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The Fulkerson Lab provides training for postdoctoral fellows, graduate students, pediatric fellows, medical students and undergraduate students. We are committed to a team approach to our science and research program and highly value input from all members of the lab. In addition to one-on-one meetings, the members of the Fulkerson Lab meet once a week to review data, discuss ideas and review progress. We also have bimonthly Lunch and Learn sessions in which we gather together to learn about a new technique or delve deeper into a new area of research from invited speakers. Sharing our work with the scientific community is an important aspect of the training experience as it allows us to develop presentation skills and to gain feedback and insight from other knowledgeable investigators.
Carine (above far left) is a postdoctoral research fellow. She joined the Fulkerson Lab in May 2013. In France, she earned her PhD researching mesenchymal stem cells and their ability to reduce inflammation in arthritis. Her current research projects are focused on gene regulation in eosinophil progenitors using both murine bone marrow and human stem cell culture systems. She loves to cook and play basketball.
David (above far right) is a postdoctoral clinical fellow in the Division of Allergy and Immunology. He joined the Fulkerson Lab in July 2013. His research project is focused on characterizing eosinophil progenitors mobilized from the bone marrow in patients with allergy and eosinophilic diseases.
We have weekly lab meetings to discuss results and plan out experiments. We work hard and keep everything organized. Daily communication by email and in person also helps us make the most of our time and resources.
Lab members work at the bench with protein, RNA and DNA isolated from cells to further the understanding of eosinophil development. We have a variety of assays that we have developed to study the effector functions of eosinophils, including gene expression, mediator production, degranulation and chemotaxis. We are always interested in developing new assays to advance our research program.
Abby Stein, a University of Cincinnati medical student who worked in the Fulkerson Lab in the summer of 2013 as part of the SMURRF program, won first place for her oral presentation of her research project investigating the kinetics of eosinophil and eosinophil progenitor (EoP) production and mobilization in an asthma model. She did a wonderful job both in the presentation and throughout the summer as she tackled a technically challenging project. As a result of her win, Abby will be representing Cincinnati Children's (and the Fulkerson Lab) at The National Student Research Forum at the University of Texas.
Abby Stein, a University of Cincinnati medical student who worked in the Fulkerson Lab in the summer of 2013 as part of the SMURRF program, won best poster presentation in the Immunology category at the 55th Annual National Student Research Forum (NSRF) at the University of Texas. Her summer research project focused on eosinophil progenitors in experimental asthma, and she represented Cincinnati Children's, the University of Cincinnati, and eosinophil progenitors very well!
We use bone marrow cells from wild-type and genetically modified mice as a model for mammalian hematopoiesis. Our mice are housed within a barrier facility in an AAALAC-accredited vivarium with veterinary care provided by Veterinary Services.
Michael Stephens, a talented undergraduate student working in the Fulkerson Lab, earned an Honorable Mention at the 2013 SURF Poster Symposium for his studies showing a role for Spi-C in eosinophil peroxidase (EPO) expression in murine eosinophils! This is a considerable accomplishment with the absolute number of posters and great work done by the students across both campuses every summer. Michael was back in the lab doing EPO assays right after the poster session - a dedicated scientist already.
Michael Stephens, an undergraduate researcher in the Fulkerson Lab, presented at the annual, regional meeting of the Northeast-4 district (the states of KY, OH, and MI) of the National Biological Honors Society and won the Frank G. Brooks award, which is awarded to the first place recipient for podium presentations. He was awarded with a plaque and certificate and provided funds for him to present at the national conference this year. Michael is pictured here with Dr. Eugene Burns, who is the chair of the district.
The Fulkerson Lab utilizes ex vivo tissue culture systems with primary cells to study eosinophil and myeloid cell development. Lab members spend time in the tissue culture hood isolating cells from bone marrow harvested from the femurs of mice as well as maintaining and manipulating cultures with human stem cells, umbilical cord blood progenitors and other cells.
Patricia C. Fulkerson, MD, PhD was awarded a 2013 ARTrustTM Faculty Development Award by the American Academy of Allergy, Asthma and Immunology. This funding supports our research investigating the regulation of eosinophil progenitors by Toll-like receptors.
David Morris, a clinical fellow in the Fulkerson Lab, was awarded a 2014 ARTrust Award by the American Academy of Allergy, Asthma and Immunology for his grant entitled "Characterization of eosinophil progenitors in the peripheral blood of pediatric patients with active eosinophilic esophagitis."
Our research program requires extensive flow cytometry analysis and cell sorting. Eosinophil progenitors (EoPs) are a rare cell population, which we identify by expression of specific cell surface markers. We look for changes in the number of EoPs in treated and genetically modified cultures and mice, as well as purify EoPs via cell sorting for ex vivo studies.
Michael Stephens, an undergraduate working in the Fulkerson Lab, won first place in a research competition in Physiology and Biochemistry at the 2012 Annual Meeting of the Kentucky Academy of Science (KAS) hosted at Eastern Kentucky University for his work on optimizing the eosinophil peroxidase (EPO) assay. Go Michael! Thumbs up for success!
Our division has a weekly Allergy/Immunology Data Club with speakers from throughout the division, including us!
Our lab has a bi-monthly Lunch and Learn in which we bring in speakers from the hospital or University of Cincinnati to educate us on topics and techniques related to our research.
Our division offers fellowship training in pediatric and adult allergy / immunology in collaboration with the University of Cincinnati. Patty is a supporter and former fellow of this outstanding program. Here’s a picture of the 2012 fellows along with the former (lower left) and current (lower right) allergy fellowship directors.
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