Overview
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Anne-Karina Perl, PhD
Assistant Professor of Pediatrics
Division of Pulmonary Biology
MLC 7029, 3333 Burnet Avenue
Cincinnati Children's Hospital Medical Center
Cincinnati, OH 45229
Phone: 513-636-6084 | Fax: 513-636-7868
anne.perl@cchmc.org |
The molecular mechanisms underlying normal lung formation provide a framework for understanding processes leading to lung malformation and lung repair processes in the preterm and postnatal lung. Lung development is determined by the action of numerous genes that influence branching, proliferation, cell commitment, and differentiation.
There are many signaling pathways involved in the regulation of lung formation and we are beginning to understand the molecular network governing lung development. The fibroblast growth factor signaling pathway (FGF/FGFR) is critical to the process of branching, cellular differentiation and proliferation in the developing lung. Data from our laboratory supports the hypothesis of the existence of distinct subsets of endodermaly derived progenitor cells during lung development. Our long-term goal is to understand the characteristics and the fate of these lung progenitors for prevention and therapy of lung disease.
Learn more about Anne-Karina Perl, PhD, and her lab from her research topics and selected publications.
