Pulmonary Biology

Machiko Ikegami, MD, PhD

Appointment

Professor of Pediatrics, University of Cincinnati College of Medicine

Email

machiko.ikegami@cchmc.org

Phone

513-636-8661

Fax

513-636-8691

Bio

Dr. Ikegami contributed in development of surfactant treatment for immature newborns with respiratory distress syndrome. She is internationally renowned for her research in surfactant biology and pulmonary biology.

Dr. Ikegami is the author of over 300 papers in the basic science.

Credentials

MD: Tokyo Women's Medical University, Tokyo, Japan, 1971

PhD: Tokyo Women's Medical University, Tokyo, Japan, 1980

Residency, Fellowships: Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan, 1971-1975

Position History

Professor of Pediatrics, Cincinnati Children’s Hospital Medical Center University of Cincinnati, Cincinnati, Ohio, 1997 - present
Professor of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, 1993-1997
Associate Professor, of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, 1987-1993
Assistant Professor of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, 1979-1987
Research Pediatrician, Harbor-UCLA Medical Center, Torrance, California, 1978-1979
Research Pediatrician, University of California-Los Angeles, Los Angeles, California, 1975-1978

Research

Transcriptional control of lung morphogenesis
Molecular mechanisms of recovery from lung injury
Surfactant biology

Research Grants and Contracts

NIH-NHLBI - R01: Role of C/EBPa in cytoprotection and recovery from lung injury. 4/2009-3/2013, Principal Investigator

March of Dimes: Efficacy of SP-D containing surfactant for treatment of premature newborns. 6/2009-5/2012, Principal Investigator

NIH-NHLBI - R01: Neonatal resuscitation and preterm lung injury. 5/2006-3/2011, Co-Investigator

NIH-NHLBI - R01: Role of HIF-a in fetal lung epithelium differentiation. 12/2006-11/2011, Co-Investigator

NIH-NHLBI - R01: Transcriptional programming of asthma related pathology in respiratory epithelial. 4/2009-3/2014, Co-Investigator

Publications, Most Recent

Ikegami M, Grant S, Korfhagen T, Scheule RK, Whitsett JA. Surfactant Protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes.J Appl Physiol, In press.

Kallapur S, Nitsosw I, Moss TJM, Polglase G, Pillow JJ, Cheah F-C, Kramer BW, Newnham JP, Ikegami M, Jobe AH. IL-1 signaling mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by intra-amniotic LPS.Am J Respir Cell Mol Biol, In press.

Korfhagen TR, LeCras TD, Davidson C, Schmidt S, Ikegami M, Whitsett JA, Hardi WD. Rapamycin prevents transforming growth factor-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol, In press.

Ikegami M, Weaver TE, Grant SN, Whitsett JA. Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation. Am J Respir Cell Mol Biol, In press.

Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA. Deletion of SCAP in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem 2009;284:4018-30. PMID: 19074148

Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Effect of Ureaplasma colonization of amniotic fluid on the efficacy of antenatal corticosteroids for preterm lung maturation in sheep. Am J Obstet Gynecol 2009;200(1):96.e1-96.e6.

Polglase GR, Hillman N, Pillow JJ, Cheah F-C, Nitsos I, Moss TJM, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. J Ped Res 2008;64:517-22. PMID: 18596572

Wan H, Luo F, Wert SE, Zhang L, Xu Y, Ikegami M, Maeda Y, Whitsett JA. Kruppel-like Factor 5 is required for perinatal lung morphogenesis and function. Development 2008;135:2563-72. PMID: 18599506

Hardie WD, Davidson C, Ikegami M, Leikauf GD, LeCras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis. Am J Physiol 2008;294:L1217-25. PMID: 18424623

Kida H, Mucenski MM, Thitoff AR, Park K-S, Ikegami M, Muller W, Whitsett JA. Gp130-Stat3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 2008;172:1542-54. PMID: 18467707

Ikegami M, Falcone A, Whitsett JA. STAT-3 regulates surfactant phospholipid homeostasis during endotoxin mediated lung injury.J Appl Physiol 2008;104:1753-60. PMID: 18369093

Lin S, Ikegami M, Xu Y, Bosserhoff A-K, Malkinson AM, Shannon JM. Misexpression of MIA/CD-RAP disrupts lung morphogenesis and causes neonatal death.Dev Biol 2008;316:441-55. PMID: 18342301

Matsuzaki Y, Besnard V, Clark JC, Xu Y, Wert SE, Ikegami M, Whitsett JA. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol 2008;38:551-8. PMID: 18096869

McCurnin D, Seidner S, Chang L-Y, Waleh N, Ikegami M, Petershack J, Yoder B, Giavedoni L, Albertine KH, Dahl MJ, Wang Z-M, Clyman R. Ibuprofen-induced ductus arteriosis closure: effects on pulmonary mechanics, biochemistry, histology, and morphometry.Pediatrics 2008;121:945-56. PMID: 18450898

Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res 2008;63:388-93. PMID: 18356744

Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: Effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep.Am J Obstet Gynecol 2008;198:122.e1-8. PMID: 18166324

Xu Y, Ikegami M, Yanhua W, Matsuzaki Y, Whitsett JA. Gene expression and biological processes influenced by deletion of STAT3 in pulmonary type II epithelial cells. BMC Genomics 2007;8:455. PMID: 18070348

Ikegami M, Scoville EA, Grant S, Korfhagen T, Brondyk W, Scheule RK, Whitsett JA. Surfactant protein-D and surfactant inhibit endotoxin induced pulmonary inflammation.Chest 2007;132:1447-54. PMID: 17925426

Jobe AH, Moss TJM, Nitsos I, Ikegami M, Newnham JP. Betamethasone for lung maturation: Testing dose and formulation in fetal sheep. Am J Obstet Gynecol 2007;197:523.e1-6. PMID: 17980195

Hardie WD, Korfhagen TR, Sartor MA, Prestidge A, Medvedovic M, Le Cras TD, Ikegami M, Tomlinson CR, Nichols W, Wesselkamper SC, Whitsett JA, Leikauf GD. Genomic profile of matrix and vasculature remodeling in TGF-a-induced pulmonary fibrosis.Am J Resir Cell Mole Biol 2007;37:309-12. PMID: 17496152

Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. Perinatal increases in TGF-a disrupt the saccular phase of lung morphogenesis & cause remodeling: Microarray analysis.Am J Physiol 2007;293:L314-27. PMID: 17468132

Pillow JJ, Hillman N, Moss TJM, Polglase G, Bold G, Beaumont C, Ikegami M, Jobe AH. Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs.Am J Respir Crit Care Med 2007;176:63-9. PMID: 17431223

Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Wert SE, Neilson JR, Crabtree GR, Whitsett JA. Calcineurin/NFAT signaling is required for perinatal lung maturation and function.J Clin Invest 2006;116:2597-609.

Akei H, Whitsett JA, Buroker M, Ninomiya T, Tatsumi H, Weaver TE, Ikegami M. Surface tension influences cell shape and phagocytosis in alveolar macrophage.Am J Physiol 2006;291:L572-9.

Kingma PS, Zhang L, Ikegami M, Hartshorn K, McCormack FX, Whitsett JA. Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D.J Biol Chem 2006;281:24496-505.

Sosenko IRS, Kallapur SG, Nitsos I, Moss TJM, Newnham JP, Ikegami M, Jobe AH. IL-1a causes lung inflammation and maturation by direct effects on preterm fetal lamb lungs. Ped Res 2006;60:294-8.

Asikainen TM, Chang L-Y, Coalson JJ, Schneider BK, Walsh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, Gunzler V, White CW. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB Journal 2006;29:1698-1700.

Zhang L, Ikegami M, Korfhagen TR, McCormack F, Yoshida M, Senior RM, Shipley M, Shapiro SD, Whitsett JA. Neither SP-A nor the N-terminal domain of SP-A can substitute for SP-D in the regulation of alveolar homeostasis.Am J Physiol 2006;291:L181-90.

Matsuzaki Y, Xu Y, Ikegami M, Besnard V, Park K-S, Hull WM, Wert SE, Whitsett JA. Stat-3 is required for cytoprotection of the respiratory epithelium during adenoviral infection.J Immunology 2006;177:527-37.

Ikegami M, Carter K, Bishop K, Yadav A, Masterjohn E, Brondyk W, Scheule RK, Whitsett JA. Intratracheal recombinant surfactant protein-D prevents endotoxin shock in the newborn preterm lamb.Am J Respir Crit Care Med 2006;173:1342-7.

Martis PC, Whitsett JA, Xu Y, Wan H, Ikegami M. C/EBPa is required for lung maturation and function at birth.Development 2006;133:1155-64.