Fundamental Studies
We focus on uncovering the molecular mechanisms (steps) of inflammation, primarily those involved in allergic and other immune-mediated disorders.
Translational Investigation
We concentrate on discovering key processes in the initiation and propagation of allergic and other immune-mediated responses in the lung (asthma), skin (eczema), upper respiratory tract (allergic rhinitis) and gastrointestinal tract (especially eosinophilic gastrointestinal disorders) as well as systemically (anaphylaxis). Molecular pathways involved in macrophage activation syndrome (perforin mutations) and hypereosinophilic syndrome (IL-5 and activated tyrosine kinases) are primary focus areas.
Clinical Trials
We focus on uncovering clinical, genetic and therapeutic principles concerning asthma, eosinophilic disorders (e.g., eosinophilic esophagitis and hypereosinophilic syndrome) and macrophage activation syndrome. Innovative clinical trials, based on fundamental and translational laboratory findings, are highly prioritized.
