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Associate Director of Research, Cincinnati Children's Department of Anesthesiology Associate Professor, UC Department of AnesthesiologyAssociate Professor, Cincinnati Children's Department of Anesthesiology
Epilepsy CurrentsFrontiers in Neurology, Section on Epilepsy
2014 Research Achievement Award Cincinnati Children's Hospital Medical Center
In the rodent model of temporal lobe epilepsy, several distinct morphological changes in the dentate gyrus (DG) neurons of the hippocampus have been identified. It is believed that such changes contribute to the seizure activities associated with epilepsy. My interests are in characterizing and defining how these changes affect the excitability of the individual DG neurons and their connectivity to other neurons in the hippocampus.
Senior Research Assistant
Mary has 30+ years at Cincinnati Children's, but is a newer addition to the Danzer lab. She has research experience in tumor biology, gene regulation, immunology, GI development and vascular biology. Her current research focus is characterizing changes to the brain vasculature in both the chemical and genetic mouse models of epilepsy. She hopes to identify a potential role for vascular changes in seizure development. When she’s done fiddling with tubes and mice, Mary can be found at Women Writing for (a) Change where she is working on her first novel and completing a poetry chapbook.
Post-Doctoral Research Fellow
Candi received her PhD in Psychology from Texas A&M University, specializing in Behavioral and Cellular Neuroscience. She joined the Danzer lab in 2011 to research the anatomical and physiological abnormalities in the hippocampal network associated with Temporal Lobe Epilepsy. Her current research focus is determining the role of structurally abnormal granule cells in a hyperexcitable dentate network. When she is not in the lab, Candi can be found running, at the yoga studio, or at the theater enjoying an opera, ballet or a musical performance.
Post-doctoral NRSA recipient
Shadi received her PhD in 2013 from Colorado State University. Currently she is trying to address the question of how seizures progress using a genetic model of epilepsy. She is interested in the bioenergetics of epilepsy and how changes in metabolism may be a cause or a consequence of epileptogenesis. Outside the lab, Shadi likes to spend time in nature and enjoys hiking.
Shane received his PhD at the University of Colorado in 2015. His work there focused on mitochondrial function and oxidative stress in temporal lobe epilepsy. He is currently investigating the mTOR pathway and how it affects hippocampal granule cell integration in a mouse model of temporal lobe epilepsy. He is also examining the potential effects of cannabinoid signaling on the mTOR pathway as well as on epileptogenesis. When not in the lab, Shane is kept busy by a wonderful family with his wife and four very energetic kids.
Doctoral Graduate StudentUC Department of Neuroscience
Bethany's research involves studying the structural and functional changes observed in models of temporal lobe epilepsy. In particular, the involvement of newborn granule cells and the impact of the PTEN/mTOR/AKT pathway on neuronal circuits observed in epilepsy. Outside of the lab, Bethany creates beautiful wheel-thrown pottery. Her artwork can be found by visiting her website.
Doctoral Graduate StudentUC Department of Pharmacology
Salwa worked as a pharmacist for 4 years in Egypt before moving into research. Her initial work focused on in vitro anti-viral (HCV) and anti-cancer assays. She joined the Danzer lab in 2014 where her research has focused on how hyperexcitable, abnormal cells in the brain are connected to their neighbors and if this connection is altered in epilepsy. She is the president for GAPSS (Graduate Association of Pharmaceutical Science Students). When she is not in the lab, you can find her at the gym where she volunteers for Life Essentials Fitness and teaching Cincinnati Children's employees to get fit and strong.
Dr. Tong is visiting from Sheng Jing Hospital, China Medical University where she is an attending anesthesiologist. Dongyi was selected for a two year Pediatric Anesthesia Research Fellowship program sponsored by Cincinnati Children’s Hospital. She is investigating the role of mTOR in dentate granule cells as it pertains to epilepsy. In particular, she is focused on examining the role of one of the downstream effectors of mTOR called Raptor. Outside the lab, she enjoys traveling and making the most of her American experience.
MD/Doctoral Graduate StudentUC Medical Scientist Training Program, Department of Neuroscience
Aynara's primary research investigates the role of stress hormones in epilepsy and in the development of psychiatric comorbidities (depression and anxiety). She examines the contribution of glucocorticoid receptor signaling in the development of cortico-limbic circuit abnormalities and behavioral changes seen in animal models of temporal lobe epilepsy. In addition to her contributions to the lab, Aynara is an advocate for Latino health and co-founder of the Latino Medical Student Association chapter at UC. She is also a student representative for recruitment and admissions for UC’s Medical Scientist Training Program. Outside of the university, Aynara competes at local Crossfit competitions.
Pre-doctoral NRSA F-30 fellowship recipient (2015-2019)Yates Scholarship (2012-2015)Life Members Mentorship Grant, American Academy of Child and Adolescent Psychiatry (2015)Young Investigator Travel award, International Society of Psychoneuroendocrinology (2014)
Shatrunjai Singh received his Doctorate from Molecular Developmental Biology program at University of Cincinnati in 2015. He also received a Graduate certificate, Data Analysis from UC. After a fellowship at the Data Incubator in Washington, DC (2015), he took a position as a Data Scientist at John Hancock, Boston. His doctoral work and other interests can be found on his website.
Mike Hester received his Doctorate from Molecular Developmental Biology program at the University of Cincinnati in 2014. Mike is currently pursuing a Post-Doctoral fellowship at University of Pennsylvania.
Yifei Jiang (Visiting Research Scientist) is currently working as a clinical research coordinator at Cincinnati Children's.
Isaiah Rolle received his Doctorate from the Neuroscience program at the University of Cincinnati in 2015. Isaiah is currently pursuing DO at Ohio University.
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Steve Danzer, PhDAssociate ProfessorUC Department of Anesthesiology
Member, Division of AnesthesiaCincinnati Children's Hospital Medical Center
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