Vladimir V. Kalinichenko, MD, PhD
Title
Associate Professor of Pediatrics in the Division of Pulmonary Biology
Appointment
Associate Professor
Email
Vladimir.Kalinichenko@cchmc.org
Phone
513-636-4822
Fax
513-636-7868
Credentials
MD: Medicine, Russian State Medical University, Moscow, Russia, 1993
PhD: Immunology, Russian State Medical University, Moscow, Russia, 1995
Postdoctoral: Molecular Immunology,
University of Illinois at Chicago, Center for Molecular Biology, IL, 2000
Postdoctoral: Developmental Biology and Molecular Genetics, University of Illinois at Chicago, Department of Molecular Genetics, IL, 2002
Awards and Honors
Fellowship from European Soros Foundation, 1995
Research Assistant Professor, Dept. of Molecular Genetics, University of Illinois, Chicago, 2002-2004
Ruth Kirschstein National Research Service Award from NIH (Lung Biology and Pathology), 2003-2004
Scientist Development Award from American Heart Association (National office), 2003–2007
Assistant Professor of Medicine (tenure-track), Section of Pulmonary and Critical Care Medicine, Department of Medicine, Pritzker School of Medicine, the University of Chicago, 2004–2007
Member of Committee on Developmental Biology, the University of Chicago, 2004-2007
Research
Dr. Kalinichenko's laboratory is investigating the transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis. The primary emphasis of the studies is on the Winged helix/Forkhead Box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival. The ultimate goal of the research program is to identify, and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation.
Research Grants and Contracts
National Institutes of Health /NHLBI ROI - Research Grant: Fox Transcription Factors in Development of Pulmonary Capillaries; 07/01/06-06/31/11, Principal Investigator
American Cancer Society, National Office, Research Scholar Grant: Foxm1 Transcription Factor in Development of Non-small cell Lung Cancer; 07/01/06 - 06/31/10, Principal Investigator
March of Dimes Birth Defects Foundation Research Grant: Role of Foxf1 transcription factor in lung morphogenesis; 07/1/05- 06/30/08, Principal Investigator
Publications, Most Recent
Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Qin Y, Malik AB, Costa RH, Kalinichenko VV. Myocardium Defects and Ventricular Hypoplasia in Mice Homozygous Null for the Forkhead Box M1 Transcription Factor.Developmental Dynamics 2007;236(4):1000-13.
Malin D, Kim I-M, Boetticher E, Kalin TV, Ramakrishna S, Meliton L, Ustiyan V, Zhu X, Kalinichenko VV. Forkhead Box F1 Is Essential for Migration of Mesenchymal Cells and Directly Induces Integrin-Beta3 Expression.Molecular and Cellular Biology 2007;27(7):2486-98.
Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, Costa RH. A Cell Penetrating ARF Peptide Inhibitor of the Foxm1 Transcription Factor Is an Effective Treatment for Hepatocellular Carcinoma In Vivo.J Clinical Investigation 2007;117(1):99-111.
Zhao YY, Gao X, Vogel S, Kalinichenko VV, Wang IC, Costa RH, Malik AB. Forkhead Transcription Factor FoxM1 Regulates Endothelial Proliferation and Vascular Re-annealing Following Injury Induced by LPS.J Clinical Investigation 2006;116(9):2333-43.
Kim I-M, Ackerson T, Ramakrishna S, Tretiakova M, Wang IC, Kalin TV, Major ML, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV. The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer.CancerResearch 2006;66(4):2153-61.
Kalin TV, Wang IC, Ackerson TJ, Major ML, Detrisac CJ, Kalinichenko VV, Lyubimov A, Costa RH. Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice.Cancer Research 2006;66(3):1712-20.
Costa RH, Kalinichenko VV, Tan Y, Wang IC. The CAR nuclear receptor and hepatocyte proliferation.Hepatology 2005;42:1004-8.
Kim I-M, Zhou Y, Ramakrishna S, Hughes DE, Solway J, Costa RH, Kalinichenko V. Functional Characterization of Evolutionary Con served DNA Reg ions in Forkhead Box f1Gene Locus.J Biological Chemistry 2005;280:37908-16.
Professional Organization Memberships
