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Our laboratory focuses on the mechanisms by which neurotransmitters are released and the impact of this on synaptic transmission. Synaptic transmission is the central event in interneuronal signaling, and as such, its study has direct relevance to all areas of human physiology, and is particularly relevant to anesthesiology because the synapse is the site of action of general anesthetics. Our research focuses on two areas: the biophysical mechanism of release of neurotransmitters from synaptic vesicles, and the specification of release site within the plasma membrane. We use a combination of molecular, microscopy and electrophysiological techniques to study this process.
Richards DA. Vesicle release mode shapes the postsynaptic response at hippocampal synapses. J Physiol. 587:5073-80. 2009.
McAuliffe JJ, Bronson SL, Hester MS, Murphy BL, Dahlquist-Topalá R, Richards DA, Danzer SC. Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy. Hippocampus. 2009.
Richards DA, Mateos JM, DePaola V, Caroni P, Gahwiler BH, Mckinney RA. Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures. Proc Natl. Acad Sci U S A. 102:6166-6171. 2005.
Richards DA, Bai J, Chapman ER. Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles. J Cell Biol. 168:929-939. 2005.
Bai J, Wang CT, Richards DA, Jackson MB, Chapman ER. Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions. Neuron. 41:929-942. 2004.
Richards DA, Guatimosim C, Rizzoli SO, Betz WJ. Synaptic vesicle pools at the frog neuromuscular junction. Neuron 39: 529-541. 2003.
Richards DA, Guatimosim C, Betz WJ. Two endocytic recycling routes selectively fill two vesicle pools in frog motor nerve terminals. Neuron. 27, 551-559. 2000.
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