Reproductive Sciences

SK Dey, PhD

Title

Lova Riekert Chair and Professor of Pediatrics, Cancer and Cell Biology

Director, Division of Reproductive Sciences

Appointment

Professor, University of Cincinnati College of Medicine

Email

sk.dey@cincinnatichildrens.org

Phone

513-803-1158

Fax

513-803-1160

Bio

Dr. Dey received his PhD from Calcutta University in 1972, after which he obtained postdoctoral training at Kansas University Medical Center from 1973-1977, followed by his faculty appointment in 1977 where he rose to the rank of University Distinguished Professor. He moved to Vanderbilt University as Dorothy Overall Wells Professor of Pediatrics, Cell & Dev Biology and Pharmacology in 2002. In both places, he directed NIH-funded reproductive biology training grants. In 2008, Dr. Dey moved to Cincinnati Children’s Hospital Medical Center as Lova Riekert Chair and Professor of Pediatrics to start a new Division of Reproductive Sciences. He has published over 250 original articles and is funded by two MERIT Awards and a Program Project Grant from NIH. His research mission has been to define the molecular road map to embryo-uterine interactions during pregnancy. His recent work published in Nat Med and JCI provides novel information in the context of ectopic pregnancy and progesterone resistance to pregnancy failure. In 2008, Dr. Dey received Carl G. Hartman Award, the highest honor of the Society for the Study of Reproduction.

He has graduated 5 PhD students, and mentored 35 postdoctoral students, 20 of whom are currently independent faculty members, and most others are investigators in major research institutions. His laboratory currently consists of 4 postdoctoral fellows, 1 graduate student, 1 MD/PhD student, 1 visiting graduate student and two research assistants.

Credentials

BSc: University of Calcutta, India, 1965
MSc: University of Calcutta, India, 1967
PhD: University of Calcutta, India, 1972

Awards and Honors

IVI, Schering Plough Award, 2009

Carl G. Hartman Award, Society for the Study of Reproduction, 2008

Co-chair, SSR Endowment Committee, 2007-present

Recipient of a MERIT Award, NIDA/NIH, 2003-

Dorothy Overall Professor, Vanderbilt University Medical Center, 2002-2008

Recipient of the Research Investigator Award, Society for the Study of Reproduction, 2001

Recipient of a MERIT Award, NICHD/NIH, 1999-

University Distinguished Professor, University of Kansas, 1999

Recipient of Higuichi Achievement Award, University of Kansas, 1999

Recipient of University of Kansas Chancellor’s Club Research Award, 1995

Recipient of Senior Investigator Award, University of Kansas Medical Center, 1988

Research

Prostaglandin-nuclear receptor-angiogenic signaling axis during embryo implantation with special emphasis to cPLA2α-Cox2-PPARδ-Vegf network in the uterus.
Cytokine-growth factor-homeobox-morphogen signaling axis in implantation involving Lif-Hb-Egf-Hoxa10/Msx1-Ihh/Bmp/Wnt network in the uterus.
Immunophilin/cochaperone-nuclear signaling in the mouse uterus during implantation involving Fkbp52-PR.
Ligand-receptor signaling with endocannabinoids during the periimplantation events in mice in the context of anandamide interacting with G-protein coupled receptors, CB1 and CB2.
Molecular and genetic basis of epithelial ovarian cancer with special reference to prostaglandin-PPAR signaling.
miRNA and Cox-2 regulation in uterine biology and cancer
Pten and uterine carcinoma: conditionally gene deleted mouse models

Publications, Most Recent

Burnum, K. E., Cornett, D. S., Puolitaival, S. M., Milne, S. B., Myers, D. S., Tranguch, S., Brown, H. A., Dey, S. K., and R. M. Caprioli. (2009). Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation.J Lipid Res. In press.

Daling, J. R., Doody, D. R., Sun, X., Trabert, B. L., Weiss, N. S., Chen, C., Biggs, M. L., Starr, J. R., Dey, S. K., and S. M. Schwartz. (2009). Association of marijuana use and the incidence of testicular germ cell tumors. Cancer 115(6): 1215-23.

Huang, X., Ketova, T., Fleming, J. T., Wang, H., Dey, S. K., Litingtung, Y., and C. Chiang. (2009). Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.Development.

Lim, H. J. and S. K. Dey (2009). HB-EGF: a unique mediator of embryo-uterine interactions during implantation. Exp Cell Res 315(4): 619-26.

Sun, X., Wang, H., Okabe, M., Mackie, K., Kingsley, P. J., Marnett, L. J., Cravatt, B. F. and S. K. Dey. (2009). Genetic loss of Faah compromises male fertility in mice. Biol Reprod 80(2): 235-42.

Wang, H., Xie, H., and S. K. Dey. (2008). Loss of cannabinoid receptor CB1 induces preterm birth.PLoS One 3(10): e3320.

Von Stetina JR, Tranguch S, Dey SK, Lee LA, Cha B, Drummond-Barbosa D. (2008). alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila. Development 135(22): 3697-706.

Sun X., Dey, SK. (2008). Aspects of endocannabinoid signaling in periimplantation biology.Mol Cell Endocrinol 286(1-2 Suppl 1): S3-11.

Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey, SK, DuBoid, RN. (2008). Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.Cancer Res 68(22): 9331-7.

Horne AW, Phillips JA, 3rd, Kane N, Lourenco, PC, McDonald SE, Williams AR, Simon C, Dey SK, Critchley, HO. 3rd, et al. (2008). CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PLoS One 3(12): e3969.

Daikoku T, Dey SK (2008). Two faces of PTEN. Nat Med 14(11): 1192-3.

Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK. Deficiency of immunophilin FKBP52 promotes endometriosis. American Journal of Pathology 2008;173(6): 1747-57.

Wang D, Wang H, Wei N, Backlund M, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Research 2008;68(15): 6468-76.

Daikoku T, Hirota Y, Tranguch T, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Research 2008;68:5619-27.

Burnum KE, Tranguch S, Mi D, Daikoku T, Dey SK, Caprioli RM. Imaging mass spectrometry reveals unique protein profiles during embryo implantation. Endocrinology 2008;149:3274-8.

Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, Wang H. Inactivation of nuclear Wnt-β-Catenin signaling limits blastocyst competency for implantation. Development 2008;135:717-27.

Xie H, Wang H, Tranguch S, Iwamoto R, Mekada E, DeMayo F, Lydon J, Das SK, Dey SK. Maternal heparin-binding EGF deficiency limits pregnancy success in mice. Proc Natl Acad Sci USA 2007;104:18315-20.

Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK. Stage-specific integration of maternal and embryonic PPAR signaling is critical to pregnancy success. Journal Biol Chem 2007;282:37770-82.

Chakrabarty A, Tranguch S, Daikoku T, Jensen K, Furneaux H, Dey SK. MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci USA 2007;104:15144-9.

Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPAR activation. J Exp Med 2007;204:2053-61.

Tranguch S, Chakrabarty A, Guo Y, Wang H, Dey SK. Maternal pentraxin-3 deficiency compromises implantation in mice. Biology of Reproduction 2007;77:425-32.

Sadikot RT, Zeng H, Azim AC, Joo M, Dey SK, Breyer RM, Peebles RS, Blackwell TS, Christman JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur J Immunology 2007;34:1001-9.

Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, DuBois RN, Dey SK. Extracellular signal-regulated kinase is a target of COX-1-PPARδ signaling in epithelial ovarian cancer. Cancer Research 2007;67:5285-92.

Tranguch S, Wang H, Daikoku T, Xie H, Smith D, Dey SK. FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific. J Clin Investigation 2007;117:1824-34.

Hong J, Kim ST, Tranguch S, Smith DF, Dey SK. Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Reproduction 2007;133: 395-403.

Wang H, Xie H, Sun X, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins and Other Lipid Mediators 2007;83:62-74.

Presentations, Most Recent

Invited Speaker

Invited Speaker, March 16-18, 2009 Society of Gynecologic Investigation, Glasgow, Scotland, UK
Invited Speaker, October, 20-21, 2008, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9038.
Invited Speaker, September 26-28, 2008, EMD Serono, Boston, MA.
Invited Speaker, September 11-14, 2008, North American Vascular Biology Organization, Cape Cod, MA.
24th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE), July 6-9, 2008, Barcelona, Spain.
May 6, 2008, Molecular Toxicology, NIEHS, Research Triangle Park, NC.
11th Frontiers in Nuclear Receptor Action Conference to be held April 10-12, 2008 (Sponsored by Wyeth).
SGI International Summit Meeting on Reproductive Medicine, November 8-10, 2007, Valencia, Spain.
September 5, 2007, Konkuk University, Seoul, Korea.
September 3, 2007, State Key laboratory, Beijing, China.
September 3, 2007, China Agricultural University, Beijing, China.
September 2, 2007, Beijing Agricultural University, Beijing, China.
Basic and Pharmacological Aspects of Cannabinoid Activity in Nervous and Reproductive Systems, June 14-15, 2007, Naples, Italy.
Texas A&M University, March 23, 2007.
Placenta Satellite Meeting, Society of Gynecologic Investigation, March 14, 2007, Reno, Nevada.
Winter Eicosanoid Meeting, March 11-12, 2007, Baltimore, MD.
Duke University, December 13-14, 2006, Durham, NC.
Endocrine Society Annual Meeting, June 24, 2006, Boston, MA.
April 3-5, 2006, Cornell University Medical Center, Ithaca, New York.
12th World Congress on Gynecological Endocrinology, Florence, Italy, 2-5 March 2006.
October 11-12, 2005, Fox Chase Cancer Center, PA.
September 15, 2005, NIEHS, Research Triangle Park, NC.
7th Winter Eicosanoid Symposium, March 21-23, 2005, Baltimore, MD.
Research Seminar, June 30-July1, 2004, Sanofi-Synthelabo, Melvin, PA.
Research Seminar, April 27-28, 2004, University of Pennsylvania, PA.
Research Seminar, April 21-22, 2004, Mayo Clinic, Scottsdale, AR.
Lipidomics Satellite Meeting, NIDA/NIH, April 14-16, 2004, Washington, DC.

Special Lectures and Meetings

Keynote Speaker, IVI International Award Presentation, May 14-16, 2009, Madrid, Spain.
Keynote Speaker, Annual Meeting of Japanese Society of Fertilization and Implantation, August 28-30, 2007, Sendai, Japan
Invited Speaker, Society for Reproduction & Fertility, July 4-5, 2006, Leeds, UK.
Keynote Speaker, Annual Meeting, American Society of Reproductive Immunology, June 15-17, 2006, Nashville, TN.
Invited Speaker, Serono Symposia on Human Implantation, May 5-6, 2006, Erice (Sicily), Italy.
D. C. Johnson Memorial Lecture, March 20, 2006, Kansas University Medical Center, Kansas City, KS.
Endowed Lecture, September 27-28, 2005, Dartmouth Medical School, NH.
Invited speaker, Understanding of Preterm Birth, Institute of Medicine, NAS, August 10, 2005, Washington, DC.
Invited Speaker, Lipidomics Workshop, NIDA/NIH, June 12-17, 2004, San Juan, Puerto Rico.
Invited Speaker, Novartis Foundation, Biology of the Trophoblast discussion meeting, March 16-19, 2004, London, UK.
Invited Participant-Advisor, Workshop, SCHERING, New Approaches to Female Contraception, September 6-10, 2003, Berlin Germany.