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Dr. Biro's work focuses on pubertal maturation − how timing of puberty is impacted by the physical, chemical and social environment, and how changes associated with puberty impact adolescent and adult morbidity and mortality.
Dr. Biro is currently working on several grants funded through NIEHS, NCI and NICHD. The major study has followed 379 girls, ages 6 and 7, seen every six weeks at their school or in the Clinical and Translational Research Center (CTRC). The original BCERC generated over 3000 visits. During the visits, girls receive several evaluations: blood pressure, height, weight, skin folds, waist and hip circumference, bioelectrical impedance and pubertal maturation. Blood is drawn every visit, and once a year, urine and blood are obtained for selected biomarkers. Blood is obtained for DNA and RNA (microarray analysis). Parents are called every three months for a 24-hour diet recall. Adherence to the protocol has been very high, with >90 percent retention. Blood has been obtained at over 89 percent of visits, urine over 95 percent of scheduled visits, and study questionnaires at over 97 percent of visits.
Average age at intake into the study was 7.1 years of age. At age 8, 29 percent of white, 48 percent of black and 33 percent of Hispanic girls were breast stage 2 or greater; these proportions are significantly greater than those published by Herman-Giddens et al (1997).
Learn more about the Growing Up Female study.
Learn more about the Breast Cancer and the Environment Research Program.
In-Iw S, Biro FM. Adolescent women and obesity. J Pediatr Adolesc Gynecol. 24(2):58-61. Apr, 2011.
Hernick AD, Brown MK, Pinney SM, Biro FM, Ball KM, Bornschein RL. Sharing unexpected biomarker results with study participants. Environ Health Perspect. 119(1):1-5. Jan, 2011.
Hillman JB, Biro FM. Dynamic changes of adiposity during puberty: life may not be linear.J Adolesc Health. 47(4):322-3. Oct, 2010.
Biro FM, Galvez MP, Greenspan LC, Succop PA, Vangeepuram N, Pinney SM, Teitelbaum S, Windham GC, Kushi LH, Wolff MS. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics. 126(3):e583-90. Sep, 2010.
Biro FM, Wien M. Childhood obesity and adult morbidities. Am J Clin Nutr. 91(5):1499S-1505S. May, 2010.
Windham GC, Pinney SM, Sjodin A, Lum R, Jones RS, Needham LL, Biro FM, Hiatt RA, Kushi LH. Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls. Environ Res. 110(3):251-7. Apr, 2010.
Biro FM, Huang B, Morrison JA, Horn PS, Daniels SR. Body mass index and waist-to-height changes during teen years in girls are influenced by childhood body mass index. J Adolesc Health. 46(3):245-50. Mar, 2010.
Huang B, Biro FM, Dorn LD. Determination of relative timing of pubertal maturation through ordinal logistic modeling: evaluation of growth and timing parameters. J Adolesc Health. 45(4):383-8. Oct, 2009.
Ford KR, Khoury JC, Biro FM. Early markers of pubertal onset: height and foot size. J Adolesc Health. 44(5):500-1. May, 2009.
Auslander BA, Biro FM, Succop PA, Short MB, Rosenthal SL. Racial / ethnic differences in patterns of sexual behavior and STI risk among sexually experienced adolescent girls. J Pediatr Adolesc Gynecol. 22(1):33-9. Feb, 2009.
Biro FM, Wolff MS, Kushi LH. Impact of yesterday's genes and today's diet and chemicals on tomorrow's women. J Pediatr Adolesc Gynecol. 22(1):3-6. Feb, 2009.
Biro FM, Huang B, Daniels SR, Lucky AW. Pubarche as well as thelarche may be a marker for the onset of puberty. J Pediatr Adolesc Gynecol. 21(6):323-8. Dec, 2008.
Biro FM, Emans SJ. Whither PCOS? The challenges of establishing hyperandrogenism in adolescent girls. J Adolesc Health. 43(2):103-5. Aug, 2008.
Frank M. Biro, MD
Phone: 513-636-8602Fax: 513-636-1129Email: email@example.com
Read more about this study.
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