Allergy and Immunology

  • Research Faculty

    Our research spans fundamental studies, translational investigation and clinical trials. Novel models of immunological diseases, developed and/or fine-tuned by divisional researchers, provide unprecedented systems to investigate key inflammatory steps involved in pediatric allergic and immunological disease and to enhance our understanding of mast cells, eosinophils, macrophages and lymphocytes. Our integrative laboratories are led by nationally recognized researchers and employ state-of-the-art model systems for genetic, biochemical, immunological and physiological analysis.

    Read more about our faculty's research below.

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    Division Head

    A photo of Marc Rothenberg, MD, PhD.

    Marc E. Rothenberg, MD, PhD Director, Division of Allergy and Immunology

    is focused on elucidating mechanisms of allergic responses, especially in mucosal tissues such as the lung and the gastrointestinal tract, in order to identify novel pharmaceutical targets for treatment of patients with eosinophilic diseases including eosinophilic gastrointestinal disorders, hypereosinophilic syndromes and asthma and food allergies. Lab has identified and characterized several critical pathways that regulate allergic responses. 

    Visit the Rothenberg Lab website

    513-803-0257
    marc.rothenberg@cchmc.org

    Marc E. Rothenberg, MD, PhD

    Director, Division of Allergy and Immunology

    Director, Cincinnati Center for Eosinophilic Disorders

    Program Director, CHRCDA (K12)

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-803-0257

    Fax: 513-636-3310

    Email: marc.rothenberg@cchmc.org

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    Specialties

    Clinical Interests

    Eosinophilia; eosinophilic disorders; asthma; allergy; food allergy

    Research Interests

    Eosinophils; chemokines

    Visit the Rothenberg Lab.

    Biography

    Marc E. Rothenberg, MD, PhD, is the Director of the Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center, and a tenured Professor of Pediatrics at Cincinnati Children’s and the University of Cincinnati College of Medicine. He graduated summa cum laude with Highest Honors in Chemistry and Biochemistry from Brandeis University. He then matriculated at Harvard Medical School in the combined MD / PhD program. His PhD under the mentorship of Dr. Frank Austen included seminal studies on eosinophil hematopoiesis, as he developed the first culture system for human eosinophils.

    After completing a two-year residency in pediatrics at Children’s Hospital in Boston, Dr. Rothenberg did a combined fellowship in allergy / immunology and hematology at Children’s Hospital in Boston. During this fellowship program, Dr. Rothenberg did post-doctorate training in the genetics laboratory of Dr. Philip Leder at Harvard Medical School, where he cloned the eotaxin chemokine. After being on faculty of Harvard Medical School for one year, he came to the University of Cincinnati and Cincinnati Children's, one of the largest pediatric medical and research centers in the United States. He is actively involved in managing a research program focused on understanding the molecular mechanisms of allergic disorders. At Cincinnati Children’s, he has helped build a top program in pediatric research, and his division is a leader in pediatric allergy and immunology. In addition, he sees patients suffering from allergic and immunological diseases from around the world as part of the Cincinnati Center for Eosinophilic Disorders that he directs.

    Dr. Rothenberg’s awards include the Pharmacia Allergy Research Foundation Award for the best young investigator in the allergy field; the Young Investigator Award and the Scholar in Allergy Award from the American Academy of Allergy, Asthma, and Immunology; the Ohio Governor’s Recognition Award; the 2007 E Mead Johnson Award from the Society of Pediatric Research; and an NIH MERIT Award in 2010 from the NIAID. He is an elected member of the American Society of Clinical Investigation, Society for Pediatric Research, and a Diplomate of the American Academy of Allergy, Asthma and Immunology.

    Among his extensive publications of more than 250 articles on molecular mechanisms of allergic responses, Dr. Rothenberg edited a book entitled, “Chemokines in Allergic Disease”. He has served on various review panels for journals and grant agencies including the National Institutes of Health, where he served on the Advisory Council of the NIAID, Burroughs Trust, and the Medical Research Council of the UK. His research has been supported by numerous sources including the National Institutes of Health, the USA Department of Defense, Human Frontier Science Program Organization, the Burroughs Wellcome Fund, the Dana Foundation, and the Food Allergy and Anaphylaxis Network.

    Visit the Rothenberg Lab website

    Education and Training

    MD, PhD: Harvard Medical School, Cambridge, MA, 1990.

    Residency: Pediatrics, Children's Hospital, Boston, MA, 1991-1992.

    Fellowship: Immunology / Allergy, Children's Hospital, Boston, MA, 1992-1994; Hematology / Oncology, Children's Hospital and Dana Farber Cancer Institute, Boston, MA, 1992-1995.

    Certification: National Board of Medical Examiners, 1991; Board of Registration in Medicine, MA, 1992; American Board of Pediatrics, 1995, 2001, 2008; Ohio State Medical Board, 1997; American Board of Allergy and Immunology, 1997, 2006.

    Publications

    Grants

    NICHHD Pediatric Center for Gene Expression and Developmental Sciences. Program Director. National Institutes of Health. 2007-2011. K12 HD028827.

    IL-13 and Eosinophilic Esophagitis. Principal Investigator. National Institutes of Health.  2007-2012. R01 DK076893.

    Genetics of Eosinophilic Esophagitis. Principal Investigator. Department of Defense. 2010-2012. DOD W81XWH1010167. 

    Resistin-like Molecules in the Lung. Co-Principal Investigator. US-Israel Binational Science Foundation. 2010-2012. #2009222. 

    IL-13 Associated Eosinophil Lung Responses. Principal Investigator. National Institutes of Health. 2009-2014. R01 AI083450.

    Regulation of Gastrointestinal Eosinophils. Principal Investigator. National Institutes of Health. 2009-2014. R37 AI045898. 

    Faculty

    A photo of J. Pablo Abonia.

    J. Pablo Abonia, MD Interim Director, Registry for Eosinophilic Disorders (REGID)

    assesses the biology and regulation of mast cells and their role in disease such as eosinophilic esophagitis and primary mast cell disease. Conducting translational research and clinical trials and developing patient databanks and bioinformatic approaches to understanding allergic disease. Sees patients at the Cincinnati Center for Eosinophilic Disorders. Involved in the national Registry for Eosinophilic Gastrointestinal Disorders (REGID).

    513-636-9463
    pablo.abonia@cchmc.org

    J. Pablo Abonia, MD

    Interim Director, Registry for Eosinophilic Disorders (REGID)

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-9463

    Fax: 513-636-3310

    Email: pablo.abonia@cchmc.org

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    Specialties

    Eosinophilic and mast cell disorders; immunodeficiency

    Biography

    J. Pablo Abonia, MD, provides the bulk of the clinical allergy care for patients with eosinophilic disease. He is currently involved in a multicenter clinical research trial of anti-IL5 (reslizumab) for patients with eosinophilic esophagitis. His research focuses on mining the research databanks (patient characteristics, tissue samples, RNA and DNA) to elucidate the mechanisms, diagnosis and treatment of eosinophilic esophagitis, and he is the Interim Director of the Registry for Eosinophilic Disorders (REGID). He is particularly interested in the role of mast cells in eosinophilic esophagitis.

    Education and Training

    MD: University of Buffalo, Buffalo, NY, 1997.

    Residency: Pediatrics, Children's Hospital of Buffalo, Buffalo, NY, 2000.

    Certification: American Board of Pediatrics, 2001; American Board of Allergy and Immunology, 2003.

    Publications

    View PubMed Publications
    A photo of Amal Assa'Ad.

    Amal H. Assa'ad, MD Associate Director, Division of Allergy and Immunology

    centers her research on food allergy and asthma. Addressing the occult effect of allergic sensitization to foods on the bronchial hyperresponsiveness in asthmatic patients and the genetic basis of food allergy. Participates in research of investigational drugs in asthma and immunodeficiencies. Working with division investigators on a translational research program that will bring basic research to the bedside in atopic and eosinophilic diseases.

    513-636-6771
    amal.assa'ad@cchmc.org

    Amal H. Assa'ad, MD

    Associate Director, Division of Allergy and Immunology

    Director of Clinical Services, Division of Allergy and Immunology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-6771

    Fax: 513-636-4615

    Email: amal.assa'ad@cchmc.org

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    Specialties

    Food allergy; asthma; vaccine allergy; immunodeficiencies

    Education and Training

    MBBCh (MD): Ain Shams University, Cairo, Egypt 1978.

    MS: Ain Shams University, Cairo, Egypt, 1982.

    Residency: Internal Medicine/Pediatrics, Michigan State University, Hurley Medical Center, Flint, Mich.; Internal Medicine/Pediatrics, Wright State University, Dayton, Ohio, 1990-1992.

    Fellowship:
    Allergy/Clinical Immunology, University of Texas Health Science Center, San Antonio, Texas, 1986-1987; Allergy/Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio, 1992-1995.

    Certification:
    American Board of Internal Medicine, 1992; American Board of Pediatrics, 1992; American Board of Allergy and Immunology, 1995.

    Publications

    View PubMed Publications
    A photo of Dr. Artem Barski.

    Artem Barski, PhD

    uses cutting-edge genomic technologies (such as ChIP-Seq and RNA-Seq) to understand contribution of epigenetic mechanisms and polymerase stalling to T cell activation, differentiation and to formation of T cell memory.
    Visit the Barski Lab

    513-636-1851
    artem.barski@cchmc.org

    Artem Barski, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-1851

    Email: artem.barski@cchmc.org

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    Specialties

    Epigenetics; epigenomics; immunology; T cell memory

    Visit the Barski Lab

    Biography

    Artem Barski, PhD, is interested in epigenetic and transcriptional regulation of gene expression. During his post-doctoral training in Keji Zhao lab at NIH, Dr. Barski took part in the development of ChIP-Seq, a revolutionary method that combines ChIP with the next-generation sequencing. ChIP-Seq allows genome-wide mapping of chromatin modifications and transcription factor binding sites with resolution and sensitivity far exceeding older methods. Together with his NIH colleagues Dr. Barski used this approach to map more than 40 chromatin modifications in human T cells, which fundamentally improved the understanding of epigenetic regulation of transcription. Dr. Barski has since been using ChIP-Seq and other sequencing-based genome-wide methods to understand the role of chromatin modifications in gene regulation. His most recent work includes investigation of chromatin regulation of genes transcribed by RNA Polymerase III and the discovery of gene poising in T cells.

    Since his arrival to Cincinnati Children’s Hospital Medical Center in 2011, Dr. Barski is utilizing ChIP-Seq, RNA-Seq and other cutting-edge approaches to understand epigenetic basis of T cell activation, memory and tolerance.

    Education and Training

    BS/MS: Moscow State University, Department of Chemistry, Moscow, Russia, 2000.

    PhD: University of Southern California, Los Angeles, CA, 2006.

    Fellowship: National Institutes of Health (NIH), National Heart Lung, and Blood Institute (NHLBI), Bethesda, MD, 2011.

    Publications

    A photo of Patricia Fulkerson.

    Patricia C. Fulkerson, MD, PhD

    researches the biology of the eosinophil-lineage committed progenitor (EoP). Aiming to identify novel therapeutic targets to block eosinophil production for the treatment of patients with eosinophilic disorders, she investigates transcriptional regulation of EoP generation and identifies/characterizes pathways important for EoP survival, proliferation and differentiation into mature eosinophils.
    Visit the Fulkerson Lab website.

    513-803-0973
    patricia.fulkerson@cchmc.org

    Patricia C. Fulkerson, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-0973

    Email: patricia.fulkerson@cchmc.org

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    Specialties

    Eosinophilic disorders; immunodeficiency; immune dysregulation

    Visit the Fulkerson Lab website.

    Biography

    Patricia C. Fulkerson, MD, PhD, is an assistant professor of pediatrics at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine.  Her PhD under the mentorship of Dr. Marc Rothenberg was focused on the analysis of experimental allergic lung inflammation in mice. She made a series of groundbreaking observations including a novel approach to understanding the complex and coordinated interplay of the chemokine family of cytokines and eosinophils in experimental allergic lung disease. Throughout her graduate studies, Dr. Fulkerson was recognized as a top trainee in the laboratory. Nationally, she was selected for competitive awards; her most distinguished award was the Serono Ian Clark-Lewis Memorial Award, provided to a trainee for the best talk at the Keystone Symposium Chemokines & Chemokine Receptors. Locally, she has received several competitive awards and scholarships including the Physician Scientist Training Program Scholar Award, as well as prizes for participation in research forums. Upon completion of the MD/PhD program, Dr. Fulkerson completed a research-track pediatric residency. She was recognized as being an outstanding resident and was awarded the Thomas F. Boat Pediatric Pulmonology Award in her final year of residency.

    Dr. Fulkerson's innovation and dedication to research continued to be recognized during her allergy/immunology fellowship; she received the AAI-Life Technologies Trainee Achievement Award from the American Association of Immunologists in 2011, and she has the distinction of having achieved extramural funding during her first year of clinical fellowship, with the NIH awarding her a K08 grant on her first application. This independent funding at such an early stage is a notable accomplishment. Now, as an assistant professor, Dr. Fulkerson’s independent research program is focused on the biology of the eosinophil lineage-committed progenitor (EoP). Her overall aim is to identify novel therapeutic targets to block eosinophil production for the treatment of patients with eosinophilic disorders. She has developed a number of innovative methods to study the regulation of eosinophil development including liquid culture systems to follow differentiation of both murine and human EoPs into mature effector eosinophils. The pathways that are identified in her culture systems are tested in models of hypereosinophilia, infection, and allergic inflammation to further characterize the clinical and therapeutic potential of candidate targets.

    Education and Training

    MD: Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, 2007.

    PhD: Molecular Genetics, Microbiology & Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, 2005.

    Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010.

    Fellowship: Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012.

    Publications

    View PubMed Publications

    Grants

    Role of Spi-C in Eosinophil Development and Functional Responses. Principal Investigator. National Institutes of Health. Apr 2011-Mar 2016. K08 KAI093573A.
    A photo of Simon P. Hogan.

    Simon P. Hogan, PhD Director of Research, Division of Allergy and Immunology

    is studying allergies, food allergies, eosinophil biology & gastrointestinal inflammation.
    Visit the Hogan Lab.

    513-636-6620
    simon.hogan@cchmc.org

    Simon P. Hogan, PhD

    Director of Research, Division of Allergy and Immunology

    Director of Admissions, Immunology Graduate Program

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-6620

    Fax: 513-636-3310

    Email: simon.hogan@cchmc.org

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    Specialties

    Food allergies and anaphylaxis; inflammatory bowel diseases (IBD); innate immunity; gastrointestinal immunity and function; cystic fibrosis (CF)

    Visit the Hogan Lab.

    Education and Training

    BSC: Australian National University, Canberra, Australia, 1998.

    PhD: John Curtin School of Medical Research, Australian National University, Canberra, Australia, 1998.

    Publications

    View PubMed Publications

    Grants

    MiR-375 regulation of CFTR expression and Cl- secretory function. Principal Investigator. Cystic Fibrosis Foundation. Jul 2012-Jun 2014.

    Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric Corticosteroid Resistant UC. Principal Investigator.  National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK). Apr 2012-Mar 2016.

    Epithelial Genes in Allergic Inflammation. Project 2 – Collaborating Investigator. National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAIDS). Sep 2006-Aug 2016.

    Interleukin-9 in Experimental Intestinal Anaphylaxis. Principal Investigator. National Institutes of Health/ National Institute of Allergy and Infectious Diseases/ National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIAIDS/NIDDK). Dec 2007-Nov 2013.

    A photo of Michelle Lierl.

    Michelle B. Lierl, MD Clinical Allergist, Division of Allergy and Immunology

    researches the role of outdoor fungal and myxomycete spores as aeroallergens and is engaged in research projects related to food allergy.
    Visit Dr. Lierl’s Fungal Spore Photo Website.
    Visit the Lierl Lab website.

    513-636-6771
    michelle.lierl@cchmc.org

    Michelle B. Lierl, MD

    Clinical Allergist, Division of Allergy and Immunology

    Academic Information

    UC Department of Pediatrics

    Adjunct Professor of Clinical Pediatrics

    Phone: 513-636-6771

    Fax: 513-636-4615

    Email: michelle.lierl@cchmc.org

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    Specialties

    Clinical Interests

    Treatment and prevention of asthma; allergic rhinitis; allergen immunotherapy; eczema; food allergy; anaphylaxis; suspected immune deficiency

    Research Interests

    Role of environmental allergens and pollutants in childhood asthma; allergen immunotherapy; asthma pathogenesis and treatment; role of outdoor fungal spores as aeroallergens; diagnosis and treatment of food allergy

    Visit Dr. Lierl's fungal spore photo website.

    Visit the Lierl Lab website.

    Biography

    Michelle B. Lierl, MD, is board-certified in Pediatrics, Pediatric Pulmonary Medicine and Allergy / Immunology. Dr. Lierl's primary clinical interests are diagnosis and treatment of asthma, allergic rhinitis, chronic cough, food, latex, insect venom and drug allergies, and eczema.

    Dr. Lierl has been treating allergy patients in the Allergy Clinic and Asthma Center, which provides state-of-the-art diagnosis and treatment of asthma and allergies, as well as comprehensive patient education regarding these diseases. She has developed community outreach and patient / family education programs for urban children with asthma and their families.

    Dr. Lierl also helps staff the Allergy inpatient service, which provides consultation for the management of patients with difficult-to-manage asthma, suspected drug allergies, anaphylaxis, or suspected immune deficiency.

    Education and Training

    MD: University of Kentucky College of Medicine, Lexington, KY, 1979.

    Residency: University of Kentucky Medical Center, Lexington, KY, 1979 to 1982. 

    Fellowship: Pediatric Pulmonary Medicine, Louisiana State University Medical Center, Shreveport, LA, 1984 - 1986; Allergy / Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986 - 1988. 

    Certification: Pediatrics, 1984; Allergy / Immunology, 1987; Pediatric Pulmonary, 1989, 1996, 2002.

    Publications

    View PubMed Publications
    A photo of Dr. Santa Ono.

    Santa Ono, PhD Professor, Division of Allergy and Immunology

    Dr. Ono's principal research interests focus on transcriptional regulation in the human immune system, mechanisms of mast-cell dependent inflammation on the ocular surface, and the immune component of age-related macular degeneration.

    513-636-6771
    santa.ono@cchmc.org

    Santa Ono, PhD

    Professor, Division of Allergy and Immunology

    President, University of Cincinnati

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-6771

    Email: santa.ono@cchmc.org

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    Biography

    Santa J. Ono, PhD, is a professor of pediatrics at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine.
    A photo of Kimberly Risma.

    Kimberly A. Risma, MD, PhD Director, Allergy and Immunology Fellowship Program

    is focused on the molecular and cellular bases of primary disorders of immune deficiency and dysregulation, especially as it relates to lymphocyte cytotoxicity. She studies the pathologic consequences of missense mutations in perforin identified in patients with hemophagocytic lymphohistiocytosis (HLH) and strives to develop novel therapies through gene therapy or small molecule chaperones.
    Visit the Risma Lab website.

    513-636-6771
    kimberly.risma@cchmc.org

    Kimberly A. Risma, MD, PhD

    Director, Allergy and Immunology Fellowship Program

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-6771

    Fax: 513-636-4615

    Email: kimberly.risma@cchmc.org

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    Specialties

    Clinical Interests

    Immune deficiency; immune dysregulation

    Research Interests

    Pathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; molecular mechanisms of primary immune deficiency and dysregulation; natural killer cell and cytotoxic T lymphocyte cytotoxicity

    Visit the Risma Lab website.

    Biography

    Kimberly Risma, MD, PhD, is an assistant professor in the Division of Allergy and Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine.

    Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997.

    In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati.  During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident.

    In 2000, Dr. Risma was accepted to the Allergy and Immunology Fellowship Program at Cincinnati Children’s.  In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006.  

    Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. Dr. Risma is the director of the Allergy and Immunology Fellowship Program at Cincinnati Children's, having served in this leadership position since August of 2012.

    Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.   

    Education and Training

    MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997.

    PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000.

    Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center.

    Certification: Pediatrics, 2007; Allergy and Immunology, 2005.

    Publications

    View PubMed Publications
    A photo of Joseph Sherrill.

    Joseph D. Sherrill, PhD

    is a molecular geneticist who has a diverse research background in microbiology, immunology and genetics. His current research employs a functional genomics approach to understand the genetic etiology of inflammatory diseases such as eosinophilic gastrointestinal disorders. In particular, his lab is focused on the discovery of disease-associated genetic variants and characterizing the biological impact of such variants using various in vitro and in vivo model systems.

    513-803-0975
    joseph.sherrill@cchmc.org

    Joseph D. Sherrill, PhD

    Academic Information

    Instructor, UC Department of Pediatrics

    Phone: 513-803-0975

    Email: joseph.sherrill@cchmc.org

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    Biography

    Dr. Sherrill first joined the Division of Allergy and Immunology as a research fellow in Dr. Marc Rothenberg’s lab where he began dissecting the genetic contribution of epithelial-derived genes to the pathogenesis of eosinophilic esophagitis (EoE). The central hypothesis of his studies is that single-nucleotide polymorphisms (SNP)s in epithelial-derived genes are contributory factors in the genetic and mechanistic development of EoE. His studies culminated in two first author publications in Nature Genetics and the Journal of Allergy and Clinical Immunology that identified EoE risk variants in the TSLP gene and its receptor. Dr. Sherrill is continuing to utilize his experience gained in modern genetic techniques (genome-wide association studies, exome sequencing, and RNA sequencing) and bioinformatics to investigate eosinophilic disease risk variants as the focus of his lab.

    Recognized as a promising junior faculty member, Dr. Sherrill has received a T32 training grant, the Thrasher Research Fund Early Career Award and is a recipient of the NIH Loan Repayment Program as well as numerous travel awards from the American Academy of Allergy, Asthma, and Immunology and the American Partnership for Eosinophilic Disorders. Dr. Sherrill also received the top place award at the 2011 Digestive Health Center poster symposium for his work on desmoglein-1 in eosinophilic esophagitis. 

    Education and Training

    PhD: University of Cincinnati, Cincinnati, OH, 2008.

    Research Fellowship: Division of Allergy and Immunology, Cincinnati Children’s, Cincinnati, OH, 2008-2012.

    Publications

    View PubMed Publications

    Grants

    Genetic dysregulation of desmoglein-1 enhances allergic sensitization in eosinophilic esophagitis. Principal Investigator. Thrasher Research Fund Early Career Award. 2012.
    A photo of Yui-Hsi Wang.

    Yui-Hsi Wang, PhD

    investigates the mechanisms that govern the plasticity of tissue resident TH2 memory / effector cells in the airway and gut. Particularly interested in understanding how inflammatory mediators, such as IL-1b, IL-33 and IL-25, regulate the development of IL-17-producing TH2 or IL-9-producing TH2 cells during airway or gastrointestinal allergic inflammation, respectively. 

    513-803-2193
    yui_hsi.wang@cchmc.org

    Yui-Hsi Wang, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-2193

    Fax: 513-636-3310

    Email: yui_hsi.wang@cchmc.org

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    Specialties

    Asthma; food allergy; T cell biology

    Education and Training

    PhD: University of Alabama, Birmingham, AL, 2001.

    Publications

    View PubMed Publications

    Grants

    The roles of IL-17-producing TH2 memory/effector cells in allergic asthma. Principal Investigator. American Lung Association. July 2010 - June 2012. #AI-169584-N.

    Regulation and maintenance of TH2 memory/effector cells. Principal Investigator. National Institutes of Health. May 2010- April 2015. #R01AI090129-01.

    A photo of Nives Zimmermann.

    Nives Zimmermann, MD Director of MS Track, Immunology Graduate Program

    focuses on deciphering mechanisms of allergic diseases, primarily asthma. Approaches include animal modeling and ex vivo cell and molecular biology. As eosinophils are the hallmark cell of allergic inflammation, including asthma, long-term goals include: 1) Understanding the mechanisms of eosinophilia and 2) Understanding the mechanisms of lung inflammation in homeostasis and allergic disease.
    Visit the Zimmermann Lab

    513-636-3887
    nives.zimmermann@cchmc.org

    Nives Zimmermann, MD

    Director of MS Track, Immunology Graduate Program

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-3887

    Fax: 513-636-3310

    Email: nives.zimmermann@cchmc.org

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    Specialties

    Asthma; allergy; eosinophils; lung inflammation

    Visit the Zimermann Lab.

    Education and Training

    MD: School of Medicine, University of Zagreb; Zagreb, Croatia, 1995.

    Publications

    View PubMed Publications