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Our Asthma and Allergic Diseases Cooperative Research Center (AADCRC) is one of only 12 such centers in the United States. Gurjit Khurana Hershey, MD, PhD, is the principal investigator for this center, which received a renewal of its NIH-funded U19 grant this year.
The center’s overarching hypothesis is that epithelial cell genes play a central role in the pathogenesis of allergic disorders. Thus far, 10 peer-reviewed papers and five review articles and/or chapters have resulted from this grant.
Hershey, who also serves on the AADCRC steering committee, will continue to investigate the genetics of allergy-driven epithelial genes in children with asthma, atopic dermatitis and/or food allergy to identify shared and unique genes and pathways.
Cincinnati Children’s was selected this year to join the NIAID-funded Inner City Asthma Research Consortium (ICAC). The consortium, which includes 11 research centers, is the nation’s largest effort to study the factors that promote asthma in an inner city environment. Gurjit Khurana Hershey is the principal investigator for the Cincinnati Children’s subcontract.
The consortium’s objectives include conducting clinical studies to improve asthma control, prevent asthma among inner city children, and improve asthma phenotyping using validated biomarkers. The group plans to conduct longitudinal birth cohort studies as well as mechanistic studies involving human subjects to gain information on the early immunopathogenesis of asthma, to identify asthma risk factors for inner city children, and to study the differences in the early immunopathogenesis of asthma between inner city and non-inner city children.
