Integrative Genomics and Pediatric Arthritis
The Juvenile Rheumatoid Arthritis (JRA) Affected Sib-Pairs Registry has now collected DNA on over 200 sib-pairs and is now moving to international recruiting. The first publication on genome wide screen in JRA utilized this cohort.
Complementing this wide-scale genotyping project is a gene expression project following 300 new onset JRA and spondyloarthropathy patients with gene expression of serial peripheral blood samples. This is funded through a program project grant (Primary Investigator, David N. Glass, MD). A recently awarded RO1 entitled Genomic Landscapes in Large Scale Integrated JRA Studies (Primary Investigator, Susan D. Thompson, PhD) with two mathematicians, Michael Wagner, PhD, and Dr. Jarek Miller from the Division of Biomedical Informatics at Cincinnati Children's Hospital Medical Center, as co-investigators will allow development of models integrating genomic and gene expression data and testing the models in JRA data sets.
Publications
Thompson SD, Moroldo MB, Guyer L, Ryan M, Tombragel EM, Shear ES, Furlow S, Sudman M, Keddache MA, Brown WM, Giannini EH, Langefeld CD, Rich SS, Nichols WC, Glass DN: A genome-wide screen in juvenile rheumatoid arthritis (JRA) affected sib pair families. Arthritis Rheum 50: 2920-30, 2004
Moroldo MB, Chaudhari M, Shear ES, Thompson SD, Glass DN, Giannini EH: Juvenile rheumatoid arthritis (JRA) affected sib pairs: Extent of clinical phenotype concordance. Arthritis Rheum 50: 1928-34, 2004
Barnes MG, Aronow BJ, Luyrink LK, Moroldo MB, Pavlidis P, Passo MH, Grom AA, Hirsch R, Giannini EH, Colbert RA, Glass DN and Thompson SD. Gene expression in juvenile arthritis: A pro-angiogenic ELR+ chemokine gene cluster relates to course of arthritis. Rheumatology (Oxford) 43:973-9, 2004
