Research Area: Lung Diseases
Lung diseases can be congenital or acquired after birth. Many lung diseases are life-threatening, or lead to chronic morbidity (debility). Millions of people in the United States and world-wide are affected by lung disease of one kind or another. Life-saving surfactant therapy for respiratory distress syndrome (RDS), which occurs in infants born prematurely, was developed at Cincinnati Children’s by Dr. Whitsett. This therapy alone has resulted in a major reduction in perinatal deaths in the United States and countries world-wide. In a similar manner, groups in our division are actively seeking new treatments and therapies for many other lung diseases that affect children and adults. Using a wealth of cutting-edge approaches (many of which have been developed in our division) our groups work on the pathogenesis (causes) of lung diseases with the goal of identifying new therapeutic targets.
Some of the lung diseases being studied in the Division of Pulmonary Biology include:
| Respiratory Distress Syndrome (RDS) |
| Stephan Glasser, PhD |
SP-C in innate defense, interstitial lung disease and injury |
| Machiko Ikegami, MD, PhD |
New treatment for RDS, ventilatory lung injury |
| Alan Jobe, MD, PhD |
See Division of Perinatal Biology. |
| Vladimir Kalinichenko, MD, PhD |
Fox proteins in lung development and carcinogenesis |
| Suhas Kallapur, MD |
See Division of Perinatal Biology. |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| Ward Rice, MD, PhD |
Molecular and cellular mechanisms regulating surfactant processing |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Yan Xu, PhD |
Bioinformatics, systems biology of lung development and disease |
| Bronchopulmonary Dysplasia (BPD) |
|
Lung histology shows thickening of alveolar septae, enlarged distal airspaces and inflammation in infant with bronchopulmonary dysplasia (BPD).
|
| Ann Akeson, PhD |
Lung vasculogenesis, endothelial lineage selection, and lymphatics |
| Machiko Ikegami, MD, PhD |
SP-D containing surfactant for treatment |
| Alan Jobe, MD, PhD |
See Division of Perinatal Biology. |
| Suhas Kallapur, MD |
See Division of Perinatal Biology. |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| Ward Rice, MD, PhD |
Molecular and cellular mechanisms regulating surfactant processing |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Pulmonary Fibrosis |
| Stephan Glasser, PhD |
SP-C in innate defense, interstitial lung disease and injury |
| William Hardie, MD |
See Division of Pulmonary Medicine. |
| Machiko Ikegami, MD, PhD |
Altered lung mechanics and surfactant metabolism |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Interstitial Lung Disease (ILD) |
| Stephan Glasser, PhD |
SP-C in innate defense, interstitial lung disease and injury |
| Machiko Ikegami, MD, PhD |
Lung mechanics and surfactant function |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Yan Xu, PhD |
Bioinformatics, systems biology of lung development and disease |
| Acute Respiratory Distress Syndrome (ARDS) in Adults |
| Machiko Ikegami, MD, PhD |
Molecular mechanisms of surfactant homeostasis in the injured lung |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Pulmonary Vascular Diseases |
|
Lung histology shows thickening and remodeling of small pulmonary artery in a patient with pulmonary arterial hypertension (PAH). |
| Ann Akeson, PhD |
Lung vasculogenesis, endothelial lineage selection, and lymphatics |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| Timothy Le Cras, PhD |
Lung development, pathogenesis of lung remodeling |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Lung Infection, Injury and Remodeling |
| Ann Akeson, PhD |
Lung vasculogenesis, endothelial lineage selection, and lymphatics |
| Cindy Bachurski, PhD |
Transcriptional control/interactions development and injury/repair |
| Stephan Glasser, PhD |
SP-C in innate defense, interstitial lung disease and injury |
| Machiko Ikegami, MD, PhD |
SP-D, Stat-3, C/EBPα in lung injury/repair |
| Vladimir Kalinichenko, MD, PhD |
Fox proteins in lung development and carcinogenesis |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| Timothy Le Cras, PhD |
Lung development, pathogenesis of lung remodeling |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Susan Wert, PhD |
Pathology developing lung, injury / repair and surfactant dysfunction |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Kathryn Wikenheiser-Brokamp, MD, PhD |
Epithelial cell growth regulation, pathways in lung cancer |
| Pulmonary Alveolar Proteinosis (PAP) |
| Machiko Ikegami, MD, PhD |
Surfactant catabolism |
| Bruce Trapnell, MD |
Regulation innate immunity, inflammation, GM-CSF in lung disease |
| Susan Wert, PhD |
Pathology developing lung, injury / repair and surfactant dysfunctionPathology developing lung, injury / repair and surfactant dysfunction |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Pulmonary Surfactant Disorders |
| Cindy Bachurski, PhD |
Transcriptional control/interactions development and injury/repair |
| Stephan Glasser, PhD |
SP-C in innate defense, interstitial lung disease and injury |
| Machiko Ikegami, MD, PhD |
Molecular mechanisms of surfactant homeostasis |
| Paul Kingma, MD, PhD |
SP-D in neonatal sepsis, RDS and innate immune system in neonatal infection |
| Thomas Korfhagen, MD, PhD |
Surfactant proteins, lung infection, inflammation, and injury/repair |
| Ward Rice, MD, PhD |
Molecular and cellular mechanisms regulating surfactant processing |
| John Shannon, PhD |
Lung morphogenesis and differentiation, and FGFs |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Susan Wert, PhD |
Pathology developing lung, injury / repair and surfactant dysfunctionPathology developing lung, injury / repair and surfactant dysfunction |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Asthma |
|
Histology shows inflammatory cells around an artery and airway in a mouse model of allergic asthma. (Picture courtesy of the Le Cras laboratory.) |
| Machiko Ikegami, MD, PhD |
C/EBPα, airway resistance |
| Vladimir Kalinichenko, MD, PhD |
Fox proteins in lung development and carcinogenesis |
| Timothy Le Cras, PhD |
Lung development, pathogenesis of lung remodeling |
| Susan Wert, PhD |
Pathology developing lung, injury / repair and surfactant dysfunctionPathology developing lung, injury / repair and surfactant dysfunction |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Yan Xu, PhD |
Bioinformatics, systems biology of lung development and disease |
| Lung Cancer |
|
Histology shows multiple tumors in a genetic mouse model of lung cancer. (Picture courtesy of the Wikenhesier-Brokamp laboratory.) |
| Machiko Ikegami, MD, PhD |
C/EBPα in lung cancer |
| Tanya Kalin, MD, PhD |
Regulation of DNA replication and mitosis in lung and prostate tumor cells |
| Vladimir Kalinichenko, MD, PhD |
Fox proteins in lung development and carcinogenesis |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Kathryn Wikenheiser-Brokamp, MD, PhD |
Epithelial cell growth regulation, pathways in lung cancer |
| Yan Xu, PhD |
Bioinformatics, systems biology of lung development and disease |
| Cystic Fibrosis (CF) |
| Paul Kingma, MD, PhD |
SP-D in neonatal sepsis, RDS and innate immune system in neonatal infection |
| Susan Wert, PhD |
Pathology developing lung, injury / repair and surfactant dysfunctionPathology developing lung, injury / repair and surfactant dysfunction |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Yan Xu, PhD |
Bioinformatics, systems biology of lung development and disease |
| Rare Lung Diseases |
| Paul Kingma, MD, PhD |
SP-D in neonatal sepsis, RDS and innate immune system in neonatal infection |
| Lisa Young, MD |
See Division of Pulmonary Medicine. |
| Frank McCormack, MD |
See Division of Pulmonary, Critical Care and Sleep Medicine at the University of Cincinnati. |
| Bruce Trapnell, MD |
Regulation innate immunity, inflammation, GM-CSF in lung disease |
| Timothy Weaver, PhD |
Cytoprotective pathways, epithelium adaptation to stress, surfactant |
| Susan Wert, PhD |
Pathology developing lung, injury / repair and surfactant dysfunctionPathology developing lung, injury / repair and surfactant dysfunction |
| Jeffrey Whitsett, MD |
Lung transcriptional control, epithelial patterning and differentiation |
| Yan Xu, PhD |
Bioinformatics, systems biology of lung development and disease |
