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Eosinophils are continuously being generated in the bone marrow from a small pool of hematopoietic stem cells (HSCs). During differentiation into an eosinophil, HSCs go through distinct stages, including a myeloid progenitor followed by commitment to the eosinophil lineage with generation of the eosinophil-lineage committed progenitor (EoP), prior to reaching maturity. The factors that direct the developmental program of myeloid progenitor to EoP to mature eosinophil remain under-investigated, likely due to the rarity of these cells in healthy human bone marrow. We have developed a culture method to generate myeloid progenitors and EoPs from human HSCs to characterize the stages of human eosinophil development and identify the regulators of eosinophilopoiesis.
Michael is an undergraduate working in the Fulkerson Lab while attending Thomas More College. He is working to optimize specific assays, such as the eosinophil peroxidase assay (EPO), for the Eosinophil Progenitor Differentiation research.
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