• New Cell Type May Help Explain Why Some People Have Dangerous Food Allergies

    Yui-Hsi Wang, PhD and his colleagues report their discovery of a new cell type that appears to drive life-threatening food allergies and may help explain why some people get severe allergic reactions and others do not.

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  • Type 1 Kabuki Syndrome Evidences B-cell Terminal Differentiation Defects

    Kabuki syndrome is a multisystem developmental disorder.  Andrew W. Lindsley, MD, PhD recently characterized the humoral immune defects found in patients with Kabuki syndrome with mutations in a protein that modifies histones, lysine methyltransferase 2D (KMT2D). Autosomal dominant KMT2D mutations were associated with dysregulation of terminal B-cell differentiation, leading to humoral immune deficiency and, in some cases, autoimmunity. These data suggest that patients with KS should undergo serial clinical immune evaluations.Read more