• Research Faculty

    Our research spans fundamental studies, translational investigation and clinical trials. Novel models of immunological diseases, developed and/or fine-tuned by divisional researchers, provide unprecedented systems to investigate key inflammatory steps involved in pediatric allergic and immunological disease and to enhance our understanding of mast cells, eosinophils, macrophages and lymphocytes. Our integrative laboratories are led by nationally recognized researchers and employ state-of-the-art model systems for genetic, biochemical, immunological and physiological analysis.

    Read more about our faculty's research below.

  • A photo of Marc Rothenberg.

    Marc E. Rothenberg, MD, PhD Director, Division of Allergy and Immunology

    is focused on elucidating mechanisms of allergic responses, especially in mucosal tissues such as the lung and the gastrointestinal tract, in order to identify novel pharmaceutical targets for treatment of patients with eosinophilic diseases including eosinophilic gastrointestinal disorders, hypereosinophilic syndromes and asthma and food allergies. Lab has identified and characterized several critical pathways that regulate allergic responses. 

    Visit the Rothenberg Lab website.


    A photo of J. Pablo Abonia.

    J. Pablo Abonia, MD Interim Director, Registry for Eosinophilic Disorders (REGID)

    assesses the biology and regulation of mast cells and their role in disease such as eosinophilic esophagitis and primary mast cell disease. Conducting translational research and clinical trials and developing patient databanks and bioinformatic approaches to understanding allergic disease. Sees patients at the Cincinnati Center for Eosinophilic Disorders. Involved in the national Registry for Eosinophilic Gastrointestinal Disorders (REGID).


    A photo of Amal Assa'ad.

    Amal H. Assa'ad, MD Associate Director, Division of Allergy and Immunology

    centers her research on food allergy and asthma. She has established a food allergy research to study the optimal diagnosis for food allergies and reactions and potential treatments, including desensitization protocols. Dr. Assa’ad conducts clinical trials using novel biologic agents for the treatment of eosinophilic disorders, including those of the gastrointestinal tract, and for the treatment of severe asthma in pediatric and adult patients.


    A photo of Artem Barski.

    Artem Barski, PhD

    uses cutting-edge genomic technologies (such as ChIP-Seq and RNA-Seq) to understand contribution of epigenetic mechanisms and polymerase stalling to T cell activation, differentiation and to formation of T cell memory.
    Visit the Barski Lab.


    A photo of Patricia Fulkerson.

    Patricia C. Fulkerson, MD, PhD

    researches the biology of the eosinophil-lineage committed progenitor (EoP). Aiming to identify novel therapeutic targets to block eosinophil production for the treatment of patients with eosinophilic disorders, she investigates transcriptional regulation of EoP generation and identifies/characterizes pathways important for EoP survival, proliferation and differentiation into mature eosinophils.
    Visit the Fulkerson Lab.


    A photo of Simon P. Hogan.

    Simon P. Hogan, PhD Director of Research, Division of Allergy and Immunology

    is studying allergies, food allergies, eosinophil biology, and gastrointestinal inflammation.
    Visit the Hogan Lab.


    A photo of Leah Kottyan.

    Leah C. Kottyan, PhD

    studies the molecular and immunological mechanisms driving the statistical association of genetic variants with systemic lupus erythematosus and eosinophilic esophagitis. The goal of her research is to refine the statistical analysis of genetic data while using analytical and biological tools to predict and confirm genetic variant-dependent differences that affect gene expression, cell function, and disease risk.


    A photo of Michelle Lierl.

    Michelle B. Lierl, MD Clinical Allergist, Division of Allergy and Immunology

    researches the role of outdoor fungal and myxomycete spores as aeroallergens and is engaged in research projects related to food allergy.
    Visit Dr. Lierl’s fungal spore photo website.
    Visit the Lierl Lab website.


    A photo of Andrew W. Lindsley.

    Andrew W. Lindsley, MD, PhD

    and his lab focuses on two major research questions with significant clinical relevance; the role of sphingolipid signaling in the pathogenesis of pediatric-onset asthma and the mechanisms of humoral immune deficiency. Current B cell projects focus on the B cell defects associated with Kabuki syndrome and abnormal non-canonical NFkB signaling.


    A photo of Dr. Santa Ono.

    Santa Ono, PhD President, University of Cincinnati

    Dr. Ono's principal research interests focus on transcriptional regulation in the human immune system, mechanisms of mast-cell dependent inflammation on the ocular surface, and the immune component of age-related macular degeneration.


    A photo of Kimberly Risma.

    Kimberly A. Risma, MD, PhD Director, Allergy and Immunology Fellowship Program

    is focused on the molecular and cellular bases of primary disorders of immune deficiency and dysregulation, especially as it relates to lymphocyte cytotoxicity. She studies the pathologic consequences of missense mutations in perforin identified in patients with hemophagocytic lymphohistiocytosis (HLH) and strives to develop novel therapies through gene therapy or small molecule chaperones.
    Visit the Risma Lab website.


    A photo of Yui-Hsi Wang.

    Yui-Hsi Wang, PhD

    investigates the mechanisms that govern the plasticity of tissue resident TH2 memory / effector cells in the airway and gut. Particularly interested in understanding how inflammatory mediators, such as IL-1b, IL-33 and IL-25, regulate the development of IL-17-producing TH2 or IL-9-producing TH2 cells during airway or gastrointestinal allergic inflammation, respectively. 


    A photo of Ting Wen.

    Ting Wen, PhD Researcher, Cincinnati Center for Eosinophilic Disorders

    investigates the molecular mechanisms of eosinophilic esophagitis (EoE). His lab's studies focus on identifying novel disease-causing genes and related pathogenic pathways. His research utilizes genome-wide analysis and cutting-edge techniques to provide molecular insight into the pathogenesis of EoE and allergy. Investigating basic eosinophil biology with human samples and mouse models is also an ongoing research interest.


    A photo of Nives Zimmermann.

    Nives Zimmermann, MD Director of MS Track, Immunology Graduate Program

    focuses on deciphering mechanisms of allergic diseases, primarily asthma. Approaches include animal modeling and ex vivo cell and molecular biology. As eosinophils are the hallmark cell of allergic inflammation, including asthma, long-term goals include: 1) Understanding the mechanisms of eosinophilia and 2) Understanding the mechanisms of lung inflammation in homeostasis and allergic disease.
    Visit the Zimmermann Lab.