William D. Hardie, MD
Appointment
Associate Professor, Pulmonary Medicine, University of Cincinnati College of Medicine
Email
william.hardie@chmcc.org
Phone
513-636-6771
Fax
513-636-4615
Credentials
MD: Vanderbilt University, Nashville, Tenn., 1990.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio.
Fellowship: Pediatric Pulmonary, Children's Hospital Medical Center, Cincinnati, Ohio.
Certification: Pediatrics, 1993; Pulmonary Medicine, 1999.
Position History
1988-89 American Heart Association Medical Student Research Fellowship. Department of Pulmonary Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
1990-93 Internship and Residency - Cincinnati Children's Hospital Medical Center
1993-96 Pediatric Pulmonary Fellowship - Cincinnati Children's Hospital Medical Center
1996-1998 Instructor, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center
1997-present Director, Pulmonary Function Laboratory, Cincinnati Children's Hospital Medical Center
1998 - 2003 Assistant Professor of Clinical Pediatrics, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center
2003-present Associate Professor of Clinical Pediatrics, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center
Awards and Honors
- 1989 Alpha Omega Alpha Research Award
- 1992 Resident Teaching Award
- 1993 Samuel Dalinsky Award ("Outstanding Graduating Resident")
- 2000 Mead Johnson Excellence in Teaching Commendation Recipient
- 2000 Mead Johnson Excellence in Teaching Award
- 2008 Best Doctors in America
Research
Growth factors in lung remodeling
Research Grants and Contracts
NIH/NHLBI, "Growth Factor Protection in Acute Lung Injury,” 12/15/05 - 11/30/09, Co-Investigator.
NIH/NIEHS, “Functional Genomics of Chemical-Induced Acute Lung Injury,” 09/29/06 - 05/31/11, Co-Investigator.
NIH/NHLBI, "The Role of Placenta Growth Factor in Sickle Acute Chest Syndrome," 7/1/05 - 6/31/09, Co-Investigator.
NIH/NHLBI, “Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis,” 04/1/2007 – 03/31/12, Principal Investigator.
Publications, Most Recent
Ikegami M, Le Cras TD, Hardie WD, Stahlman M, Whitsett JA, Korfhagen TR. Transforming Growth Factor Perturbs Surfactant Homeostasis In Vivo. Am J Physiol Lung Cell Mol Physiol. 289: L34-43, 2005.
Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, Leikauf GD. Genomic Profile of Matrix and Vasculature Remodeling in TGF {alpha}-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 37: 309-21, 2007.
Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. Perinatal Increases in TGF-{alpha} Disrupt the Saccular Phase of Lung Morphogenesis & Cause Remodeling: Microarray Analysis. Am J Physiol Lung Cell Mol Physiol. 293: L314-327, 2007.
McPhail GL and Hardie WD. Cavitary Lung Lesions in a 2-Year-Old Child. Respiration 76:117-118, 2008
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Crit Care Med 38(4): 446-54, 2008.
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR.EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-{alpha}-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 294(6):L1217-25, 2008.
Special Interests
Pulmonary function tests; pneumonia; empyema
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
