Pulmonary Biology

Stephan W. Glasser, PhD

Title

Associate Professor of Pediatrics

Appointment

Associate Professor, University of Cincinnati College of Medicine

Email

steve.glasser@chmcc.org

Phone

513-636-7850

Fax

513-636-7868

Credentials

PhD: University of Cincinnati, Developmental Biology,1988

Position History

Assistant Professor of Pediatrics, 1990-2000.

Associate Professor of Pediatrics, 2000-present.

Awards and Honors

New Investigator of the NIH Program of Excellence in Molecular Biology of the Heart and Lung, 1989

Research

Pulmonary surfactant protein C (SP-C) in lung innate defense; familial interstitial lung disease (ILD); deficiencies of SP-C; determining the mechanisms underlying the lung injury due to a lack of SP-C

Research Grants and Contracts

Role of Surfactant Protein-C and Innate Lung Defense. NIH-NHLBI 2 RO1 HL050046-15, Principal Investigator.

Regulation of Respiratory Epithelial Cell Homeostasis (PPG). Project 2: Modifier Genes of SP-C Induced Interstitial Lung Disease. NIH-NHLBI 2PO1 HL061646, Co-Investigator.

Publications, Most Recent

Glasser, S.W., Witt, T.L., Senft, A.P., Baatz, J.B., Folger, D., Maxfield, M.D., Prows, D.R., Korfhagen, T.R., and Whitsett J.A.: Surfactant Protein C deficient mice are susceptible to Respiratory Syncytial Virus infection. Am. J. Physiol. Lung Cell Mol. Biol. In press

Glasser, S.W., and Senft, A.P.: Pulmonary surfactant homeostasis and altered macrophage function. Lung Macrophages in health and chronic disease, Bentham Science Publishers Ltd., Sandra J. Hodge, editor. In press.

Hardie, W.D., Glasser, S.W., and Hagood, J.S.: Emerging concepts in the pathogenesis of lung fibrosis. Am. J. Pathology. In press.

Glasser, S.W., Senft, A.P., Whitsett, J.A., Maxfield, M.D., Richardson, T.R., and Korfhagen, T.R.: Macrophage dysfunction and susceptibility to Pseudomonas aeruginosa infection in surfactant protein-C deficient mice. J. Immunology. 181: 621-628, 2008.

S. W. Glasser and L. M. Nogee.: Genetically engineered mice in understanding the basis of neonatal lung disease. Seminars in Perinatology, 30: 341-349, 2006.

Glasser, S.W., Eszterhas, S.K., Detmer, E.A., Maxfield, M.D., Korfhagen, T.R.: The murine SP-C promoter directs type II cell-specific expression in transgenic mice. Am. J. Physiol. 288: L625-L632, 2005.

Lawson, W.E., Polosukhin, V.V., Stathopoulos, G.T., Zoia, O., Han, W., Lane, K.B., Li, B., Donnelly, E.F., Holburn, G.E., Lewis, K.G., Collins, R.D., Hull, W.M., Glasser, S.W., Whitsett, J.A. and Blackwell, T.S.: Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am. J. Pathol. 167:1267-1277, 2005.

Presentations, Most Recent

Lipid homeostasis is disrupted in Sftpc -/- mice. FASEB Summer Research Conference, Lung Surfactant: Cellular and Molecular Biology. Snowmass, Colorado, August 2006.

Invited co-moderator Session C25, Control of Lung Development, American Thoracic Society International Conference, May 2007.

Altered pulmonary lipid homeostasis is SP-C deficient mice. Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA. February 2007.

Pulmonary surfactant protein C deficiency and familial interstitial lung disease. Kentucky Pediatric Research Institute, University of Kentucky College of Medicine, Lexington, KY. February 2007.