Le Cras Lab Research Publications: Representative Examples
These publications are representative of the research being done in the Le Cras lab. The linked text will take you to the journal's abstract of the article. The PDF icons are linked to a PDF of the article available on a Journal's site. Depending on the Journal's publishing policy, you may need a subscription to download the PDF.
E. L. Kramer, G. H. Deutsch, M. Sartor, M. Ikegami, W. D. Hardie, T. R. Korfhagen, and T. D. Le Cras. (2007) Perinatal induction of TGF-a disrupts the saccular phase of lung morphogenesis and causes remodeling: Microarray analysis. Am. J. Physiol. (Lung Cell Mol. Physiol.). 293:L314-L327
T.D. Le Cras, L.G. Fernandez, and V.E. Laubach. (2005) Vascular growth and remodeling in compensatory lung growth following right pneumonectomy. J. Appl. Physiol. 98:1140-1148
Editorial on Le Cras Lab publications: D. Massaro and G. DeCarlo Massaro. (2004) Critical period for alveologenesis and early determinants of adult pulmonary disease. Am J Physiol Lung Cell Mol Physiol 287: L715-L717
T. D. Le Cras, W. D. Hardie, J. A. Whitsett, and T. R. Korfhagen. (2004) Transient induction of TGF-a disrupts lung morphogenesis, causing pulmonary disease in adulthood. Am. J. Physiol. (Lung Cell Mol. Physiol. 287: L718-L729
T. D. Le Cras, R.E. Spitzmiller, J.M. Greenberg, J. A. Whitsett, and L. Akeson. (2004) VEGF causes pulmonary hemorrhage, hemosiderosis, and airspace enlargement in neonatal mice. Am. J. Physiol. (Lung Cell Mol. Physiol. 287: L134-142)
T. D. Le Cras, N. Markham, R. Tuder, N. F. Voelkel, and S. H. Abman. (2002) Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am. J. Physiol. (Lung Cell Mol. Physiol.) 283: L555-L562
T. D. Le Cras and I. F. McMurtry. Nitric oxide production in the hypoxic lung. (2001) Am. J. Physiol. (Lung Cell Mol. Physiol.) 280:L575-L582
T. D. Le Cras, D. Kim, N. E. Markham, and S. H. Abman. (2000) Early abnormalities in pulmonary vascular development in the Fawn-Hooded rat raised at altitude. Am. J. Physiol. (Lung Cell Mol. Physiol.) 279:L283-291
T. D. Le Cras, N. E. Markham, K. G. Morris, C. R. Ahrens, I. F. McMurtry, and S. H. Abman. (2000) Neonatal dexamethasone treatment increases the risk for development of pulmonary hypertension in adult rats. Am. J. Physiol. (Lung Cell Mol. Physiol.) 278 (4): L822-830
T. D. Le Cras, D. Kim, S. Gebb, N. E. Markham, J. M. Shannon, R. M. Ruder, and S. H. Abman. (1999) Abnormal lung growth and the development of pulmonary hypertension in the fawn-hooded rat. Am. J. Physiol. (Lung Cell Mol. Physiol.) 277: L709-718.
Contact information
Tim D. Le Cras PhD
Associate Professor of Pediatrics
Division of Pulmonary Biology
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave., Cincinnati, Ohio 45229-3039
Phone 513-636-8151
Fax 513-636-7868
Email tim.lecras@cchmc.org
