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The Division of Allergy and Immunology at Cincinnati Children’s strives to provide the best treatment of allergic and immunologic disorders and conducts leading research focused on elucidating the causes, mechanisms and most effective treatment of allergic and immunological diseases.
Our research spans fundamental studies, translational investigation, and clinical trials. Novel models of immunological diseases, developed and / or fine-tuned by divisional researchers, provide unprecedented systems to investigate key inflammatory steps involved in pediatric allergic and immunological disease and to enhance our understanding of mast cells, eosinophils, macrophages and lymphocytes.
Our integrative laboratories, such as the Rothenberg, Hogan, and Zimmermann Labs, are led by nationally recognized researchers and employ state-of-the-art model systems for genetic, biochemical, immunological and physiological analysis.
Our division is dedicated to educating the next generation of leaders in allergy and immunology clinical practice and research. We have competitive clinical and research fellowship and postdoctorate programs and mentor students of several graduate programs (Molecular and Developmental Biology, Immunobiology, Molecular Genetics, Biochemistry and Microbiology).
To improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research.
We focus on uncovering the molecular mechanisms (steps) of inflammation, primarily those involved in allergic and other immune-mediated disorders.
We concentrate on discovering key processes in the initiation and propagation of allergic and other immune-mediated responses in the lung (asthma), skin (eczema), upper respiratory tract (allergic rhinitis) and gastrointestinal tract (especially eosinophilic gastrointestinal disorders, inflammatory bowel disease and food allergy) as well as systemically (anaphylaxis). Molecular pathways involved in macrophage activation syndrome (perforin mutations) and hypereosinophilic syndrome (IL-5 and activated tyrosine kinases) are primary focus areas.
We focus on uncovering clinical, genetic and therapeutic principles concerning asthma, eosinophilic disorders (e.g., eosinophilic esophagitis and hypereosinophilic syndrome), macrophage activation syndrome and food allergy. Innovative clinical trials, based on fundamental and translational laboratory findings, are highly prioritized.
Learn more about our clinic. We offer comprehensive care for children with allergic and immunologic disorders as well as opportunities for clinical research studies.
Our investigators conduct studies in collaboration with outstanding researchers locally, nationally and internationally.
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