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The main interest of the Ji lab is to elucidate the
epigenetic basis of normal cellular development and chronic disease such as
asthma. Specifically we are interested to understand the epigenetic
mechanisms underlying heterogeneous asthma phenotypes and mediating the impact
of environmental exposures on disease risk.
Currently, we are focused on understanding the epigenetic
mechanisms underlying different treatment response of children hospitalized for
asthma. We are also investigating how diesel and other exposures modify
epigenome and asthma risk. The approaches we have taken include human
population studies and in vitro cell
models such as pluripotent stem cells and primary cells. The human population
study is a collaborative effort of multiple research groups including Dr.
Melinda Butsch Kovacic, Dr. Jocelyn Biagini
Myers, Dr. Gurjit Hershey and Dr. Patrick Ryan. In addition, we are focused on
understanding the epigenetic mechanisms that underline the differentiation and
function of dendritic cells in collaboration with Dr. Edith Janssen’s group.
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