Pulmonary Biology

Thomas R. Korfhagen, MD, PhD

Appointment

Professor of Pediatrics

Email

thomas.korfhagen@cchmc.org

Phone

513-636-8920

Credentials

BA Biology, University of Cincinnati, Cincinnati, OH, 1972

PhD Microbiology, University of Cincinnati, Cincinnati, OH, 1976

MD University of Cincinnati, Cincinnati, OH, 1981

Position History

8/87-8/94 Assistant Professor, Pediatrics, Children's Hospital, Cincinnati, OH
9/94-8/2000 Associate Professor with Tenure, Pediatrics, Children's Hospital, Cincinnati, OH
9/2000-present Professor with Tenure, Children's Hospital, Cincinnati, OH

Awards and Honors

BS awarded with Honors, 6/72
Elected to Alpha Omega Alpha Honor Medical Society, 11/80
Resident Teaching Award, 12/83
Abstracts selected for featured presentation, American Thoracic Society 1993, 1994, 1999, 2002

Publications, Most Recent

Zhang, L, Ikegami, M, Crouch, EC, Korfhagen, TR and Whitsett, JA: Activity of pulmonary surfactant protein D (SP-D) in vivo is dependent on oligomeric structure.J. Biol. Chem. 276:19214-19219, 2001.

Hardie, WD, Piljan-Gentle, A, Dunlavy, M, Ikegami, M and Korfhagen, TR: Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-α.Am. J. Physiol. 281:L1088-L1094, 2001.

Ikegami, M, Elhalwagi, BM, Palaniyar, N, Dienger, K, Korfhagen, T, Whitsett, JA and McCormack, FX: The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse.J. Biol. Chem. 276:38542-38548, 2001.

Hardie, WD, Prows, DR, Piljan-Gentle, A, Dunlavy, MR, Wesselkamper, SC, Leikauf, GD and Korfhagen, TR: Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-α.Am. J. Respir. Cell Mol. Biol. 26:430-437, 2002.

LeVine, AM, Hartshorn, K, Elliott, J, Whitsett, J and Korfhagen, T: Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection.Am. J. Physiol. 282:L563-L572, 2002.

Palaniyar, N, Zhang, L, Kuzmenko, A, Ikegami, M, Wan, S, Wu, H, Korfhagen, TR, Whitsett, JA and McCormack, FX: The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo.J. Biol. Chem., 277:26971-26979, 2002.

Quintero, OA, Korfhagen, TR and Wright, JR: Surfactant protein A regulates surfactant phospholipid clearance after LPS-induced injury in vivo.Am. J. Physiol. 283:L76-L85, 2002.

Le Cras, TD, Hardie, WD, Fagan, K, Whitsett, JA, Korfhagen, TR: Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing TGF-α.Am. J. Physiol. 285:L1046-L1054, 2004.