• Caspase Activation

    Cytotoxic T lymphocytes are critical for eliminating virus-infected cells and malignant cells in the body and target cells by perforin-mediated or Fas-mediated methods. Kimberly A. Risma, MD, PhD and colleagues used a novel, real-time assay to demonstrate the distinct pattern of caspase activation induced by granzyme B versus Fas in human and murine cytotoxic T lymphocytes.Read More
  • Tissue Specificity of Eosinophilic Esophagitis

    Tissue Specificity of Eosinophilic Esophagitis
    Leah C. Kottyan, PhD and Marc E. Rothenberg, MD, PhD and colleagues recently conducted a genome-wide association analysis of eosinophilic esophagitis (EoE), a chronic inflammatory disorder associated with allergic hypersensistivity to food. Their findings, published in Nature Genetics, suggest that the tissue-specific nature of EoE involves the interplay of allergic sensitization with an EoE-specific, interleukin-13-inducible esophageal response involving CAPN14.Read more