J. Pablo Abonia, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Immunodeficiency; mast cell progenitor homing / recruitment and its involvement in allergic disorders
Biography
J. Pablo Abonia, MD, provides the bulk of the clinical allergy care for patients with eosinophilic disease. He is currently involved in a multicenter clinical research trial of anti-IL5 (reslizumab) for patients with eosinophilic esophagitis. His research focuses on mining the research databanks (patient characteristics, tissue samples, RNA, and DNA) to elucidate the mechanisms, diagnosis and treatment of eosinophilic esophagitis. He is particularly interested in the role of mast cells in eosinophilic esophagitis.
Education and Training
MD: University of Buffalo, Buffalo, NY, 1997. Residency: Pediatrics, Children's Hospital of Buffalo, Buffalo, NY, 2000. Certification: American Board of Pediatrics, 2001; American Board of Allergy and Immunology, 2003.
Publications
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Abonia JP, Putnam PE. Mepolizumab in eosinophilic disorders. Expert Rev Clin Immunol. 2011 Jul;7(4):411-7. Debrosse CW, Franciosi JP, King EC, Buckmeier Butz BK, Greenberg AB, Collins MH, Abonia JP, Assa'ad A, Putnam PE, Rothenberg ME. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011 Jul;128(1):132-8.
Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW. Quality of life in paediatric eosinophilic oesophagitis: what is important to patients?Child Care Health Dev. 2011 Jun 15. Epub ahead of print. Abonia JP, Castells M. Drug allergy in pediatric patients. Pediatr Ann. 2011 Apr;40(4):200-4. Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7. Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3. DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9. Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.
Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2010 Aug;88(2):337-46.
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.
Grants
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Amal H. Assa'ad, MD
Director, Allergy and Immunology Fellowship Program
centers her research on food allergy and asthma. Addressing the occult effect of allergic sensitization to foods on the bronchial hyperresponsiveness in asthmatic patients and the genetic basis of food allergy. Participates in research of investigational drugs in asthma and immunodeficiencies. Working with division investigators on a translational research program that will bring basic research to the bedside in atopic and eosinophilic diseases.
513-636-6771
amal.assa'ad@cchmc.org
Amal H. Assa'ad, MD
Director, Allergy and Immunology Fellowship Program
Director, Clinical Services
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Food allergy; asthma; vaccine allergy; immunodeficiencies
Biography
Education and Training
MBBCh (MD): Ain Shams University, Cairo, Egypt 1978. MS: Ain Shams University, Cairo, Egypt, 1982. Residency: Internal Medicine/Pediatrics, Michigan State University, Hurley Medical Center, Flint, Mich.; Internal Medicine/Pediatrics, Wright State University, Dayton, Ohio, 1990-1992.
Fellowship: Allergy/Clinical Immunology, University of Texas Health Science Center, San Antonio, Texas, 1986-1987; Allergy/Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio, 1992-1995.
Certification: American Board of Internal Medicine, 1992; American Board of Pediatrics, 1992; American Board of Allergy and Immunology, 1995.
Publications
View PubMed Publications
Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3. DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9. Assa'ad A. Eosinophilic gastrointestinal disorders. Allergy Asthma Proc. 2009 Jan-Feb;30(1):17-22. Assa'ad A. Gastrointestinal eosinophil-mediated disorders and their treatment. Curr Allergy Asthma Rep. 2009 Jan;9(1):26-9.
Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, Rothenberg ME. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases.Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9. Stein ML, Villanueva JM, Buckmeier BK, Yamada Y, Filipovich AH, Assa'ad AH, Rothenberg ME. Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J Allergy Clin Immunol. 2008 Jun;121(6):1473-83, 1483.e1-4. Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, Schwartz LB, Rosenwasser LJ, Ring J, Griffin EF, Haig AE, Frewer PI, Parkin JM, Gleich GJ; Mepolizumab HES Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008 Mar 20;358(12):1215-28. Gupta J, Grube E, Ericksen MB, Stevenson MD, Lucky AW, Sheth AP, Assa'ad AH, Khurana Hershey GK. Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity. J Allergy Clin Immunol. 2008 Mar;121(3):725-730.e2.
Assa'ad A. Eosinophilic esophagitis: association with allergic disorders.Gastrointest Endosc Clin N Am. 2008 Jan;18(1):119-32; x.
Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):22-31.
Grants
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Artem Barski, PhD
Assistant Professor, Genetics and Allergy & Immunology
uses cutting-edge genomic technologies (such as ChIP-Seq and RNA-Seq) to understand contribution of epigenetic mechanisms and polymerase stalling to T cell activation, differentiation and to formation of T cell memory.
513-636-1851
artem.barski@cchmc.org
Artem Barski, PhD
Assistant Professor, Genetics and Allergy & Immunology
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Epigenetics; epigenomics; immunology; T cell memory
Biography
Artem Barski, PhD, is interested in epigenetic and transcriptional regulation of gene expression. During his post-doctoral training, Dr. Barski took part in the development of ChIP-Seq, a revolutionary method that combines ChIP with the next-generation Solexa sequencing. ChIP-Seq allows genome-wide mapping of chromatin modifications and transcription factor binding sites with resolution and sensitivity far exceeding older methods. Dr. Barski used this approach to map more than 40 chromatin modifications in human T cells, which fundamentally improved the understanding of epigenetic regulation of transcription. Dr. Barski has since been using ChIP-Seq and other sequencing-based genome-wide methods to understand the role of chromatin modifications in gene regulation. His most recent work includes investigation of chromatin regulation of genes transcribed by polymerase III and the discovery of gene poising in T cells.
Education and Training
BS/MS: Moscow State University, Department of Chemistry, Moscow, Russia, 2000.
PhD: University of Southern California, Los Angeles, CA, 2006.
Fellowship: National Institutes of Health (NIH), National Heart Lung, and Blood Institute (NHLBI), Bethesda, MD, 2011.
Publications
Barski A, Chepelev I, Liko D, Cuddapah S, Fleming AB, Birch J, Cui K, White RJ, Zhao K. Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol. 2010 May;17(5):629-34.
Cuddapah S, Barski A, Zhao K. Epigenomics of T cell activation, differentiation, and memory. Curr Opin Immunol. 2010 Jun;22(3):341-7. Cuddapah S, Barski A, Cui K, Schones DE, Wang Z, Wei G, Zhao K. Native chromatin preparation and Illumina/Solexa library construction. Cold Spring Harb Protoc. 2009 Jun;2009(6):pdb.prot5237.
Barski A, Jothi R, Cuddapah S, Cui K, Roh TY, Schones DE, Zhao K. Chromatin poises miRNA- and protein-coding genes for expression. Genome Res. 2009 Oct;19(10):1742-51 Barski A, Zhao K. Genomic location analysis by ChIP-Seq. J Cell Biochem. 2009 May 1;107(1):11-8.
Jothi R, Cuddapah S, Barski A, Cui K, Zhao K. Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res. 2008 Sep;36(16):5221-31.
Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, Cui K, Roh TY, Peng W, Zhang MQ, Zhao K. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet. 2008 Jul;40(7):897-903
Schones DE, Cui K, Cuddapah S, Roh TY, Barski A, Wang Z, Wei G, Zhao K. Dynamic regulation of nucleosome positioning in the human genome. Cell. 2008 Mar 7;132(5):887-98.
Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I, Zhao K. High-resolution profiling of histone methylations in the human genome. Cell. 2007 May 18;129(4):823-37.
Barski A, Frenkel B. ChIP Display: novel method for identification of genomic targets of transcription factors. Nucleic Acids Res. 2004 Jul 13;32(12):e104.
Grants
Role of chromatin and gene poising in T cell differentiation and activation. Principal Investigator. National Institutes of Health. 2009 - 2004. #1K22HL098691-01.
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Simon P. Hogan, PhD
Director of Admissions, Immunobiology Graduate Program
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Allergies; food allergies; eosinophil biology; gastrointestinal inflammation Visit the Hogan Lab.
Biography
Education and Training
BSC: Australian National University, Canberra, Australia, 1998.
PhD: John Curtin School of Medical Research, Australian National University, Canberra, Australia, 1998.
Publications
View PubMed Publications
Munitz A, Cole ET, Beichler A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology. 2010 Aug;139(2):530-41. Osterfeld H, Ahrens R, Strait R, Finkelman FD, Renauld JC, Hogan SP. Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis. J Allergy Clin Immunol. 2010 Feb;125(2):469-476.e2. Finkelman FD, Hogan SP, Hershey GK, Rothenberg ME, Wills-Karp M. Importance of cytokines in murine allergic airway disease and human asthma. J Immunol. 2010 Feb 15;184(4):1663-74. Review. Groschwitz KR, Ahrens R, Osterfeld H, Gurish MF, Han X, Abrink M, Finkelman FD, Pejler G, Hogan SP. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22381-6. Herbert DR, Yang JQ, Hogan SP, Groschwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban JF Jr, Rothenberg ME, Finkelman FD. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med. 2009 Dec 21;206(13):2947-57. Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 2009 Jul;124(1):3-20; quiz 21-2. Review. Munitz A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation. J Immunol. 2009 Feb 15;182(4):2357-63. Hogan SP. Functional role of eosinophils in gastrointestinal inflammation. Immunol AllergyClin North Am. 2009 Feb;29(1):129-40, xi. Review. Munitz A, Waddell A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis. J Allergy Clin Immunol. 2008 Dec;122(6):1200-1207.e1. Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008 Nov 15;181(10):7390-9.
Grants
Interleukin-9 in Experimental Intestinal Anaphylaxis. Principal Investigator. National Institute of Health. Dec 2007 - Nov 2012. #NIH RO1 A1073553-01.
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Michelle B. Lierl, MD
Clinical Allergist
Academic Information
UC Department of Pediatrics
Adjunct Associate Professor of Clinical Pediatrics
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Specialties
Clinical InterestsPeriodic fever with aphthous stomatitis; Pharangytis and Cervical Adenitis Syndrome (PFAPA); treatment and prevention of asthma; allergic rhinitis; eczema; food allergy; anaphylaxis; suspected immune deficiency Research InterestsRole of environmental allergen and pollutants in childhood asthma; asthma pathogenisis and treatment; inflammatory processes in Pharangytis and Cervical Adenitis Syndrome (PFAPA); response of PFAPA to treatment with Singulair (montelukast)
Biography
Michelle B. Lierl, MD, is board-certified in Pediatrics, Pediatric Pulmonary Medicine and Allergy / Immunology. Dr. Lierl's primary clinical interests are diagnosis and treatment of asthma, allergic rhinitis, chronic cough, food, latex, insect venom and drug allergies, and eczema. Dr. Lierl has been treating allergy patients in the Allergy and Asthma Clinic, which provides state-of-the-art diagnosis and treatment of asthma and allergies, as well as comprehensive patient education regarding these diseases. She has developed community outreach and patient / family education programs for urban children with asthma and their families. Dr. Lierl also helps staff the Allergy inpatient service, which provides consultation for the management of patients with difficult-to-manage asthma, suspected drug allergies, anaphylaxis, or suspected immune deficiency.
Education and Training
MD: University of Kentucky College of Medicine, Lexington, KY, 1979.
Residency: University of Kentucky Medical Center, Lexington, KY, 1979 to 1982.
Fellowship: Pediatric Pulmonary Medicine, Louisiana State University Medical Center, Shreveport, LA, 1984 - 1986; Allergy / Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986 - 1988.
Certification: Pediatrics, 1984; Allergy / Immunology, 1987; Pediatric Pulmonary, 1989, 1996, 2002.
Publications
View PubMed Publications
Spanier AJ, Kahn RS, Hornung RW, Wang N, Sun G, Lierl MB, Lanphear BP. Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children.Pediatr Pulmonol. 2009 Aug;44(8):812-9. Spanier AJ, Hornung RW, Kahn RS, Lierl MB, Lanphear BP. Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma.Pediatr Pulmonol. 2008 Jun;43(6):576-83. Lierl M. Periodic fever syndromes: a diagnostic challenge for the allergist.Allergy. 2007 Dec;62(12):1349-58. Review. Spanier AJ, Hornung R, Lierl M, Lanphear BP. Environmental exposures and exhaled nitric oxide in children with asthma.J Pediatr. 2006 Aug;149(2):220-6. Lierl MB, Hornung RW. Relationship of outdoor air quality to pediatric asthma exacerbations. Ann Allergy Asthma Immunol. 2003 Jan;90(1):28-33. Lierl MB. Isolated late cutaneous reactions to allergen skin testing in children. Ann Allergy Asthma Immunol. 2000 Mar;84(3):294-8. Assa'ad A, Lierl M. Effect of acellular pertussis vaccine on the development of allergic sensitization to environmental allergens in adults.J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):170-5. Alibrahim A, Lepore M, Lierl M, Filipovich A, Assaád A. Pneumocystis carinii pneumonia in an infant with X-linked agammaglobulinemia.J Allergy Clin Immunol. 1998 Apr;101(4 Pt 1):552-3. Assa'ad AH, Ballard ET, Sebastian KD, Loven DP, Boivin GP, Lierl MB. Effect of superoxide dismutase on a rabbit model of chronic allergic asthma. Ann Allergy Asthma Immunol. 1998 Mar;80(3):215-24. Yassin MS, Lierl MB, Fischer TJ, O'Brien K, Cross J, Steinmetz C. Latex allergy in hospital employees.Ann Allergy. 1994 Mar;72(3):245-9.
Grants
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Anil Mishra, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Pulmonary and esophageal inflammationl; eosinophilic esophagitis; aeroallergen-induced allergic responses in the lung and gastrointestinal tract
Biography
Anil Mishra, PhD, scientific objective includes elucidating the mechanism for the recruitment of inflammatory cells into the mucosal allergic tissue. Dr. Mishra is actively involved in managing a research program focused on understanding the molecular mechanisms of eosinophilic esophageal and lower gastrointestinal tract inflammation. Dr. Mishra's important contribution was to establish that eosinophils are the resident cell that home prenatally in the gastrointestinal tract and the gastrointestinal tract (esophagus to colon) constitutively expresses eotaxin (an eosinophil selective chemoattractant). These finding indicated that the esophagus is devoid of resident eosinophils at baseline and eotaxin is not sufficient for eosinophil trafficking and homing into the tissues. In an effort to further understand the mechanisms and significance of eosinophil accumulation in the lung and esophagus at disease states, Dr. Mishra prioritized his research to focus on lung inflammation associated eosinophilic esophagitis, aiming to gain insight into this poorly understood disease. He developed a murine model of asthma associated eosinophilic esophagitis. These findings implicated aeroallergens in the etiology of EE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation. Recently, Dr. Mishra showed that CD4 T cells dependency is less important in the esophageal eosinophilic inflammation compared to the lung and IL-5 induced esophageal eosinophilia promotes tissue remodeling. Dr. Mishra's is an elected fellow of the American Academy of Allergy, Asthma and Immunology and the American Association of Gastroenterology. He has over a 50 articles on molecular mechanisms of the pulmonary toxicity and allergic responses. His research has been supported by the National Institutes of Health to understand the mechanism that induce eosinophilic esophagitis.
Education and Training
PhD: Kanpur University, Kanpur, India.
Publications
View PubMed Publications
Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2010 Aug;88(2):337-46. Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010 Jul;139(1):182-93.e7. Zhu X, Wang M, Crump CH, Mishra A. An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis in mice. Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G550-8. Mishra A. Mechanism of eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009 Feb;29(1):29-40, viii. Review. Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008 May;6(5):812-9. Mishra A, Wang M, Pemmaraju VR, Collins MH, Fulkerson PC, Abonia JP, Blanchard C, Putnam PE, Rothenberg ME. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008 Jan;134(1):204-14. Mishra A, Wang M, Schlotman J, Nikolaidis NM, DeBrosse CW, Karow ML, Rothenberg ME. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L305-13. Mishra A, Schlotman J, Wang M, Rothenberg ME. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2007 Apr;81(4):916-24. Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol. 2006 Jul;118(1):257-68. Akei HS, Brandt EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GK, Blanchard C, Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol. 2006 Jul;118(1):62-9.
Grants
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Terri M. Moncrief, MD
, clinical investigator, is executing a multidimensional analysis of the home environment and its effect on asthma morbidity. Her work focuses on determining the impact of single-parenthood, family routines and allergic sensitizations on asthma outcomes. This work aims to address the complex functioning of families and their ability to follow a physician’s treatment plan, including reducing triggers and reliably giving medicines.
513-636-6737
terri.moncrief@cchmc.org
Terri M. Moncrief, MD
Academic Information
Instructor, UC Department of Pediatrics
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Specialties
Allergy and immunology; asthma; underserved population
Biography
To augment her work in epidemiology, biostatistics, study design and implementation, Dr. Moncrief is nearing completion of a Master’s Program in Clinical and Translational Research at the University of Cincinnati. Her thesis work aims to critically analyze the components of the social home environment that contribute to poor asthma morbidity among disadvantaged populations in order to form clinically relevant tools for successful identification of at-risk children and institute effective intervention strategies. Dr. Moncrief gave a platform presentation at the World Allergy Congress in Mexico in 2011 on her work entitled “Prevalence of Cockroach and Mouse Sensitization among Children Hospitalized for Wheezing and Asthma”. This work was the basis for a systematic review on
“Mouse Sensitization as an Independent Risk Factor for Asthma Morbidity” which has been accepted for publication in the peer-reviewed journal “Annals of Allergy, Asthma & Immunology”. In addition, she has presented her clinical work entitled “Purified C1 Inhibitor as Pre-operative Prophylaxis in a Pediatric Patient with Hereditary Angioedema“ at the National Scientific Meeting of the American College of Asthma Allergy and Immunology (ACAAI) in 2010. She is a member of the ACAAI Adverse Food Reactions Committee.
Education and Training
MD: Washington University School of Medicine, Saint Louis, MO, 2006. Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Fellowship: Allergy & Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Certification: Pediatrics, 2009.
Publications
Moncrief T, Kahn R, Assa'ad A. Mouse Sensitization as an Independent Risk Factor for Asthma Morbidity. In press, 2011.
Grants
Single-parenthood: Increased Household Strain and Child Asthma-Related Morbidity. Principal Investigator. National Institutes of Health. Nov 2011-Oct 2012. #2 K12 HD028827.
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Ariel Munitz, PhD
Adjunct Assistant Professor, Allergy and Immunology
is focused on delineating the cellular and molecular mechanisms involved in mucosal inflammation. Goal is to identify novel immunological mechanisms that can be pharmacologically targeted in diseases affecting the lung and gastrointestinal tract using a combination of state-of-the-art in vivo and in vitro approaches that bridge the fields of genomics, proteomics, molecular biology and biochemistry. Visit the Munitz Lab
513-636-8428
ariel.munitz@cchmc.org
Ariel Munitz, PhD
Adjunct Assistant Professor, Allergy and Immunology
Senior Lecturer, Tel Aviv University
Academic Information
UC Department of Pediatrics
Adjunct Assistant Professor, Allergy and Immunology
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Specialties
Inhibitory receptors; eosinophils; asthma; eosinophilic esophagitis
Biography
Education and Training
BScMed: The Institution for Medical Studies, The Faculty of Medicine, The Hebrew University of Jerusalem, 2001.
MSc: Department of Pharmacology, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, 2002.
PhD: Department of Pharmacology, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, 2006.
Fellow: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center.
Publications
View PubMed Publications
Munitz A, Cole ET, Beichler A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.Gastroenterology. 2010 Aug;139(2):530-41. Epub 2010 Apr 14. Herbert DR, Yang JQ, Hogan SP, Groschwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban JF Jr, Rothenberg ME, Finkelman FD. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.J Exp Med. 2009 Dec 21;206(13):2947-57. Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression.J Immunol. 2009 Apr 15;182(8):4994-5002. Munitz A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation.J Immunol. 2009 Feb 15;182(4):2357-63. Munitz A, Waddell A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis.J Allergy Clin Immunol. 2008 Dec;122(6):1200-1207.e1. Brandt EB, Munitz A, Orekov T, Mingler MK, McBride M, Finkelman FD, Rothenberg ME. Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin Immunol. 2009 Jan;123(1):53-8. Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.J Immunol. 2008 Nov 15;181(10):7390-9. Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7240-5. Munitz A, McBride ML, Bernstein JS, Rothenberg ME. A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils. Blood. 2008 Jun 15;111(12):5694-703.
Grants
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Santa Ono, PhD
Professor, Allergy and Immunology
Dr. Ono's principal research interests focus on transcriptional regulation in the human immune system, mechanisms of mast-cell dependent inflammation on the ocular surface, and the immune component of age-related macular degeneration.
513-636-6771
santa.ono@cchmc.org
Santa Ono, PhD
Professor, Allergy and Immunology
Senior Vice President for Academic Affairs and University Provost, University of Cincinnati
Academic Information
Professor, UC Department of Pediatrics
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Biography
Santa J. Ono, PhD, is a professor of pediatrics at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine.
Grants
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Kimberly A. Risma, MD, PhD
is focused on the molecular and cellular bases of primary disorders of immune deficiency and dysregulation, especially as it relates to lymphocyte cytotoxicity. She studies the pathologic consequences of missense mutations in perforin identified in patients with hemophagocytic lymphohistiocytosis (HLH) and strives to develop novel therapies through gene therapy or small molecule chaperones.
513-636-6771
kimberly.risma@cchmc.org
Kimberly A. Risma, MD, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsImmune deficiency; immune dysregulation Research InterestsPathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; Molecular mechanisms of primary immune deficiency and dysregulation; Natural killer cell and cytotoxic T lymphocyte cytotoxicity
Biography
Kimberly Risma, MD, PhD, is an Assistant Professor in the Division of Allergy/Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine. Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997. In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati. During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident. In 2000, Dr. Risma was accepted to the Allergy/Immunology Fellowship at Cincinnati Children’s. In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006. Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation.
Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.
Education and Training
MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997. PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996. Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000. Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center. Certification: Pediatrics, 2007; Allergy and Immunology, 2005.
Publications
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Sumegi J, Barnes MG, Nestheide SV, Molleran-Lee S, Villanueva J, Zhang K, Risma KA, Grom AA, Filipovich AH. Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis. Blood. 2011 Apr 14;117(15):e151-60. Uygungil B, Bleesing JJ, Risma KA, McNeal MM, Rothenberg ME. Persistent rotavirus vaccine shedding in a new case of severe combined immunodeficiency: A reason to screen. J Allergy Clin Immunol. 2010 Jan;125(1):270-1. Marsh RA, Villanueva J, Kim MO, Zhang K, Marmer D, Risma KA, Jordan MB, Bleesing JJ, Filipovich AH. Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populations. Clin Immunol. 2009 Jul;132(1):116-23. Marsh RA, Villanueva J, Zhang K, Snow AL, Su HC, Madden L, Mody R, Kitchen B, Marmer D, Jordan MB, Risma KA, Filipovich AH, Bleesing JJ. A rapid flow cytometric screening test for X-linked lymphoproliferative disease due to XIAP deficiency. Cytometry B Clin Cytom. 2009 Sep;76(5):334-44.
Urrea Moreno R, Gil J, Rodriguez-Sainz C, Cela E, LaFay V, Oloizia B, Herr AB, Sumegi J, Jordan MB, Risma KA. Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function. Blood. 2009 Jan 8;113(2):338-46. Zhang K, Johnson JA, Biroschak J, Villanueva J, Lee SM, Bleesing JJ, Risma KA, Wenstrup RJ, Filipovich AH. Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects. Int J Immunogenet. 2007 Aug;34(4):231-3. Thomas H, Risma KA, Graham TB, Brody AS, Deutsch GH, Young LR, Joseph PM. A kindred of children with interstitial lung disease. Chest. 2007 Jul;132(1):221-30.
Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):22-31.
Risma KA, Frayer RW, Filipovich AH, Sumegi J. Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J Clin Invest. 2006 Jan;116(1):182-92.
Grants
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Karl F. von Tiehl, MD
centers his clinical research on the relation of egg allergy and the influenza vaccine and the role of parasites in eosinophilic gastrointestinal disorders. Involved in the clinical research projects headed by Marc Rothenberg that examine the roles of anti-IL-13 therapy and high-dose fluticasone in the treatment of eosinophilic esophagitis.
karl.von_tiehl@cchmc.org
Karl F. von Tiehl, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Drug allergy; aspirin-exacerbated respiratory disease and other eosinophilic disorders
Biography
Karl F. von Tiehl, MD, is a faculty member of the Division of Allergy & Immunology at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine. He graduated cum laude in Biology from Claremont McKenna College before matriculating at the Medical College of Ohio (now known as the University of Toledo College of Medicine). After medical school, Dr. von Tiehl completed a 3-year combined internship & residency training program in Internal Medicine at the Scripps Clinic and Scripps Green Hospital (La Jolla, CA), where he stayed on to complete a 2-year fellowship in Allergy & Immunology. His basic science research year was spent at the world-renowned Scripps Research Institute (La Jolla, CA) in the prestigious lab of Dr. Michael B.A. Oldstone, where he performed sentinel work on aspirin-exacerbated respiratory disease (AERD) and varicella zoster virus vaccination failure under Dr. Donald Stevenson, while assisting in chronic viral infection research in the mouse model. Dr. von Tiehl also remained very involved during his fellowship years in clinical trials in AERD patients and in patients with Plavix (clopidogrel) sensitivity. Dr. von Tiehl plans to begin his own clinical trials at CCHMC soon. Dr. von Tiehl is currently taking new pediatric and adult outpatients with general allergy concerns (e.g. allergic rhinitis, asthma, eczema, hives, angioedema, anaphylaxis, contact dermatitis, and food, drug, latex and venom allergies). He also provides subspecialty consultations for inpatients and for nationwide adult referral patients to the Cincinnati Center for Eosinophilic Disorders (CCED), directed by Dr. Marc Rothenberg.
Education and Training
MD: University of Toledo, Toledo, OH, 2004.
Internship, Residency: Internal Medicine, Scripps Clinic and Scripps Green Hospital, La Jolla, CA, 2004-07.
Fellowship: Allergy and Immunology, Scripps Clinic and Scripps Green Hospital, La Jolla, CA, 2007-09.
Certification: Internal Medicine, 2007-2017. Allergy and Immunology, 2009-2019.
Publications
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von Tiehl KF, Stevenson DD, Oldstone MBA. Cytokine Profiles in Aspirin-exacerbated Respiratory Disease Support the Theory of a Chronic Viral Infection. Ann Allergy Asthma Immunol. 2009. von Tiehl KF, Stevenson DD. A Case of Hydroxyurea-responsive, Non-aspirin-sensitive, Treatment-refractory, Severe, Eosinophilic Nasal Polyposis, Chronic Rhinosinusitis and Asthma. Ann Allergy Asthma Immunol. 2008. von Tiehl KF, Woessner KM, Simon RA, Stevenson DD. Characterization of Oral Aspirin Challenge-induced Extra-respiratory Reactions in Patients Suspected of Having Aspirin-exacerbated Respiratory Disease. J Allergy Clin Immunol. 2008;121(2):S194. von Tiehl KF, Price MJ, Valencia R, Ludington KJ, Teirstein PS, Simon RA. Clopidogrel desensitization after drug-eluting stent placement. J Am Coll Cardiol. 2007 Nov 20;50(21):2039-43.
Grants
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Yui-Hsi Wang, PhD
investigates the mechanisms that govern the plasticity of tissue resident TH2 memory / effector cells in the airway and gut. Particularly interested in understanding how inflammatory mediators, such as IL-1b, IL-33 and IL-25, regulate the development of IL-17-producing TH2 or IL-9-producing TH2 cells during airway or gastrointestinal allergic inflammation, respectively.
513-803-2193
yui_hsi.wang@cchmc.org
Yui-Hsi Wang, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Asthma; food allergy; T cell biology
Biography
Education and Training
PhD: University of Alabama, Birmingham, AL, 2001.
Publications
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Wang YH, Voo KS, Liu B, Chen CY, Uygungil B, Spoede W, Bernstein JA, Huston DP, Liu YJ. A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J Exp Med. 2010 Oct 25;207(11):2479-91. Shaw J, Wang YH, Ito T, Arima K, Liu YJ. Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70. Blood. 2010 Apr 15;115(15):3051-7.
Wang YH, Liu YJ. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin Exp Allergy. 2009 Jun;39(6):798-806.
Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, Bover L, Hanabuchi S, Khalili J, Marinova E, Zheng B, Littman DR, Liu YJ. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4793-8.
Lu N, Wang YH, Wang YH, Arima K, Hanabuchi S, Liu YJ. TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis. J Exp Med. 2009 Sep 28;206(10):2111-9.
Esashi E, Wang YH, Perng OA, Qin XF, Hennighausen L, Liu YJ, Watowich SS. Differential regulation of plasmacytoid and conventional dendritic cell development by GM-CSF through STAT5. Immunity. 2008;28:1-12.
Wang YH, Liu YJ. The IL-17 cytokine family and their role in allergic inflammation. Curr Opin Immunol. 2008 Dec;20(6):697-702.
Wang YH, Liu YJ. OX40-OX40L interactions: a promising therapeutic target for allergic diseases?J Clin Invest. 2007 Dec;117(12):3655-7. Wang YH, Angkasekwinai P, Meng Q, Lu N, Voo KS, Arima K, Hanabuchi S, Corrigan CG, Lee T, Dong C, Huston DR, Yao Z, Ying S, and Liu YJ. IL-25 mediated cross talk between eosinophils and TSLP-DC-activated TH2 memory cells augments allergic immune responses. J. Exp. Med. 2007;204(8): 1837-1847.
Ito T, Wang YH, Duramad O, Hanabuchi S, Perng OA, Gilliet M, Qin FX, Liu YJ. OX40 ligand shuts down IL-10-producing regulatory T cells. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13138-43.
Grants
The roles of IL-17-producing TH2 memory/effector cells in allergic asthma. Principal Investigator. American Lung Association. July 2010 - June 2012. #AI-169584-N. Regulation and maintenance of TH2 memory/effector cells. Principal Investigator. National Institutes of Health. May 2010- April 2015. #R01AI090129-01.
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Nives Zimmermann, MD
Director of MS Program
focuses on deciphering mechanisms of allergic diseases, primarily asthma. Approaches include animal modeling and ex vivo cell and molecular biology. As eosinophils are the hallmark cell of allergic inflammation, including asthma, long-term goals include: 1) Understanding the mechanisms of eosinophilia and 2) Understanding the mechanisms of lung inflammation in homeostasis and allergic disease. Visit the Zimmermann Lab
513-636-3887
zimmn0@cchmc.org
Nives Zimmermann, MD
Director of MS Program
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Biography
Education and Training
MD: School of Medicine, University of Zagreb; Zagreb, Croatia, 1995.
Publications
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Niese KA, Collier AR, Hajek AR, Cederbaum SD, O'Brien WE, Wills-Karp M, Rothenberg ME and Zimmermann N. Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC Immunology. 2009;10:33. Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey G, Rothenberg ME, Zimmermann N. Eosinophil viability is increased by acidic pH in a cAMP and GPR65-dependent manner. Blood. 2009; 14(13):2774-82. Zimmermann N, McBride ML, Yamada Y, Hudson SA, Jones C, Cromie KD, Crocker PR, Rothenberg ME, Bochner BS. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy. 2008;63:1156-63. Bergeron C, Boulet LP, Page N, Laviolette M, Zimmermann N, Rothenberg ME, Hamid Q. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. J Allergy Clin Immunol. 2007;119:391-7. Guo JP, Nutku E, Yokoi H, Schnaar RL, Zimmermann N, Bochner BS. Siglec-8 and Siglec-F: inhibitory receptors on eosinophils, basophils and mast cells.Allergy Clin Immunol Inter – J World Allergy Org. 2007;19:54-59. Brandt EB, Zimmermann N, Muntel EE, Yamada Y, Pope SM, Mishra A, Hogan SP, Rothenberg ME. The alpha4beta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine. Clin Exp Allergy. 2006; 36(4):543-53. Zimmermann N, Rothenberg ME. The arginine-arginase balance in asthma and lung inflammation. Eur J Pharmacol. 2006;533(1-3):253-62 Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG and Zimmermann N. The cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci USA. 2006;103:14895 Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmermann N, Mahalingam S, Webb DC, Tremethick DJ, Thompson PJ, Hogan SP, Rothenberg ME, Cowden WB, Foster PS. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J Immunol. 2006;177:5595-603. Fulkerson PC, Zhu H, Williams DA, Zimmermann N, Rothenberg ME. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. Blood. 2005;106(2):436-43.
Grants
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Li Zuo, MD, MSc
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsFood allergy; eosinophilic esophagitis; asthma Research InterestsMechanism and the new therapeutic options for food allergy, including eosinophilic esophagitis
Biography
Education and Training
MD: Zunyi Medical College, Guizhou, China, 1982. Residency: Pediatrics, University of Toledo Medical Center, Toledo, Ohio, 2005. Fellowship: Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2007. Certifications: American Board of Pediatrics, American Board of Allergy and Immunology, 2011.
Publications
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Zuo L, Fulkerson PC, Finkelman FD, Mingler M, Fischetti CA, Blanchard C, Rothenberg ME. IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway. J Immunol. 2010 Jul 1;185(1):660-9. Zuo L, Rothenberg ME. Eosinophil Associated Gastrointestinal Disorders (EGID). Clinical Immunology. 2008;46:691-700.
Zuo L, Rothenberg ME. Gastrointestinal eosinophilia. Immunol Allergy Clin North Am. 2007 Aug;27(3):443-55. Review. Book ChaptersDeBrosse CW, Zuo L. Eosinophilic Enteritis. In Stefano Guandalini and Haleh Vaziri (eds): Diarrhea: Diagnostic and Therapeutic Advances. Humana Express: New York, NY, 2010.
Grants
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