Radiology

Scott K. Holland, PhD

Title

McLaurin Scholar

Appointment

Professor of Radiology, Pediatrics and Physics

Email

scott.holland@cchmc.org

Phone

513-636-7565

Fax

513-636-0434

Bio

Scott K. Holland, PhD, is the McLaurin Scholar in Pediatric Neurosurgery and Professor of Radiology, Pediatrics, Biomedical Engineering, Neuroscience and Physics at University of Cincinnati, and Director of the Pediatric Brain Imaging Research Center at Children's Hospital Research Foundation. A physicist by training, he received his BS degree (1980) in Physics from Muhlenberg College, Allentown, PA. and MS (1982) and PhD (1985) degrees in Applied Physics from Yale University.

Credentials

PhD: Engineering and Applied Science, Yale University, 1985
MPhil: Engineering & Applied Science, Yale University, 1983
MS: Engineering & Applied Science, Yale University,1982
BS: Physics (Magna Cum Laude), Muhlenberg College, 1980

Awards and Honors

**2006 "Editor's Choice" award for Neuroimage: Cognitive Neuroscience section for paper entitled: "Functional MRI evidence for disparate developmental processes underlying intelligence in boys and girls." Schmithorst, V.J. and Holland, S.K.,. Neuroimage, 31:1366-79, 2006.
**2006 Top 5 % of program worthy of mention. "A Longitudinal fMRI Study of Language Development in Children". 58th Annual Meeting of the American Academy of Neurology, San Diego, CA, April, 2006
J. P. Szaflarski, V. J. Schmithorst, M. Altaye, A. W. Byars, J. Ret, E. Plante and S. K. Holland
*2005 Medical Student Essay Award, American Academy of Neurology: Jan-Mendelt Tillema, "Functional MRI shows right hemispheric dominance in language processing following perinatal left MCA stroke". AAN Annual Meeting, San Diego, CA, 2005. Medical Student under mentorship.
*2002 – Graduate Student Travel Award, Southern Society for Psychology, Nashville, TN, 2002.
"fMRI Data from Saccade Sequencing Tasks of Increasing Complexity".
Awarded to Anthony Landreth, B.A., Graduate student under mentorship
*2001 - Resident Travel Award, Middle Section, Triologial Society
"Functional Magnetic Resonance Imaging of the Pediatric Swallow: Imaging the Cortex and the Brainstem." January 21, 2001. Chicago, IL Awarded to Christopher Hartnick, MD, Clinical Fellow under mentorship
*1999 - John A. Kirkpatrick Young Investigator Award for Paper presentation at the 42nd Annual Meeting of The Society for Pediatric Radiology, May 14-17, 1999, Vancouver, British Columbia, Canada. Awarded to Raymond Sze, MD, Clinical Fellow under mentorship
1998 – Derek Harwood-Nash Award for best paper in Pediatric Neuroradiology presented at the 36th annual meeting of the Am. Soc. Neuroradiology, Philadelphia, April 1998
1998 – Session Moderator: fMRI Pot Pourri, 6th Annual meeting of the International Society of Magnetic Resonance in Medicine, Sydney Australia.
1991 - American Association of Physicists in Medicine/IPSM Medical Physics Travel Award. Awarded annually to a U.S. Medical Physicist for 3 weeks of travel and lectures in the U.K.
1991 - Moore Fund Award - Yale College Curriculum Development Award
For upgrade ME286 - Mechanical Engineering Laboratory Course Curriculum
$4,255 for student stipend, hardware and software development for teaching lab.
1990 - Society of Magnetic Resonance Imaging - Cum Laude Award for Spectroscopy
Poster Presentation at 8th Annual Meeting, Washington D.C. 1990
19F NMR of Fluosol for Real-Time, In Vivo Studies of Rat Liver Oxygenation.

* indicates recipient was a graduate student, post-doc, or clinical fellow under my mentorship

Research

Neuroimaging applications of MRI in pediatrics; functional MRI of language, hearing and neuroplasticity following brain injuryl; studies in small animals and the use of a 7 Tesla small animal MRI system for micro imaging in mouse and rat models brain development and brain injury

Research Grants and Contracts

NIH RO1–HD38578-06, fMRI Evidence of Language Reorganization in Children, 2/1/00 - 2/28/11, PI.

NIH-RO1 – DC007186, fMRI, Genes and Outcome of Cochlear Implants in Infants, 12/1/04 - 11/31/09, PI.

HRSA-C76 HF 00768-01, Functional and Physiological Brain Imaging in Children, 2/1/03 - 12/30/08, PI.

NIH-S10 RR17211-01, High End Instrumentation - 7T MRI Scanner for Small Animals/Developmental Disorders, 10/1/02 - 12/31/06, PI.

R21 MH68267-01, Application of the STAP algorithm to fMRI data, 5/1/04 - 4/31/07, PI.

NIH-PO1–ES011261-01, Study of Prevalent Neurotoxicants in Children, 9/1/01 - 8/31/06.

NIH- K25-DC008110, Cortical Reorganization in Children with Unilateral Sensorineural Hearing Loss, 5/1/05 - 4/30/11.

NIH-K23 NS052468-01, EEG-fMRI in patients with JME, 6/1/06 - 5/31/011.

NIH-2T32NS007453-06, Training Program in the Neurosciences, 2000 - 2010.

NIH-1 T32 EB01656-01, Neuroimaging Training in Pediatrics and Brain Development, 9/20/03 - 6/30/08.

NIH-K23 HD/NS01467-01, Functional Language Organization in Childhood Stroke, 2/1/02 - 1/31/07.

NIH-1 K23 MH64086-01A1, Memory-induced brain activation in bipolar patients, using fMRI, 12/1/02 - 11/31/07.

Publications, Most Recent

*Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J., Solodkin, A., Chen, E.E., Szaflarski, J.P. and Plante, E., "Age Related Connectivity Changes in fMRI Data from Children Listening to Stories."Neuroimage, 34:349-60, 2007.

**Szaflarski, J.P., Schmithorst, V.J., Altaye, M., Byars, A.W., Ret, J., Plante, E. and Holland, S.K., "A longitudinal functional magnetic resonance imaging study of language development in children 5 to 11 years old."Ann Neurol, 59:796-807, 2006.

*Adhami, F., Liao, G., Schloemer, A., Morozov, Y.M., Schmithrost, V.J., Lorenz, J.N., Dunn, R.S., Vorhees, C.V., Wills-Karp, M., Davis, R.J., Rakic, P., Dardzinski, B.J., Holland, S.K., Sharp, F.R. and Kuan, C.Y., "Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy."American Journal of Pathology, 169:566-83, 2006.

*Jacola, L.M., Schapiro, M.B., Schmithorst, V.J., Byars, A.W., Strawsburg, R.H., Szaflarski, J.P., Plante, E. and Holland, S.K., "Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke."Neuropediatrics, 37:46-52, 2006.

**Szaflarski, J.P., Holland, S.K., Schmithorst, V.J. and Byars, A.W., "fMRI study of language lateralization in children and adults."Hum Brain Mapp, 27:202-12, 2006.

*Yuan, W., Szaflarski, J.P., Schmithorst, V.J., Schapiro, M., Byars, A.W., Strawsburg, R.H. and Holland, S.K., "fMRI shows atypical language lateralization in pediatric epilepsy patients."Epilepsia, 47:593-600, 2006.

Adler, C.M., *Adams, J., DelBello, M.P., Holland, S.K., V.J., S., Levine, A., Jarvis, K. and Strakowski, S.M., "Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: A diffusion tensor imaging study."American Journal of Psychiatry, 163:322-4, 2006.

Chiu, C.-Y.P., Schmithorst, V.J., Brown, R.D., Holland, S.K. and Dunn, R.S., "Making memories: A cross-sectional investigation of episodic memory encoding in children using fMRI."Developmental Neuropsychology, 29:321–40, 2006.

Plante, E., Holland, S.K. and Schmithorst, V.J., "Prosodic processing by children: An fMRI study."Brain Lang, 97:332-42, 2006.

Plante, E., Schmithorst, V.J., Holland, S.K. and Byars, A.W., "Sex Differences in the Activation of Language Cortex During Childhood."Neuropsychologia, 44:1210-21, 2006.

Schmithorst, V.J. and Holland, S.K., "Functional MRI Evidence for Disparate Developmental Processes Underlying Intelligence in Boys and Girls,"Neuroimage, 31:1366-79, 2006.

Schmithorst, V.J., Plante, E. and Holland, S.K., "Cognitive Modules Utilized for Narrative Comprehension in Children: A Functional Magnetic Resonance Imaging Study."Neuroimage, 26:254-66, 2006.

Chiu, C.-Y.P., Coen-Cummings, M., Schmithorst, V.J., Holland, S.K., Nabors, L., Keith, R., Kramer, M. and Rozier, H., "Sound blending in the brain: An fMRI investigation."Neuroreport, 16:883-6, 2005.

Schmithorst, V.J., Holland, S.K., Ret, J., Duggins, A., Arjmand, E. and Greinwald, J., "Cortical reorganization in children with unilateral sensorineural hearing loss."Neuroreport, 16:463-7, 2005.

Schmithorst, V.J., Wilke, M., Dardzinski, B.J. and Holland, S.K., "Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study."Hum Brain Mapp, 26:139-47, 2005.

Strakowski, S.M., Adler, C.M., Holland, S.K., Mills, N.B., DelBello, M.P. and Eliassen, J.C., "Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task."American Journal of Psychiatry, 62:1697-705, 2005.

Adler, C.M., DelBello, M.P., Mills, N.P., Schmithorst, V.J., Holland, S.K. and Strakowski, S.M., "Comorbid ADHD is Associated with Altered Patterns of Neuronal Activation in Adolescents with Bipolar Disorder Performing a Simple Attention Task." Bipolar Disorders, 7:577-88, 2005.

*Wilke, M., Kowatch, R.A., DelBello, M.P., Mills, N.P. and Holland, S.K., "Voxel-based Morphometry in Adolescents with Bipolar Disorder: First Results."Psychiatry Research: Neuroimaging, 131:57-69, 2004.

*Zur, K.B., Holland, S.K., *Yuan, W. and Choo, D.I., "Functional magnetic resonance imaging: contemporary and future use."Curr Opin Otolaryngol Head Neck Surg, 12:374-7, 2004.

Adler, C.M., Holland, S.K., Schmithorst, V.J., Wilke, M., Weiss, K.L., Pan, H. and Strakowski, S.M., "Abnormal frontal white matter tracts in bipolar disorder: A diffusion tensor imaging study."Bipolar Disorders, 6:167-203, 2004.

Chiu, C.-Y.P., V.J., S., Holland, S.K. and Choo, D.I., "Event-related fMRI Study of Recognition of Simulated CI Speech."International Congress Series, 1273:391-3, 2004.

Holland, S.K., Choo, D.I., Ret, J.K., Hilbert, L., Dunn, R.S. and Schmithorst, V.J., "fMRI of Severe to Profoundly Hearing Impaired Infants and Toddlers Under Sedation."International Congress Series, 1273:383-6, 2004.

Schapiro, M.B., Schmithorst, V.J., Wilke, M., Byars, A.W., Strawsburg, R.H. and Holland, S.K., "BOLD-fMRI signal increases with age in selected brain regions in children."NeuroReport, 15:2575-8, 2004.

Schmithorst, V.J. and Holland, S.K., "Comparison of three methods for generating group statistical inferences from independent component analysis of functional magnetic resonance imaging data."J Magn Reson Imaging, 19:365-8, 2004.

Schmithorst, V.J. and Holland, S.K., "Event-related fMRI technique for auditory processing with hemodynamics unrelated to acoustic gradient noise."Magn Reson Med, 51:399-402, 2004.

Schmithorst, V.J. and Holland, S.K., "The effect of musical training on the neural correlates of math processing: a functional magnetic resonance imaging study in humans." Neurosci Lett, 354:193-6, 2004.

Strakowski, S.M., Adler, C.M., Holland, S.K., Mills, N. and DelBello, M.P., "A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder."NeuroPyschoPharmacology, 29:1734-40, 2004.

Szaflarski, J.P., Holland, S.K., Schmithorst, V.J. and Dunn, R.S., "High-resolution fMRI at 3T in healthy and epilepsy subjects: hippocampal activation with picture encoding task."Epilepsy and Behavior, 5:244-52, 2004.

* indicates first author was a graduate student, post-doc, or clinical fellow under my mentorship
** indicates first author is a junior faculty member with an NIH K-award on which I am serving as primary mento

Presentations, Most Recent

*Kaimal, V., Holland, S.K., Schmithorst, V.J. and Qi, X., "MR Detection of Tumor Cells Labeled with USPIO using DOPS Liposomes." ISMRM 14th Scientific Meeting, Seattle, WA, 2006.

*Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J., Solodkin, A., Altaye, M. and Plante, E., "Functional connectivity among cognitive modules utilized for narrative story comprehension." 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

*Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J., Solodkin, A. and Plante, E., "Age related connectivity changes in fMRI data from children performing a narrative story comprehension task." 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

*DiFrancesco, M.W., Yuan, W.H., Pratt, W.H. and Holland, S.K., "Comparison of Contrast-to-Noise Ratio for in vivo Mouse Brain Imaging at 3T and 7T under Nearly Identical Scanner Configurations." ISMRM 14th Scientific Meeting, Seattle, WA, 2006.

Holland, S.K., Choo, D.I., Schmithorst, V.J., Altaye, M., Karunanayaka, P., Patel, A., Brown, D., Eads, E., Hilbert, L. and Cahill, L., "Auditory Activation in Sedated Hearing Impaired Infants." 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

Holland, S.K., Choo, D.I., Schmithorst, V.J., Altaye, M., Karunanayaka, P.R., Patel, A., Brown, D., Eads, E., Hilbert, L. and Cahill, L., "Can fMRI Predict Outcome for Cochlear Implantation in Children?" 9TH Intl' Conf. on Cochlear Implants, Vienna, Austria, 2006.

Jacola, L.M., Schapiro, M., Patterson, B., Hickey, F., Chalfonte-Evans, M., Schmithorst, V.J., Byars, A.W., S., H. and S.K., H., "FMRI reveals altered patterns of brain activation during language processing in persons with Down syndrome. In: Organization for Human Brain Mapping." 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

Jacola, L.M., Schapiro, M.B., Patterson, B., Hickey, F., Chalfonte-Evans, M., Schmithorst, V.j., Byars, A.W., Hotze, S. and Holland, S.K., "FMRI reveals altered patterns of brain activation during language processing in persons with Down syndrome." 9th World Downs Syndrome Congess, Vancouver, BC, 2006.

*Karunanayaka, P., Holland, S.K., Schmithorst, V.J., Solodkin, A. and Plante, E., "Age Related Connectivity Changes in fMRI Data from Children Listening to Stories." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J., DiFrancesco, M., Dardzinski, B.J. and Holland, S.K., "Sex Differences in White Matter Diffusion Anisotropy in the Normal Pediatric Population." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J. and Holland, S.K., "Differences between Boys and Girls in the Correlation of Functional Brain Connectivity and Intelligence." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J. and Holland, S.K., "The development of functional and effective connectivity for narrative processing in children investigated via functional MRI and Multivariate Autoregressive Modeling." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J. and Holland, S.K., "A Data-Driven Method for Analysis of Associated Time Courses Found from Group Independent Component Analysis." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J., Holland, S.K. and Plante, V.J., "Object Identification and Lexical / Semantic Access in Children: A Functional Magnetic Resonance Imaging Study of Word-Picture Matching." 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

*Karunanayaka, P., Solodkin, A., Plante, E., Schmithorst, V.J., Szaflarski, J.P. and Holland, S.K., "A Computational Model for Language in Developing Brain Derived from fMRI Data." 3rd. Cincinnati Translational Neuroscience Symposium, Cincinnati, 2005.

*Kramer, M., Chiu, C.-Y., P., , Schmithorst, V.J., Brown, R.D. and Holland, S.K., "Neural Correlates of Verbal Encoding Strategies." International Neuropsych Society, Boston, 2005.

*Yuan, W.H., Holland, S.K., Cecil, K.M., Wessel, S., Dietrich, K. and Ris, D., "The impact of childhood lead exposure on neural substrate of language development: An fMRI study." Soc. for Pediatric Radiology, New Orleans, LA, 2005.

*Yuan, W.H., Holland, S.K., Szaflarski, J.P., Schmithorst, V.J., Byars, A.W. and Strawsburg, R.H., "fMRI Shows Atypical Language Lateralization in Children with Epilepsy." ISMRM 13th Scientific Meeting, Miami, FL, 1440, 2005.

*Yuan, W.H., Szaflarski, J.P., Schmithorst, V.J., Byars, A.M., Schapiro, M.B., Strawsburg, R.H. and Holland, S.K., "fMRI Shows Differences in Hemispheric Language Dominance Between Pediatric Epilepsy Patients and Healthy Children." 3rd. Cincinnati Translational Neuroscience Symposium, Cincinnati, 2005.

Adler, C.M., Adams, J., DelBello, M.P., Holland, S.K., Schmithorst, V.J. and Strakowski, S.M., "Evidence of White Matter Pathology in First-Episode Manic Adolescents with Bipolar Disorder: A Diffusion Tensor Imaging Study." ISMRM 13th Scientific Meeting, Miami, FL, 1382, 2005.

Adler, C.M., DelBello, M.P., Holland, S.K., Schmithorst, V.J. and Strakowski, S.M., "Functional MRI Investigation of ADHD Comorbidity in Adolescent Bipolar Patients." ISMRM 13th Scientific Meeting, Miami, FL, 1450, 2005.

Cecil, K.M., Yuan, W.H., Holland, S.K., Wessel, S., Dietrich, K.M., Ris, D. and Lanphear, B., "The Influence of Childhood Lead Exposure on Language Function in Young Adults: An fMRI Study." ISMRM 13th Scientific Meeting, Miami, FL, 1441, 2005.

Chiu, P., Cummings, M.C., Schmithorst, V., Holland, S., & and Keith, R., "Sound blending in the brain: a developmental fMRI investigation." Society for Research in Child Development, Atlanta, GA, 2005.

Eliassen, J.C., Szaflarski, J.P., Holland, S.K., Schmithorst, V.J., Shear, P.K., Strakowski, S.M. and Privitera, M.J., "Compensatory activation changes outside the medial temporal lobe during a verbal recognition memory task in patients with medial temporal lobe epilepsy." American Academy of Neurology Annual Meeting, San Diego, CA, 57:2005.

Holland, S.K., Choo, D.I., Ret, J.K., Yuan, W.H., Hilbert, L. and Schmithorst, V.J., "HUSH-fMRI of Severe to Profoundly Hearing Impaired Infants and Toddlers Under Sedation." 3rd. Cincinnati Translational Neuroscience Symposium, Cincinnati, 2005.

Jacola, L., Schapiro, M.B., Patterson, B., Hickey, F., Chalfonte-Evans, M., Schmithorst, V.J., Byars, A.M., Hotze, B.S. and Holland, S.K., "Language Processing Studies with FMRI in Persons with Down Syndrome." 3rd. Cincinnati Translational Neuroscience Symposium, Cincinnati, 2005.

Jacola, L., Schapiro, M.B., Schmithorst, V.J., Byars, A.M., Wakefield, J., Strawsburg, R.H., Szaflarski, J.P. and Holland, S.K., "FMRI Reveals Atypical Language Organization in Children Following Perinatal Left MCA Stroke." 3rd. Cincinnati Translational Neuroscience Symposium, Cincinnati, 2005.

Patel, A., Arjmand, E., Karunanayaka, P., Choo, D.I., Schmithorst, V.J. and Holland, S.K., "fMRI and Outcome of Cochlear Implant in Infants." Soc. for Ear, Nose and Throat Advances in Children, Baltimore, MD, 2005.

Plante, E., Holland, S.K. and Schmithorst, V.J., "Prosodic Processing by Children: an fMRI Study." Symposium on Research in Child Language Disorders, Madison, WI, 2005:2005.

Plante, E., Schmithorst, V.J., Holland, S.K. and Byars, A.W., "Sex Differences in the Activation of Language Cortex During Childhood." Symposium on Research in Child Language Disorder, Madison, WI, 2005.

Schmithorst, V.J. and Holland, S.K., "A method for generating voxelwise between-groups statistical inferences from fMRI data using Independent Component Analysis." ISMRM 13th Scientific Meeting, Miami, FL, 1586, 2005.

Schmithorst, V.J., Holland, S.K. and Dardzinski, B.J., "Sex differences in white matter microstructure in the developing brain." ISMRM 13th Scientific Meeting, Miami, FL, 2005.

Schmithorst, V.J., Holland, S.K. and Szaflarski, J.P., "A longitudinal fMRI investigation of the development of sentential and lexical aspects of language processing in normal children." ISMRM 13th Scientific Meeting, Miami, FL, 771, 2005.

Szaflarski, J.P., Holland, S.K., Sands, S.F., Schmithorst, V.J., Lee, J.H., Strakowski, S.M., Privitera, M.J. and Eliassen, J.C., "Searching for the source of alpha rhythm: EEG-triggered fMRI at 4T." ISMRM 13th Scientific Meeting, Miami, FL, 1251, 2005.

Szaflarski, J.P., Holland, S.K., Schmithorst, V.J., Privitera, M.D., Ficker, D., Cahill, Cavitt, Meckler and Morris, "Comprehensive fMRI language evaluation in epilepsy patients." American Epilepsy Society, Washington, DC, 59th:2005.

Tillema, J.M., Jacola, L., Schapiro, M.B., Byars, A.W., Schmithorst, V.J. and Holland, S.K., "Functional MRI shows right hemispheric dominance in language processing following perinatal left MCA stroke." 57th American Academy of Neurology Annual Meeting, Miami Beach, 2005.

Chiu, C.-Y.P., Brown, R.D., Holland, S.K. and Schmithorst, V.J., "Neurodevelopment of Episodic Memory Encoding." 32nd International Neuropsychological Society, Baltimore, 2004.

Chiu, C.-Y.P., Holland, S.K., Schmithorst, V.J. and Choo, D.I., "Event-Related fMRI study of Recognition of Simulated CI Speech." VIII International Cochlear Implant Conference, Indianapolis, IN, 2004.

Holland, S.K., Choo, D.I., Ret, J.K., L., H., Dunn, R.S., O'Brien, K.J. and Schmithorst, V.J., "HUSH-fMRI of Hearing Impaired Infants and Toddlers Under Sedation." VIII International Cochlear Implant Conference, 2004.

Holland, S.K., Choo, D.I., Schmithorst, V.J., Ret, J.K., Hilbert, L., Dunn, R.S. and O'Brien, K.J., "fMRI in Hearing Impaired Children Under Sedation." ISMRM 12th Scientific Meeting, Kyoto, Japan, 4769:2004.

Szaflarski, J.P., Holland, S.K. and Schmithorst, V.J., "An fMRI Study of Cerebral Language Lateralization in 121 Children and Adults." American Academy of Neurology Annual Meeting,, San Francisco, CA, 56:2004.

Thompson, E.A., Holland, S.K. and Schmithorst, V.J., "Detecting Cortical Activations from fMRI Data Using a Recursive STAP algorithm." International Symp. of Biomedical Imaging, Arlington, VA, 2004.