Danzer Lab

  • Current Projects

    Our lab explores the ways in which neuron development in the brain affects, and is affected by, epileptic seizures and autism. Through the study of late- and adult-generated neurons in the hippocampus, we hope to develop a better understanding of the fundamental mechanisms behind these diseases.  Understanding how the brain becomes epileptic or autistic will provide critical insights for developing new therapies to prevent and treat these diseases.

  • CONB calender.
    Hippocampus Cover 2004.
    Journal of Neuroscience 2002 cover.
    Neuroscience Cover.
    Society for Neuroscience brochure.
    Hippocampus 2008 cover.
    Neuroscientist Cover.
  • Show All

    Stress in epilepsy

    Stress in the development and progression of epilepsy

    Stress is widely recognized as a factor for provoking seizures in many patients with epilepsy. But despite clear evidence for a link between stress and seizures in humans, exactly how stress affects the occurrence of seizures in patients with epilepsy is not well understood. A better understanding of this process could lead to new strategies to control seizures. The goal of this project, therefore, is to explore the relationship between stress, stress hormones and seizures in animal models of epilepsy.

    2008-2010 − Charles L. Shor Foundation for Epilepsy Research. Cincinnati.
    SC Danzer, coprincipal investigator (in collaboration with James Herman, UC Department of Psychiatry).

    Impact of neonatal seizures

    Short- and long-term impact of neonatal seizures on hippocampal granule cell integration

    Seizures in children are common. The long-term consequences of these seizures, however, are still unclear. We examine the effect of neonatal seizures on the development of a brain region critical for learning, language development, cognition and imagination. These studies will help us determine how neonatal seizures may harm young brains and will guide the development of treatments to mitigate that damage.

    2009-2011 − National Institutes of Health, 1R03-NS-064378-01.
    SC Danzer, principal investigator

    Impact of PTEN deletion

    Selective disruption of hippocampal dentate granule cells in autism: impact of PTEN deletion

    This research intends to determine whether selective disruption of late-generated neurons – specifically hippocampal dentate granule cells – contributes to the development of autism. Although the proximal cause of autism is undetermined in most cases, the late generation of these neurons (in the late embryonic period and in infancy) may make them uniquely vulnerable to a variety of insults faced by the newborn child (e.g., infection). A connection between seizure-generated disruption in these cells and the development of autism could offer a path to mitigate or prevent autism. We will examine the role these neurons play by selectively eliminating genes implicated in autism in these cells in transgenic mice.

    2009-2014 − National Institutes of Health, 1R01-NS-065020-01.
    SC Danzer, principal investigator.

    Aberrant granule cell integration

    Contributions of aberrant granule cell integration to the development of epilepsy

    In adults, new brain cells are born daily in the hippocampus, a region that plays a role in common forms of epilepsy. Abnormal incorporation of these new cells into the brain may promote the development of the disease. We will investigate the role these new neurons play in the pathology, development and maintenance of epilepsy. By determining how normal brains become epileptic, we can begin to develop therapies to delay, halt and ultimately reverse the process.

    2009-2014 − National Institutes of Health, 1R01-NS-062806.
    SC Danzer, principal investigator.


 
  • Contact Us

    Steve Danzer, PhD
    Associate Professor

    Division of Anesthesia
    3333 Burnet Ave.
    MLC 2001
    Cincinnati, OH 45229

    Office Phone: 513-636-4526
    Lab Phone: 513-636-6235
    Fax: 513-636-7337
    Email: steve.danzer@cchmc.org