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Our lab is interested in the molecular mechanisms of sensory neuron plasticity after peripheral injuries. We have two main focuses: peripheral mechanisms of musculoskeletal pain specifically in the context of ischemia and the developmental sensitization of sensory afferents.
We know that ischemic myalgia is a major health issue that affects a large number of people and occurs in numerous disorders such as sickle cell anemia, peripheral vascular disease and even complex regional pain syndrome. A serious side effect of limb ischemia is peripheral muscle damage and as result of this damage, many patients with limb ischemia experience altered cardiovascular reflexes and musculoskeletal pain. Chronic pain in children however can arise from multiple sources including surgery, inflammatory disorders or even when in neonatal intensive care. While we do know a great deal of information about the role of nociceptors to the development of pain states, we do not have a comprehensive understanding of all subtypes of sensory fibers after ischemic muscle injury, during development or after neonatal injuries which may alter the function of sensory neurons into adulthood.
In order to increase our knowledge of these fibers, we utilize several ex vivo recording preparations that enable us to comprehensively phenotype cutaneous and muscle afferent fibers before and after peripheral injuries in neonatal and adult mice. In addition to electrophysiological recording, we also utilize a variety of other molecular (RNA interference, realtime RT-PCR, single cell PCR, single cell microarray, western blotting), anatomical (immunocytochemistry, fluorescence and confocal microscopy, electron microscopy), behavioral (mechanical and thermal hyperalgesia; spontaneous pain) and in vitro (primary neuron and heterologous cell cultures, second messenger signaling) techniques to obtain a broad understanding of pain development at the primary afferent level.
These studies will hopefully lead to the development of treatments for adverse changes in cardiovascular reflexes or chronic musculoskeletal pain associated with limb ischemia and will generate novel information on the development of both nociceptive and non-nociceptive afferents.
Our lab is also actively involved in the Neuromuscular Development Group. Our collaborations aim to accelerate research in the development and diseases of the neuromuscular system.
Jankowski M.P., Ross J.L., Weber J.D., Lee F.L., Shank A.T. and Hudgins R.C. Age-dependent sensitization of cutaneous nociceptors during developmental inflammation. Mol. Pain. 2014 Jun 7;10:34.
Ross J.L., Queme L.Q., Shank A.T., Hudgins R.C and Jankowski M.P. Sensitization of group III and IV muscle afferents after ischemia and reperfusion injury. J. Pain. 2014 Dec;15(12):1257-70.
Shabnam P., Xiaona L., Sameer K., Anderson J., Fumiyasu I., Wujuan S., Ciraolo G., Ratner N., Setchell K., Yoshida Y., Jankowski M.P. and Dasgupta B. The tumor suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature Comm. 2014 Sep 26;5:4993.
Jankowski, M.P.,Anderson, W., Anderson, C.E., and Koerber, H.R. Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration. J. Neurosci. 2012 Dec 5;32(49):17869-73.
Jankowski, M.P., Rau, K.K., Soneji, D.J., Anderson, C.E., Molliver, D.C., and Koerber, H.R. Purinergic receptor P2Y1 regulates polymodal C-fiber thermal sensitivity during peripheral inflammation. Pain. 2012 Feb;153(2):410-9.
Li, L., Rutlin, M., Abraira, V., Cassidy, C., Jankowski, M.P., Luo, W., Heintz, N., Koerber, H.R., Woodbury, C.J., and Ginty, D.D. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011 Dec 23;147(7):1615-27.
Molliver, D.C., Rau, K.K., McIlwrath, S.L., Jankowski, M.P., and Koerber, H.R. The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Mol. Pain. 2011 Feb 10;7:13.
Koerber, H.R., McIlwrath, S.L., Lawson, J.J.., Malin, S.A., Anderson, C.E., Jankowski, M.P., and Davis, B.M. Mouse cutaneous C-fibers lacking TRPV1 are sensitized to heat following peripheral inflammation. Molecular Pain. 2010 Sep 21;6:58.
Jankowski, M.P., Rau, K.K., Soneji, D.J., Anderson, C.E., and Koerber, H.R. Enhanced artemin/GFRa3 levels regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration. J. Neurosci. 2010 Dec 1;30(48):16272-83.
Rau, K.K., McIlwrath, S.L., Wang, H., Lawson, J.J., Jankowski, M.P., Zylka, M.J., Anderson, D.J., and Koerber, H.R. Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J. Neurosci. 2009 Jul 1;29(26):8612-9.
Jankowski, M.P., McIlwrath, S.L., Cornuet, P.K., Jing X, Salerno K.M., Koerber, H.R., and Albers, K.M. Sox11 transcription factor regulates peripheral nerve regeneration in the adult. Brain Res. 2009 Feb 23;1256:43-54.
Jankowski, M.P., Lawson, J.J., McIlwrath, S.L., Rau, K.K., Anderson, C.E., Albers, K. M., and Koerber, H.R. Sensitization of cutaneous nociceptors following nerve transection and regeneration: Possible role of target derived neurotrophic factor signaling. J. Neurosci. 2009 Feb 11;29(6):1636-47.
Jankowski, M.P. and Koerber, H.R. Neurotrophic Factors and Nociceptor Sensitization. In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton, FL: CRC Press; 2010.
Michael P. Jankowski, PhD Assistant ProfessorUC Department of Anesthesiology
Member, Division of Pain Management, Department of Anesthesia, & Department of Pediatrics, Cincinnati Children's Hospital Medical Center
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