Association, 2007-2011
Tenure awarded at Associate Professor level, University of Cincinnati, 2008
Research
- Lung Development
- Bronchopulmonary Dysplasia
- Pulmonary Hypertension
- Asthma
- Pulmonary Fibrosis
Publications, Most Recent
Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Egr-1 suppresses EGFR-mediated airway hyperresponsiveness and lung remodeling in mice.Am J Respir Cell Mol Biol 2009;Feb 2, Epub PMID: 19188657.
Kramer EL, Deutsch GH, Sartor M, Ikegami M, Hardie WD, Korfhagen TR, Le Cras TD. Perinatal induction of TGF-a disrupts the saccular phase of lung morphogenesis and causes remodeling: Microarray analysis.Am J Physiol (Lung Cell Mol Physiol) 2007;293:L314-27.
Le Cras TD, Fernandez LG, Laubach VE. Vascular growth and remodeling in compensatory lung growth following right pneumonectomy.J Appl Physiol 2005;98:1140-8.
Editorial on Le Cras Lab publications: D. Massaro and G. DeCarlo Massaro. Critical period for alveologenesis and early determinants of adult pulmonary disease.Am J Physiol Lung Cell Mol Physiol 2004;287: L715-7.
Le Cras TD, Hardie WD, Whitsett JA, Korfhagen TR. Transient induction of TGF-a disrupts lung morphogenesis, causing pulmonary disease in adulthood.Am J Physiol (Lung Cell Mol Physiol) 2004;287: L718-29.
Le Cras TD, Spitzmiller RE, Greenberg JM, Whitsett JA, Akeson L. VEGF causes pulmonary hemorrhage, hemosiderosis, and airspace enlargement in neonatal mice.Am J Physiol (Lung Cell Mol Physiol) 2004;287: L134-42.
Le Cras TD, Markham N, Tuder R, Voelkel NF, Abman SH. Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.Am J Physiol (Lung Cell Mol Physiol) 2002;283: L555-62.
Le Cras TD, McMurtry IF. Nitric oxide production in the hypoxic lung.Am J Physiol (Lung Cell Mol Physiol) 2001;280:L575-82.
Le Cras TD, Kim D, Markham NE, Abman SH. Early abnormalities in pulmonary vascular development in the Fawn-Hooded rat raised at altitude.Am J Physiol (Lung Cell Mol Physiol) 2000;279:L283-91.
Le Cras TD, Markham NE, Morris KG, Ahrens CR, McMurtry IF, Abman SH. Neonatal dexamethasone treatment increases the risk for development of pulmonary hypertension in adult rats. Am J Physiol (Lung Cell Mol Physiol) 2000;278(4):L822-30.
Le Cras TD, Kim D, Gebb S, Markham NE, Shannon JM, Ruder RM, Abman SH. Abnormal lung growth and the development of pulmonary hypertension in the fawn-hooded rat.Am J Physiol (Lung Cell Mol Physiol) 1999;277:L709-18.
Presentations, Most Recent
Experimental Biology (FASEB) meeting, 2009. Invited speaker for Am. Assoc. Anatomists - Master Class in Anatomy – The Lower Respiratory System
Vanderbilt University, Pediatric Dept. Research Seminar & Neonatology Div. Seminar; 2007.
Columbus Children’s Research Institute, Columbus Children’s Hospital, Columbus, OH; 2007.
Neonatology Dept., Northwestern University & Children’s Memorial Hospital, Chicago, IL; 2007.
Society for Pediatric Research International Conference 2005, Washington, DC; symposium talk.
Professional Organization Memberships
Journal Review
Am. J. Physiol. (Lung Cell Mol. Physiol.)
Am. J. Resp. Cell Mol. Biol.
Am. J. Resp. Crit. Care Med.
Pediatric Research
Eur. Resp. J.
Development
J. Appl. Physiol.
Grant Review: NIH NHLBI Respiratory Physiology study (RESP) section (March 2002)
Additional Responsibilities
Other responsibilities include teaching in the graduate level courses at University of Cincinnati and the Molecular & Developmental Biology (MDB) Graduate Program. In addition, coordinating admissions to the MDB graduate program.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
