Allergy and Immunology

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Allergy and Immunology

Research Highlights
2013 Primary Research Publications

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April

Intestinal CCL11 and Eosinophilic Inflammation is Regulated by Myeloid Cell-Specific RelA/p65 in Mice.

March

Eosinophil Adoptive Transfer System to Directly Evaluate Pulmonary Eosinophil Trafficking In Vivo.
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of ImmuneActivation in Hemophagocytic Lymphohistiocytosis.
Targeted Ablation of miR-21 Decreases Murine Eosinophil Progenitor Cell Growth.
PedsQL™ Eosinophilic Esophagitis Module: Feasibility, Reliability and Validity.

January

Chymase Mediated Intestinal Epithelial Permeability is Regulated by Protease Activating Receptor (PAR)-2/ Matrix Metalloproteinase (MMP)-2-dependent Mechanism.
miR-223 Deficiency Increases Eosinophil Progenitor Proliferation.
The E3 Ubiquitin Ligase Midline 1 Promotes Allergen and Rhinovirus-induced Asthma by Inhibiting Protein Phosphatase 2A Activity.
Research Highlights Prior to 2013

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2012

RNF8 Regulates Active Epigenetic Modifications and Escape Gene Activation from Inactive Sex Chromosomes in Post-meiotic Spermatids.
Long-term Safety of Mepolizumab for the Treatment of Hypereosinophilic Syndromes.
The Role of TRB3 in Mast Cells Sensitized with Monomeric IgE.
Development of the Pediatric Quality of Life InventoryTM Eosinophilic Esophagitis Module items: Qualitative Methods.
Behavioral Feeding Problems and Parenting Stress in Eosinophilic Gastrointestinal Disorders in Children.
In Vivo Regulation of TGF-β by R-Ras2 Revealed through Loss of the RasGAP Protein NF1.
Trefoil Factor 2 Negatively Regulates Type 1 Immunity Against Toxoplasma Gondii.
The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research.
The Murine CCR3 Receptor Regulates Both Eosinophilia and Hyperresponsiveness in IgE-mediated Allergic Conjunctivitis.
Toll-like Receptor 7 is Required for Effective Adaptive Immune Responses that Prevent Persistent Virus Infection.
Evidence That Formation of Vimenin:Mitogen-activated Protein Kinase (MAPK) Complex Mediates Mast Cell Activation following Fc{epsilon}RI/CC Chemokine Recepotr 1 Cross-talk.
Comparative Dietary Therapy Effectiveness in Remission of Pediatric Eosinophilic Esophagitis.
Induction and Suppression of Allergic Diarrhea and Systemic Anaphylaxis in a Murine Model of Food Allergy
Pharmacokinetics, Tissue Distribution and Immunomodulatory Effect of Intralipid Formulation of Nystatin in Mice.
Mouse Sensitization as an Independent Risk Factor for Asthma Morbidity.
MicroRNA Signature in Patients with Eosinophilic Esophagitis, Reversibility with Glucocorticoids, and Assessment as Disease Biomarkers.
Behavioral Functioning and Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders.
MiR-375 is Downregulated in Epithelial Cells After IL-13 Stimulation and Regulates an IL-13-induced Epithelial Transcriptome.
Identification of Anti-Retinal Antibodies in Patients with Age-Related Macular Degeneration.
Intestinal Mast Cell Levels Control Severity of Oral Antigen-Induced Anaphylaxis in Mice.
Esophageal Functional Impairments in Experimental Eosinophilic Esophagitis.
Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.

2011

Reslizumab in Children and Adolescents with Eosinophilic Esophagitis: Results of a Double-Blind, Randomized, Placebo-Controlled Trial.
The Pan-B Cell Marker CD22 Is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia.
Development of a Validated Patient-Reported Symptom Metric for Pediatric Eosinophilic Esophagitis: Qualitative Methods.
Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders.
Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization.
IL-13 Receptor {alpha}1 Differentially Regulates Aeroallergen-Induced Lung Responses.
MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-{gamma} Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity.
An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children with Eosinophilic Esophagitis.
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial hemophagocytic lymphohistiocytosis.
Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor.
An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis.
Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition
Quality of life in paediatric eosinophilic oesophagitis: what is important to patients?
Long-term outcomes in pediatric-onset eosinophilia.
Perforin is a critical physiologic regulator of T-cell activation.
Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.
Agonist activation of F-Actin-mediated eosinophil shape change and mediator release is dependent on Rac2.
Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses.
Murine guanylate cyclase C regulates colonic injury and inflammation.
Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.
Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.
TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.
Advances in mechanisms of asthma, allergy, and immunology in 2010.
Differences in candidate gene association between European ancestry and African American asthmatic children.  
Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation.  
Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.
Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.
Comparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis.
Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.
T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.
A striking local esophageal cytokine expression profile in eosinophilic esophagitis.
Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report.
T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.
A striking local esophageal cytokine expression profile in eosinophilic esophagitis.
Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report.

2010

Regulation of Lung Fibrosis in Inflammatory Lung Models by Cationic Amino Acid Transporter 2.
IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.
Involvement of mast cells in eosinophilic esophagitis.
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.
Induction of Experimental Eosinophilic Esophagitis by Indoor Insect Allergens (PDF).
Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.
Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenic in mice.
Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51.
Common variants at 5q22 associate with pediatric eosinophilic esophagitis - News Release
Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.
Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.
Health-related quality of life across pediatric chronic conditions.
Different roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis.
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.
Evidence of IgE Response in Patients with Eosinophilic Esophagitis.

2009

A Pathway for Connecting Intestinal Inflammation with Metabolic Problems is Identified

2008

An Allergy Associated Mediator is Shown to Induce Intestinal Inflammation
The Mechanism of Mast Cell Growth and Involvement in Hypereosinophilic Syndrome is Defined
A New Approach to Blocking Eosinophils in Vivo is Shown in a Pre-Clinical Study
A New Pathway Involved in Eosinophilic Esophagitis is Identified
A Novel Regulatory Molecule PIR-B in Eosinophil Activation and Inhibition is Reported
The Familial Form of Eosinophilic Esophagitis is Described and the Clinical and Genetic Aspects Defined
The Action of Anti-IL-5 in Eosinophilic Patients is Defined
The Receptor Involved in Eliciting Allergic Lung Responses to IL-4 and IL-13 is Elucidated
Anti-IL-5 Therapy in Patients with Hypereosinophilia is Shown to be Successful
The Mechanism of Esophageal Scarring in Eosinophilic Esophagitis is Identified

2007

IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.
A Long-term Follow-up of Pediatric Patients with Eosinophilic Esophagitis is Reported

2006

Early Biomarkers for Eosinophilic Esophagitis are Identified
The Key Importance of Eotaxin Receptor CCR3 is Reported
The First Placebo-controlled Trial for Eosinophilic Esophagitis Reports Benefit of Swallowed Fluticasone
An In Vivo Model of Hypereosinophilic Syndrome Involving FIP1L1-PDGFR is Reported
Gene Discovery Linked to Mysterious Chronic Food Allergy: First Molecular Insight into Eosinophilic Esophagitis - News Release

2004

Two Studies in Science Point to New Evidence in Asthma Development: Eosinophils Have a Key Role in Asthma
Study in The New England Journal of Medicine Identifies Rapidly Rising Disorder
Study Identifies Breakthrough Treatment for Devastating Blood Disorders

2001

Study Identifies Culprits in Food Allergy Inflammation

2000

Cincinnati Children’s Researcher Uncovers Allergy / Reflux Link: Study Has Significant Treatment Implications
Cincinnati Children’s Researchers Uncover Critical Food Allergy Pathway

CD22 Expression on Gastrointestinal Eosinophils

Reproduction of part of Figure 3, panel B published in The Journal of Immunology (February 1, 2012, vol. 188, p. 1075-1082), showing cell membrane expression of Pan-B cell marker CD22 on gastrointestinal eosinophils of wildtype mice by FACS and flow imaging analysis. Copyright 2011. The American Association of Immunologists, Inc. Read the abstract.
Intestinal Mast Cells in Anaphylactic Severity

A recent mouse study from the Hogan Lab indicates that the density of intestinal mast cells controls the severity of oral antigen-induced anaphylaxis. These findings were published in The American Journal of Pathology. Read the abstract.

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